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haysamrady

@sodatroubles

Nephrologist.

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03.12.2023
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Latest posts by haysamrady @sodatroubles

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Tubular Biomarkers Reveal Hidden Kidney Damage in Long COVID - Thailand Medical News

Tubular Biomarkers Reveal Hidden Kidney Damage in Long COVID

www.thailandmedical.news/news/tubular...

09.03.2026 02:16 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Membranous Nephropathy: Antigenic Landscape and a Novel Pathogenetic Model
#nephsky #nephrology
www.mdpi.com/1422-0067/27...

08.03.2026 14:13 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome Soluble CD93 contributes to podocyte injury, and CD93 blockade emerges as a candidate therapeutic target in INS.

Great paper from @carafuentes-neph.bsky.social !!
Tackling #nephroticsyndrome from many angles, better treatments are on the horizon!
Congrats Gabriel & team!!!!
#FSGS #pediatricnephrology #NephSky #SkyNeph #humangenetics
@science.org
www.science.org/doi/10.1126/...

07.03.2026 23:11 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Finally. The Hyponatremia Intervention Trial is published The Hyponatremia Interventional Trial (HIT) has been published in NEJM Evidence. The results were unveiled at the Late-Breaking and High-Impact Clinical Trials session at ASN Kidney Week 2024 in Sa…

Finally the Hyponatremia Intervention Trial is published and it is a big disappointment

pbfluids.com/2026/03/fina...

06.03.2026 12:55 πŸ‘ 22 πŸ” 9 πŸ’¬ 4 πŸ“Œ 1
graphical abstract

graphical abstract

Hypertension Rounds: Familial Hyperaldosteronism Type IV in a Mother-Daughter Pair

academic.oup.com/ajh/article/...

07.03.2026 15:15 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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GDMT for HFpEF and HFrEF
#Nephpearls #Cardiorenal #NephSky

πŸ‘‰πŸΌ www.acc.org/Education-an...

08.03.2026 03:29 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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State of the Art Review

Hypertensive Pregnancy Disorders: From Mechanisms to Management

academic.oup.com/ajh/article/...

06.03.2026 03:18 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Clinical course of proteinuria due to cubilin variants: a large multicenter pediatric cohort - Pediatric Nephrology Introduction We aimed to evaluate the clinical and genetic characteristics and clinical course of children with persistent proteinuria associated with CUBN variants. Methods Forty-eight children with ...

Clinical course of proteinuria due to cubilin variants: a large multicenter pediatric cohort
@ped-neph.bsky.social
link.springer.com/article/10.1...

06.03.2026 20:34 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
The conflict in Iran is disrupting fertiliser production and exports in the Middle East, tightening global supplies and raising fears of higher food prices, industry executives and analysts have warned.

The Middle East is one of the world’s largest fertiliser producers, while the Strait of Hormuz is a crucial shipping route for exports. About 35 per cent of global urea exports pass through the waterway, according to CRU data. Urea is the most widely used nitrogen fertiliser, which in turn underpins around half of global food production.

The route also handles 45 per cent of global sulphur exports, a key ingredient used to produce phosphate fertilisers, as well as significant volumes of ammonia, a key ingredient for nitrogen fertilisers.

β€œWe shouldn’t underestimate what this potentially could mean for global food production,” said Svein Tore Holsether, chief executive of Europe’s largest fertiliser group Yara.

He added that the focus on oil and gas was β€œovershadowing” the impact on the fertiliser industry. β€œIf you’re not getting [fertiliser] into the field of the farmers, yields could go down by up to 50 per cent in the first harvest,” he said.

If the disruption continues, consumers could see higher prices for bread within six to 10 weeks, eggs within a few months and pork and broiler chicken within six months, estimates Raj Patel, food system expert at the Lyndon B. Johnson School of Public Affairs. 

Fertiliser prices have already jumped sharply. Granular urea prices in the Middle East have risen by about $130 to around $575-650 a tonne since Friday, while Egyptian export prices have climbed by around $125 to around $610-625 a tonne over the same period, according to Argus.

European ammonia futures have also surged, with a 1,000 tonne April cargo trading at $725 a tonne β€” about $130 higher than when the contract last traded in mid-February.

