Finally out in @natmicrobiol.nature.com: Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Great work by @stephkoe.bsky.social @kassipan.bsky.social @jvhooff.bsky.social
www.nature.com/articles/s41...
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
Never to early to teach your little one about adaptive immunity 👼
Any day is a good day to abolish ICE
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
So cool - someone finally hacked 'the vault'.
www.science.org/doi/10.1126/...
What a wild and beautiful structure, congrats to the authors!
Same! Miss the hay day of science Twitter so much 😩
Seen elsewhere… and was triggered. Don’t think I would set up the void peak that has the lower melting temperature if I only had one chance. The small monomer and higher melting curve in the dotted example however.. don’t trust your AI infographics
Update being a dad there’s this little guy walking around my house and I love him so much it’s awesome
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Slide describing sisyphus, socrates, and hercules as symbols for my postdoc progress, background slides, and my PhD work, respectively.
Just found this slide from a group meeting presentation I gave to my postdoc lab in the height of pre-vaccine COVID lol I was going through it
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
To test how few images we could get away with, I took progressively smaller subsamples of the Aca2-RNA blob-picked stack and repeated HR-HAIR with the same random seed.
Using a 60k stack (<10% of the total), high res features are still easily discernible in the good class (~20k ptcls)
if you're not from or have never been to new york i cannot stress enough how normal the subway is 99% of the time. kids take it to school. everyone is basically chill. you learn to be in proximity with harmless weirdos or minor irritations pretty quick. for all its issues it's an incredible thing
Choose your fighter
Losing my grant doesn’t make me worried that having it on my resume will hurt my career. Rather, I worry about what it means for science, I worry about it means for the active work I do and will KEEP doing to uplift, I worry about what it means for upcoming and future scientists.
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
Completely agreed!
This has been so frustrating and disappointing to see. If anyone has tremendous influence it’s pharma leaders, all of whom have NIH-funded research to thank for their success. I think it’s fear of retaliation that’s keeping them quiet
Join us at Amgen Structural Biology in SoCal! Work on #xray and #cryoEM.
careers.amgen.com/en/job/thous...
Great advice on transitioning from academia to industry. I would add that you should also be prepared to discuss why you applied to a specific company. Find details in their platform or targets to discuss. Interview teams see you as a flight liability if you’re just looking for any industry position
Thanks and totally agreed!
And finally, talk to as many people in your network that work in industry as possible. My experience and advice are not universal, and it's best to get as many viewpoints as possible before making such a big decision (7/7)
For the seminar: try not to present your work as a neatly packaged, fully-formed story. The team want to see how you thinka nd what you did in addition to what you learned. Go into some details of the problems that arose during the investigation and your troubleshooting process to solve them (6/7)
During interviews, make sure you have a good narrative as to why you're making the switch - simply saying you don't think things are looking good in the academic sector won't cut it. You have to make a case that you actually WANT to work in pharma/biotech (5/7)
