Joris van de Haar, MD, PhD

@forum-gd.bsky.social

#spatial #postdoc #cancer #cancerimmunology #immunology

@nkinl.bsky.social @oncodeinstitute.bsky.social

Postdoc alert in spatial biology!

Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology.

Learn more / apply here: www.nki.nl/careers-stud...

@nkinl.bsky.social @oncodeinstitute.bsky.social

@riklindeboom.bsky.social

Learn more & apply: www.werkenbijavl.nl/vacatures/po...

🚀 We’re hiring!
Join our team at the NKI as a Postdoc, using Quantitative Membrane Proteomics to design novel cancer immunotherapies!
Best of two worlds from the Voest and Lindeboom Labs.

Cutting-edge proteomics, translational immunotherapy and world-class instrumentation? let’s connect! 🔬💡

🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu

Very cool study! A very logical explanation for the fundamental question how non-stem cells “know” they need to become one after tissue damage. And is this deregulated in cancer?

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Important work towards one of the holy grails in cancer immunotherapy: understanding/predicting/designing TCR specificities

ESMO Precision Oncology Working Group recommendations on the structure and quality indicators for molecular tumour boards in clinical practice With an increased uptake of genomic profiling in clinical practice and the evolving complexity of diagnostic modalities, vast amounts of complex data …

Read our ESMO recommendations on MTBs for precision medicine here: www.sciencedirect.com/science/arti...

Highly recommended!

We are hiring! www.nki.nl/careers-stud...
@nkinl.bsky.social

🤙🤙🤙 Precision oncology starter package

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease | NEJM Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access...

We live in exciting times

www.nejm.org/doi/full/10....

Cool concept

Imagine how many black and white pictures could have been published in full color

γδ T cells are the prime anti-tumoral T cells in pediatric neuroblastoma High-risk pediatric neuroblastoma patients have a dismal survival rate despite intensive treatment regimens. New treatment options are thus required. Even though HLA expression in neuroblastoma is low and immune cell infiltrates are limited, the presence of tumor infiltrating lymphocytes (TILs) is indicative for better patient survival. Here, we show that most tumor lesions contain viable immune cell infiltrates after induction chemotherapy, with high percentages of CD3+ T cells. We therefore expanded the TILs and tested their anti-tumoral activity. With sufficient starting material, TIL expansion was as efficient as for adult solid tumors. However, whereas TIL products from adult tumors almost exclusively contained αβ T cells, in neuroblastoma-derived TILs, γδ T cells expanded with similar efficacy as αβ T cells. Importantly, the anti-tumor responses in response to autologous tumor digest primarily originated from (Vδ1- and Vδ3-expressing) γδ T cells, and not from αβ T cells. In conclusion, this finding creates a window of opportunity for immunotherapy for neuroblastoma patients, with γδ T cells as potential prime responders. ### Competing Interest Statement The authors have declared no competing interest.

Magnificent work from Monika Wolkers and team : γδ T cells are the prime anti-tumoral T cells in pediatric neuroblastoma

Another case where γδ T cells are the central effectors of anticancer immunity.

www.biorxiv.org/content/10.1...

@forum-gd.bsky.social

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Big if true: do cancer cells transfer mutated mitochondria into tumor infiltrating lymphocytes to impair their function? mtDNA is challenging to work with, so looking forward to see this finding confirmed. But cool concept and big congrats to the authors!

www.nature.com/articles/s41...

2/2 The results seem pretty consistent across cohorts, robust to adjustment for confounded and not observed in treatments such as immunotherapy and chemotherapy which are not directed to specific mutations.

Congrats to our one and only Karlijn Verkerk for leading this effort!

1/2 Puzzling result from the DRUP study: the more mutations driving proliferation in a tumor, the less effect of targeting only one of them with specific drugs.

www.esmoopen.com/article/S205...

Genetic Analysis of a Sarcoma Accidentally Transplanted from a Patient to a Surgeon | NEJM Modern concepts of cancer immunology originated from the classic observations by Jensen, Loeb, Tyzzer, and Little in the early years of the 20th century of the rejection of transplanted allogeneic ...

Bizarre story.

Genetic Analysis of a Sarcoma Accidentally Transplanted from a Patient to a Surgeon | New England Journal of Medicine www.nejm.org/doi/full/10....

gary the snail from spongebob plays drums with the words ba dum tsss below him ALT: gary the snail from spongebob plays drums with the words ba dum tsss below him

How stupid

Vancomycin colored over to be a 🎄

Forget Die Hard vancomycin is a Christmas antibiotic

The best science images of 2024 — Nature’s picks A breathtaking total eclipse, courageous penguins, volcanic smoke rings and more.

Awesome www.nature.com/immersive/d4...

Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

Impressive www.science.org/content/arti...

Eleven clinical trials that will shape medicine in 2025 - Nature Medicine Nature Medicine asks leading researchers to name their top clinical trial for 2025, from gene therapies for prion disease and sickle-cell disease to digital tools for cancer and mental health.

🤩🤩🤩 www.nature.com/articles/s41...

Done! Welcome