Aura Carreira

PARP inhibitor synthetic lethality reveals homologous recombination sub-pathway architecture https://www.biorxiv.org/content/10.64898/2026.03.06.709881v1

🌱 New preprint out on bioRxiv!

How do plants sense seasonal changes in day length?

In our new study, we profiled high resolution (2h) RNA seq time courses in tomato across three photoperiods to uncover how light duration shapes gene expression dynamics.

Summary in next post...

We are celebrating our research institute @cabimer.bsky.social 20th anniversary!! Superb list of speakers!! And attendees!!

Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...

🎓 Registrations are open for the next Post-transcriptional Gene Regulation international course at @institutcurie.bsky.social with international experts, until march 31st 2026.

📆 18-22 may
📍 Institut Curie, Paris
🗒️ More infos on training.institut-curie.org/courses/post...

It was a great pleasure to host @fmattiroli.bsky.social in her visit to the @cbm-csic-uam.bsky.social
Wonderful science and discussions!

We are looking for Postdoctoral Fellows with expertise in Structural Biology. Expertise in CryoEM/CryoET is required. Come join us in St. Louis to work on some amazing enzyme complexes.
www.antonylab.org/positions.html

APPLY HERE: slu.wd5.myworkdayjobs.com/en-US/Career...

Dozens of researchers will move to France from US following high-profile bid to lure talent Nature - Large proportion worked at Columbia University, which had its grants cut and frozen by the administration of US President Donald Trump.

Almost all of the scientists were previously at US institutions

go.nature.com/4tzxGX5

A beautifully crafted summary of the extraordinary discovery in the lab of my @mrclmb.bsky.social colleague @philholliger.bsky.social of a tiny RNA that can replicate RNA.

Y hoy, #11F, las mujeres científicas del #CBM llenan el Auditorio.
¡Y no caben todas!
Como referencia, el 4️⃣0️⃣% de los/las IPs del CBM son mujeres.
@csic.es @uam.es @cbm-csic-uam.bsky.social

Celebramos el #11F con una foto de nuestras compañeras científicas, técnicas, gestoras, etc., en el CBM. 👩‍🔬💫 ¡Por más visibilidad, igualdad y oportunidades para las mujeres en ciencia!
#MujeresYCiencia #diadelamujerylaninaenlaciencia #TodasHacemosCiencia

Events for February 2026 06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

We go live!!!

Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field

AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social

@replifate.bsky.social @epicrossborders.bsky.social

replifate.eu/event/meetin...

Con motivo del #11F abrimos nuestras puertas a las jóvenes científicas 👩‍🔬
Taller práctico en el CBM con alumnas de ESO en colaboración con STEMTalentGirl, guiado por Celia García y Eva Richard.
Acercar la ciencia a las chicas es clave para construir el futuro.

@csic.es @uam.es

How Aging clock reveals molecules that protect against neurodegeneration healthmedicinet.com/aging-clock-...

Pre-incision structures reveal principles of DNA nucleotide excision repair - Nature Cryo-electron microscopy structures of nucleotide excision repair complexes reveal the roles of the constituent proteins XPA, XPB, XPC, XPD, XPF, XPG and RPA in DNA bubble formation and excision ...

Our great collaboration with the lab of Wei Yang and Kaoru Sugasawa is now online in Nature. We’re glad we could contribute some cell biology to complement this beautiful structural and biochemical work.

www.nature.com/articles/s41...

A group of about 30 people pose together in a bright office space.

Today, we’re launching a new company, ALTx Therapeutics. Founded by Simon Boulton, the company will develop the first precision therapies targeting ALT cancers, in partnership with Slingshot Therapeutics Limited and @crhorizons.bsky.social.

Find out more ➡️ www.crick.ac.uk/news/2026-02...

Today is World Cancer Day, but do you know the signs and symptoms of breast cancer?

Get to know your normal by checking your breasts regularly.

Touch your breasts✋

Look for changes👀

Check anything new or unusual with a GP✅

breastcancernow.org/about-breast...

Prevent 2026 PREVENT 2026

Este otoño llega a Madrid #PREVENT2026, workshop sobre predisposición genética y prevención de la leucemia infantil, coorganizado por nuestro investigador César Cobaleda.
📍CSIC – Serrano 117
🗓️25 de septiembre
Info y registro 👉 prevent2026.org

🚀 Postdoc opportunity!
Our lab is looking for a candidate to work on tumor drivers in BRCA2‑mutated cancer.
If you're interested in applying, feel free to email me or send a DM! DEADLINE March 30th eacr.org/eacr-fellows...

Please note that the zoom link for tomorrow's webinar with @nitikataneja.bsky.social and @doksanilab.bsky.social has been updated:
uzh.zoom.us/j/6466274666...

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

Our Science paper is out! 😃

www.science.org/doi/10.1126/...

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

📚📢 Ha salido el nuevo Catálogo de Conferencias Científicas del @csic.es para centros educativos y entidades en Madrid. El CBM ofrece 17 charlas divulgativas sobre biología, cáncer, inmunología, virología, biotecnología y más. ¡Solicita la tuya! 👩‍🔬👨‍🔬
🔗 delegacion.madrid.csic.es/catalogo-con...

A study in @science.org from Paul Cohen's lab, led by @maschakoenen.bsky.social, demonstrates how beige fat directly influences blood pressure. The findings offer a new target for treating vascular disease and could lead to more precise therapies for hypertension: https://bit.ly/4pK0hGh

I'm beyond excited and thrilled to share that my first (co)-first-author research paper has been published in Nature 🎉
If I say Transcription-Replication Conflict, do cilia proteins pop in your head? No? Well, understandable, but you'd be wrong! Intrigued? Then read this paper!

Excited to share our new Nature study! 🧬

We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.

Full paper: www.nature.com/articles/s41...

A picture of current members of the Groth lab

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social

Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Transcription stress causes an inflammatory response via release of IL-1α Nature Structural & Molecular Biology, Published online: 11 April 2025; doi:10.1038/s41594-025-01525-5DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.

New online: Transcription stress causes an inflammatory response via release of IL-1α