JJ Perez Moreno

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration - Nature Neuroscience Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

I am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...

Fascinating. Why it may be good to be conceived in the winter.
More brown fat (which is really good) as an adult.
@naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...

SciArt profile: Maria Diaz de la Loza - the Node In our latest profile, we feature Maria Diaz de la Loza, a freelance illustrator and researcher in the Stramer lab at King's College London

More about me and my work in @the_Node SciArt profiles!
thenode.biologists.com/sciart-profi...

Hoy se publica ‘Las Arquitectas de la Vida’ (Paidos) versión en castellano de “The Master Builder’. Un argumento en favor de una visión de la naturaleza desde la perspectiva de la celula altruista en contraste con la prevalente centrada en el gen egoista.

Rhodoquinone carries electrons in the mammalian electron transport chain Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal el…

Congratulations to Jessica Spienelli and her lab for the groundbreaking work.

www.sciencedirect.com/science/arti...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
www.nature.com/articles/s41...

School of Biological Sciences strengthens commitment to Four new academic positions have been launched in the School of Biological Sciences aiming to recruit outstanding scientists in areas of significant research importance: Associate Professor /

Come and join us! Four (yes 4) new positions as Associate Prof or Professor in @cambridgebiosci.bsky.social‬ in:
-Evolutionary Genomics
-Developmental Plasticity & Robustness
-Infection and/or Immunity
-Molecular & Cellular Biology
Not involved in recruitment (AFAIK), but happy to discuss.

🚨Version of Record of our ppaer 📜is out In @eLife: Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum doi.org/10.7554/eLif...

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports imageimageA reduction in oxidation phosphorylation is considered to be a hallmark of pro-inflammatory macrophage polarization. This study shows that respiratory inhibition is not required for macropha...

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports

www.embopress.org/doi/full/10....

Foto del libro sobre una vitrina de caracolas. Foto realizada por Marisa Castiñeira. Como nota informativa, el sorteo lo haré con los RT que haya el domingo 22 de diciembre. Los dos libros solo se enviarán a laguna dirección en España. Estos dos libros son diferentes a los que estoy sorteando en la "otra red social"... Así que igual puedes conseguir dos...

Llegamos a la época de los regalos y yo me he propuesto a difundir un poco más la ciencia.

Voy a sortear dos ejemplares de «Papá, ¿cómo se enroscan las caracolas?» entre las personas que reposteen este mensaje. Así la #GeomNatura llegará a más gente. Más info en la descripción.

Scanning electron microscope image of a human trunk-like structure (left) and human embryo (right) false coloured for somites (magenta) and neural tube (gold).

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

May commissural axons find their way in here 🙏
#Microscopy #LiveImaging #AxonGuidance #Neuroscience

2024 no puede acabar sin esto...✨nuestro TOP de lo más visto en Filmin✨

"Anatomía de una caída" lidera el top de las películas que más habéis visto.

Illustration with The Kelvin structure, The Wearie-Phelan structure and the scutoids.

And now in english... We are very happy! In this interesting article of SCIENTIFIC AMERICAN, the #scutoids reach the status of a reference shape to tile the 3D space; being compared with the Kelvin structure. #SciComm

www.scientificamerican.com/article/math... by @elisecutts.bsky.social

3D reconstruction of the surface of a microglia cell from mouse brain.

Glad to share in this new platform our latest work (Alberto Pascual lab), where we study the role of the electron transport chain in microglia during development.
www.nature.com/articles/s42...

@natureportfolio.bsky.social

Full text: rdcu.be/dONoN

“Behind the paper” post: go.nature.com/3KKdjBv

Espectacular, Patri! Bravo! 👏

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution.
www.nature.com/articles/d41...

Fantastic source for many of us! Thanks, Fernando

Electron microscopy image of a mouse microglia marked with Iba1

I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology.

doi.org/10.1098/rsob...

I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM

#microglia #electronmicroscopy
#tremblaylab

Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters - Nature Communications Studying membrane contact sites at high spatiotemporal resolution is still challenging. Here, authors introduce a series of dynamic chemogenetic reporters to visualize these subcellular regions and st...

detection of membrane contact dynamics and Ca2+ signals
w/ nice acronym-

PRINCESS (PRobe for INterorganelle Ca2+-Exchange Sites based on SplitFAST), a class of reporters to simultaneously detect MCSs and measure the associated Ca2+ dynamics using a single biosensor

www.nature.com/articles/s41...

Review title

Review sections graphic

Sub compartments of mitochondria graphic

Mitochondrial.dynamics graphic

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

www.annualreviews.org/content/jour...

#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

Congrats, Rafa!!! Great news

Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋

go.bsky.app/DT3Cp4A

Thanks, Nicola! I would like to join, please

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems Lloyd et al. generated a comprehensive microglia proteome database, identifying over 11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated with protein synthesis, ...

My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...

NaukasVA 2024_03_Luisma Escudero YouTube video by Parque Científico de la Universidad de Valladolid

En primicia, para todo cielito azul!!
Mi charla en #NaukasValladolid sobre la ciencia del futuro... basándose en el pasado... Embriones, experimentos de trasplantes y cómo luchar contra el cáncer...

Por supuesto hay su ración de #escutoides.

www.youtube.com/watch?v=mzU7...