As a someone with a 33 year NIH-funded lab whose grant is supposed to be reviewed this week, shut NIH down if that is what's needed to end ICE terrorism. Innocent lives are more important 🧪
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Figure showing that Y822 phosphorylation regulates VCL recruitment to cell-cell contacts in cultured CMs.
Xiaofei Li, Adam Kwiatkowski @kwiatkowskilab.bsky.social, Glenn Radice and colleagues discover that vinculin Y822 phosphorylation regulates adhesion remodelling during cardiomyocyte maturation.
journals.biologists.com/jcs/article/...
A key role for Canoe's intrinsically disordered region in linking cell junctions to the #cytoskeleton. New study from Corbin Jensen, Mark Peifer (@peiferlabunc.bsky.social) and colleagues @unclineberger.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion #Drosophila
🎥 New video summary of a recent paper by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social (rupress.org/jcb/article/...), revealing cellular mechanisms of tissue fusion in the developing face.
Calling all postdocs! Applications are open for Dept. of Molecular Biosciences 3rd Trailblazers Postdoctoral Symposium @utaustin.bsky.social. Come to Austin, meet your peers, showcase your work. Application is easy and all expenses are paid! Spread the word!
tinyurl.com/yw7ffjn9
From MBoC... Ronald Wek and colleagues show PERK helps skin cells migrate during healing—not by its kinase activity, but by acting as a structural supporter for key adhesion proteins.
A fresh look at how keratinocytes stay connected and move together.
🔗 www.molbiolcell.org/doi/10.1091/...
To my fellow old farts: amplify junior PIs debuts. All of ‘em 🙌🏻👏🏻 all the best Maik, go get it.
Congrats to one of the most talented folks with whom I have ever worked. Follow Maik as he pursues new insights into morphogenesis using highly innovative multi-disciplinary tools! 🧪
So, let me share the NIGMS processes from my time.
1/8
New septin paper by our next door lab neighbors @ebrahim-lab.bsky.social, and on the cover of JCI Insight no less.
Septin 9 reinforces intestinal epithelial junctions, preventing leaky gut and inflammation.
Check it out!
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
It was a great pleasure attending my first #HUPO world congress in Toronto last week and sharing our catenin phospho-code story! It was inspiring meeting with peers and pioneers in the field, which reminded me how special the proteomics community is!
A new enzyme-free technique uses alternating electrochemical currents to gently detach cells from culture surfaces, maintaining high cell viability and reducing waste in biomanufacturing processes. doi.org/hbbs27
Thank you UVa for being the first places asking for grad school recomendations that did not include ANY of the silly ratings questions
Bluesky folks, @jfhorner.bsky.social is also ON THE JOB MARKET! Check out his work 🧐... he's SUPER TALENTED and a pleasure to work with!
Full text in links
Full text in links
Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
that time of the year... writing letters for 8 UG's applying to grad school, each of them to ~15 programs. And while I passionately support every one of them, thats A LOT of letters, a lot of web sites to keep track of, a lot of my time. Why dont Grad programs use interfolio? One and done???
Text of a statement from Dr. Dixon
After a "suspension" of just a few days, UNC Professor Dwayne Dixon is re-instated, revealing the weakness of the fabricated issues used for the suspension. Here is his response. Stand up to the fascists--when we work together we can triumph.
My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls
Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨
🔗 www.nikonsmallworld.com/galleries/20...
#NikonSmallWorld #Microscopy #ScienceArt
Kate's work is remarkable--saw it at the Cell Contact and Adhesion GRC. Hiring faculty--she's a scientist to watch
Dear Director Bhattacharya: I listened to more of your conversation with Glenn Beck. You made a number of statements that are false and misleading. You have considerable responsibilities in your current position and need to live up to them. You dismiss critics of President Trump's comments at the press conference by saying: "I think the key point here is something called "Trump Derangement Syndrome".
A new email to Director Bhattacharya this morning.
1/n
"Head down focus on the science" folks: here is one super easy thing you can do today.
Dear Director Bhattacharya: I attended the NIAID Council meeting online. I wanted to raise two points. First, I was disappointed that you sent a video of your presentation rather than showing up in person or, at least, attending live but virtually. You are missing out on important opportunities to interact with NIH staff and Advisory Council members. These individuals use their expertise and considerable time and energy to try to further the NIH mission. In addition, you are sending a signal about your priorities. This is especially true when you spend your time by appearing on The Glenn Show within a day. I realize that it was important to try to clean up the mess made primarily by President Trump at your press conference when he said repeatedly "Don't Take Tylenol!".
An email to Director Bhattacharya to start the day
1/6
Super cool work from our institute!
Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...
Top-Down Individual Ion Mass Spectrometry Reveals 85-110 kDa Catenin Phospho-Proteoforms Regulated by Actomyosin Contractility https://www.biorxiv.org/content/10.1101/2025.09.06.674621v1
I'm more than a little excited about this interstellar visitor 🧪
The images keep getting better and the insights deeper
PS this is just some of the science funded by the NSF that is threatened by devastating budget cuts--speak up and call Congress.
www.sci.news/astronomy/in...
We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