The conflict in Iran is disrupting fertiliser production and exports in the Middle East, tightening global supplies and raising fears of higher food prices, industry executives and analysts have warned. The Middle East is one of the world’s largest fertiliser producers, while the Strait of Hormuz is a crucial shipping route for exports. About 35 per cent of global urea exports pass through the waterway, according to CRU data. Urea is the most widely used nitrogen fertiliser, which in turn underpins around half of global food production. The route also handles 45 per cent of global sulphur exports, a key ingredient used to produce phosphate fertilisers, as well as significant volumes of ammonia, a key ingredient for nitrogen fertilisers. β€œWe shouldn’t underestimate what this potentially could mean for global food production,” said Svein Tore Holsether, chief executive of Europe’s largest fertiliser group Yara. He added that the focus on oil and gas was β€œovershadowing” the impact on the fertiliser industry. β€œIf you’re not getting [fertiliser] into the field of the farmers, yields could go down by up to 50 per cent in the first harvest,” he said. If the disruption continues, consumers could see higher prices for bread within six to 10 weeks, eggs within a few months and pork and broiler chicken within six months, estimates Raj Patel, food system expert at the Lyndon B. Johnson School of Public Affairs. Fertiliser prices have already jumped sharply. Granular urea prices in the Middle East have risen by about $130 to around $575-650 a tonne since Friday, while Egyptian export prices have climbed by around $125 to around $610-625 a tonne over the same period, according to Argus. European ammonia futures have also surged, with a 1,000 tonne April cargo trading at $725 a tonne β€” about $130 higher than when the contract last traded in mid-February.

Urea in fertilizers comes from natural gas?

www.ft.com/content/7efe... Fertiliser disruption from Iran conflict prompts global food shortage warnings

(Gated link - but see alt text for the details)

05.03.2026 11:37 πŸ‘ 4 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
Tubular Stress Markers and Future Risk of Sepsis-Associated Acute Kidney Injury Sepsis is a leading cause of death, especially when complicated by acute kidney injury (AKI), a common clinical syndrome linked to chronic kidney disease (CKD) progression1, cardiovascular disease (CV...

Tubular Stress Markers and Future Risk of Sepsis-Associated Acute Kidney Injury
#nephsky #nephrology
www.kidneymedicinejournal.org/article/S259...

05.03.2026 14:03 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Figure 1 Ten steps to achieve comprehensive medication management. Adapted from the Get the Medications Right Institute15 with permission of the copyright holder (Get the Medications Right Institute). Abbreviations: CMM, comprehensive medication management; OTC, over-the-counter.

Figure 1 Ten steps to achieve comprehensive medication management. Adapted from the Get the Medications Right Institute15 with permission of the copyright holder (Get the Medications Right Institute). Abbreviations: CMM, comprehensive medication management; OTC, over-the-counter.

Optimizing Comprehensive Medication Management in CKD: An Opportunity to Integrate Pharmacists in the Kidney Care Team

bit.ly/4u8FK1g

04.03.2026 11:00 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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πŸ†• in Nature Reviews Nephrology: our Review on social determinants of health & #AKI.

A πŸ”‘ message: improving AKI outcomes requires more than better clinical careβ€”it also requires confronting social, structural and environmental inequities.

πŸ”— 10.1038/s41581-026-01063-3

#AKI #Nephrology #KidneyHealth

05.03.2026 03:28 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
figure of albuminuria reduction with finerenone

figure of albuminuria reduction with finerenone

Finally, FINEONE shows Finerenone
reduces albuminuria in T1DM

www.nejm.org/doi/full/10....

@nejm.org #NephSKy

05.03.2026 00:02 πŸ‘ 30 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0
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Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Age is just a number, kidney transplant edition

An 87 year old transplant recipient

journals.sagepub.com/doi/10.1177/...

04.03.2026 23:28 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Dialysis delay at what cost? Protein restriction as a distraction in the age of GDMT β€” NephJC The NephJC shorts on cost-efficiency of low-protein diets and ketoanalogues as a distraction from CKD-relevant therapies in the 21st century… wait, only if the comparator wouldn’t be dialysis.

Can an ineffective intervention be cost-effective?

Cristina Popa breaks down the latest low protein diet proponents insipid attempt for a #NephJC Shorts

www.nephjc.com/news/2026/2/...

05.03.2026 02:02 πŸ‘ 13 πŸ” 5 πŸ’¬ 4 πŸ“Œ 0

Saw in an ICU resident note today. "Anuric for one week, on AVVH at night but renal function is improving. eGFR and creatinine better". You could mock it but this is happening because we continue to report eGFRs in patients for whom it is completely inappropriate. #nephsky

05.03.2026 01:16 πŸ‘ 7 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
While the volume of out-of-sequence transplants has increased rapidly, this has been particularly stark for unilateral out-of-sequence transplants. The rapid increase in this practice is hard to understand and counters the argument that out-of-sequence placements are necessarily due to organ quality concerns, given that a kidney from the same donor was successfully placed. Additionally, the rapid decrease in the sequence at which OPOs start out-of-sequence allocation, of kidneys across the KDPI spectrum, suggests an increasing level of comfort by the OPO community to use this pathway for organ placement despite the potential adverse consequences for patients who are skipped.8,15-19 Our results indicate that the increasing use of the out-of-sequence pathway is associated with inequalities in transplant outcomes and care, with recipients of unilateral out-of-sequence transplants having disproportionately higher rates of educational attainment, private insurance, and preemptive transplant than recipients of their unilateral in-sequence counterparts.7,11 Our results also suggest that there are inequalities among recipients of unilateral out-of-sequence transplants that are performed at the same center as its mate kidney, compared with recipients of unilateral out-of-sequence transplants performed at different centers, although the underlying reasons are still unclear.

While the volume of out-of-sequence transplants has increased rapidly, this has been particularly stark for unilateral out-of-sequence transplants. The rapid increase in this practice is hard to understand and counters the argument that out-of-sequence placements are necessarily due to organ quality concerns, given that a kidney from the same donor was successfully placed. Additionally, the rapid decrease in the sequence at which OPOs start out-of-sequence allocation, of kidneys across the KDPI spectrum, suggests an increasing level of comfort by the OPO community to use this pathway for organ placement despite the potential adverse consequences for patients who are skipped.8,15-19 Our results indicate that the increasing use of the out-of-sequence pathway is associated with inequalities in transplant outcomes and care, with recipients of unilateral out-of-sequence transplants having disproportionately higher rates of educational attainment, private insurance, and preemptive transplant than recipients of their unilateral in-sequence counterparts.7,11 Our results also suggest that there are inequalities among recipients of unilateral out-of-sequence transplants that are performed at the same center as its mate kidney, compared with recipients of unilateral out-of-sequence transplants performed at different centers, although the underlying reasons are still unclear.

The increasing numbers of β€˜out of sequence’ kidneys being allocated by certain OPOs

This is a scandal of unaccountable behaviour - and certain patients are benefiting while others are losing out of coming off dialysis

jamanetwork.com/journals/jam... from Sumit Mohan and colleagues in JNO

05.03.2026 02:25 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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SGLT2-inhibitors in adult patients with Alport Syndrome Alport syndrome (AS) is a genetically heterogenous kidney disease characterised by microhaematuria, proteinuria, and progressive chronic kidney disease (CKD). Although early renin-angiotensin system i...

SGLT2 inhibitors in adult patients with Alport Syndrome
#nephsky #nephrology
www.kireports.org/article/S246...

05.03.2026 04:23 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
Figure 1 Flowchart integrating ADA 2025 screening recommendations, ATP III criteria, and OGTT-based risk stratification for future diabetes risk among living kidney donor candidates.

Figure 1 Flowchart integrating ADA 2025 screening recommendations, ATP III criteria, and OGTT-based risk stratification for future diabetes risk among living kidney donor candidates.

Online & in press! "Personal Viewpoint: Risk stratification and counseling of living kidney donor candidates with prediabetes," by Achkar et al
www.amjtransplant.org/article/S160...
@katafanachkar.bsky.social

03.03.2026 13:15 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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#NephMadness 2026: Animal House Region Submit your picks! |Β @NephMadness | @nephmadness.bsky.social |Β NephMadness 2026 Selection Committee Member: Autumn HarrisΒ  At NC State University, Dr. Autumn Harris investigates how kidneys regulat…

#NephMadness 2026: Animal House Region

Teams: Dogs vs Cats

Experts: Autumn Harris & Kelly Hyndman
Writers: Sarah Street & Susan DiGiovanni
Execs: @kidneywars.bsky.social & @nephrosparks.bsky.social rks.bsky.social

bit.ly/NM26Animals

03.03.2026 14:55 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Image Quiz! A patient underwent renal transplantation 3 weeks earlier, subsequently developed oliguria, and was found to have circulating donor specific antibodies. Kidney biopsy was performed, and immunofluorescence for C4d is shown. What does the image demonstrate?

(Continued in thread)

03.03.2026 18:27 πŸ‘ 3 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Use of auto BP devices is rec'd by guidelines but many still measure BP manually. In this preprint, we categorize BP device based on terminal digit (manual BP results in even # terminal digits). Manual BP ~6mmHg lower and associated with 1.16x stroke risk vs automated www.medrxiv.org/content/10.6...

02.03.2026 20:01 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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A medical journal says the case reports it has published for 25 years are, in fact, fiction A Canadian journal has issued corrections on 138 case reports it published over the last 25 years to add a disclaimer: The cases described are fictional. Paediatrics & Child Health, the journal…

This story is nuts

The journal β€˜Pediatrics and Child health’ has been published an article type, for case reports, that are made up and fictional without having any clear notice 😱

retractionwatch.com/2026/03/03/c...

04.03.2026 02:06 πŸ‘ 245 πŸ” 105 πŸ’¬ 9 πŸ“Œ 38
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In a 23yo M with proteinuria, hematuria and CKD, what is your diagnosis?

#DiagnoseThis #nephsky #pathsky #renal #kidneypath

02.03.2026 14:03 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Bone marrow-derived inflammatory signals may shape glomerular disease in ways that we are only beginning to understand. Read this article in #ASNKidneyNews following one of the most prominent and debated candidates, suPAR: kidney.pub/KN1802-15

02.03.2026 15:00 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Do you check labs after starting SGLT2i in CKD patients?

What % of pts drop eGFR >30% after starting SGLT2i?

What are the usual causes if that happens?

Do you know of any studies that specifically looked at that?

@askrenal.bsky.social #flozinators

01.03.2026 11:56 πŸ‘ 2 πŸ” 2 πŸ’¬ 5 πŸ“Œ 0
NephMadness brackets

NephMadness brackets

Some of these are easy (Targeted B cell >>> complement in IgA) so unless #BRPFail we should be OK

Many others are hard

And

πŸ• 🐢 versus 🐈 🐱 πŸˆβ€β¬›??

That’s madness. True #NephMadness 🫑

01.03.2026 12:14 πŸ‘ 12 πŸ” 3 πŸ’¬ 5 πŸ“Œ 0
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Autosomal dominant polycystic kidney disease Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease, resulting in substantial morbidity and mortality globally. Advances in molecular geneti...

Autosomal dominant polycystic kidney disease - The Lancet - goo.gl/alerts/z9EVkq #GoogleAlerts

28.02.2026 04:36 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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β˜‘οΈ

28.02.2026 06:07 πŸ‘ 17 πŸ” 2 πŸ’¬ 4 πŸ“Œ 0
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Hypophosphatemia During Kidney Replacement Therapy and Ventilator-Free Days: A Post-Hoc Analysis of the STARRT-AKI Trial Critically ill patients receiving kidney replacement therapy (KRT), especially continuous KRT (CKRT), have a high risk of hypophosphatemia due to extracorporeal losses, which may contribute to muscle ...

I would love to see an RCT of Phox vs no Phox or even a redo of the high intensity trials using a Phos-containing fluid. There is just so much evidence that zero-phos fluids are bad for you. Also, please someone give us a Phox with dextrose. #medsky #nephsky

28.02.2026 16:15 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1