Anubhav Prakash

Cell divisions both challenge and refine tissue boundaries in the Drosophila embryo Highlighted Article: A combination of mathematical modelling, in vivo quantitative microscopy, and pharmacological and biophysical manipulations reveals that cell divisions not only challenge, but als...

Check out our new publication @dev-journal.bsky.social! If you thought that cell divisions challenge tissue boundaries ... you got half of the story! Using in vivo quantitative microscopy and math. modelling we show that divisions fluidize tissues and facilitate boundary refinement. 🧪 #drosophila

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton - preLights The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin.

The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩

Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint

#preLight ⬇️
prelights.biologists.com/highlights/a...

Bhaval discusses our work to give an exploratory view on the forces driving epithelial diversity. Check it out!

Yes. Indeed.

This image here shows a 3D-rendered cristae from the mouse's inner ear. In red ♥️ is F-actin marking cell junctions and the 💙 is beta-Spectrin 2 marking the mechano-sensory hair cells. These are important for the sense of balance and linear acceleration.

Boris Shraiman points a physicist’s eye on biological quandaries Boris Shraiman is awarded the American Physical Society’s Max Delbrück Prize in Biological Physics.

Boris Shraiman points a physicist’s eye on biological quandaries news.ucsb.edu/2025/022264/... 🧪

My favourite gene, Vangl2 in action

Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!

Thanks a lot to co-authors for their contribution and Raj Ladher @earlab.bsky.social for his guidance. @ncbsbangalore.bsky.social and Ashoka University for the support.

Ever wondered how tissues have diverse organisations? We did with some experiments on sensory epithelia of 🐣 🐟 and 🐁. We found that these epithelia are initially very similar. As they develop, cell types acquire a solid/fluid-like mechanical state driving the cellular organisation. Comments welcome!

Kompartment Konnection: How the Cochlea Coordinates for a Perfect Design - BioPatrika Researcher Spotlight - Uncover how compartments integrate spatial and temporal cues across scales & how local cellular behaviours influence

#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab earlab.bsky.social at NCBS, Bangalore talks about his work on "Kompartment Konnection: How the Cochlea Coordinates for a Perfect Design" PLOS Biology biopatrika.com/academia/res... @ncbsbangalore.bsky.social

Cochlea generates patterns by interacting with neighbours We wanted to understand how cells arrange into precise patterns as the cochlea develops its spiral shape. We found that the cochlea is divided into smaller domains, each organising independently whil...

link.growkudos.com/1efpeb7d8n4 A short article is now available at Kudos on our work @earlab.bsky.social at @ncbsbangalore.bsky.social about how the cochlea generates its pattern.

@earlab.bsky.social

Computational image analyst (m/f/d) The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Editor's insightful commentary on our work in cochlear morphogenesis.

EMBO Molecular Medicine: Vol 17, No 9 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our September issue is online! www.embopress.org/toc/17574684...

On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...

Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

It was an adventurous quest. Aptly supported by @earlab.bsky.social @ncbsbangalore.bsky.social and Ashoka University. A big thanks to Sukanya, @ramankaushik.bsky.social, Pallavi and Anton for their contribution. Write to us for any query/know more!

We show the Organ of Corti is composed of adhesion-molecule based compartments and the interaction between these compartments (compartment coupling) drives pattern and polarity. This seems like a fundamental design principle of developing tissues.

Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells Author summary Hearing, like other sensory modalities, is essential for animals to perceive and interact with their environment. The cochlea, the auditory sensory organ, develops under tight genetic r...

#LatestPublication
In a latest study published in PLOS Genetics, Ramankaushik and team from Dr Raj Ladher's lab describe a new role for protocadherin-15 in patterning the hair cell.
🎉Congratulations to the team!

journals.plos.org/plosgenetics...

It was wonderful working with Julian, Sukanya, @earlab.bsky.social , Madan and Karsten. A big thanks to Ashoka University and @ncbsbangalore.bsky.social for their support.

preprint: Using a combination of experiments and theory, we show that force patterning at apical junctions drives three-dimensional spatial organisation in multi-cell-type epithelia. Give us your comments!

Pushing and pulling cells from chaos to order  - BioPatrika Researcher Spotlight - Pulling cells: Using a combination of experiments and mathematical modelling, we show that the tuned differences in the mechanical properties of junctions can organise cells int...

#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab @earlab.bsky.social, NCBS @ncbsbangalore.bsky.social talks about his work on "Pushing and pulling cells from chaos to order" biopatrika.com/academia/res... @natcomms.nature.com

Junctional force patterning drives both positional order and planar polarity in the auditory epithelia - Nature Communications Sound is sensed in the cochlea through a precisely organised epithelium. Prakash and colleagues show cellular organisation results from differences in junction contractility, finding mechanics is suff...

#LatestPublication in @natcomms.nature.com by
Dr Raj Ladher & team show that fine-tuned junctional mechanics are vital for aligning polarity in chicken cochlea.

🎉Congratulations to the team!
@prakash-patterns.bsky.social @earlab.bsky.social

Read here: www.nature.com/articles/s41...

Compartment coupling integrates patterning and morphogenetic information during development Morphogenetic information arises from a combination of genetically encoded cellular properties and emergent cellular behaviours. The spatio-temporal implementation of this information is critical to e...

It was absolutely amazing working at Raj Lab, @ncbsbangalore.bsky.social If you are thinking how our mammalian inner ear is patterned read our latest work doi.org/10.1101/2024...

Pushing and pulling align forces in the ear The physiological function of every organ depends on the molecular and morphological characteristics of constituent cells and the organisation of these cells into precise patterns. We explored, how ce...

If you wanna know how we reached there, look at the behind the scene blog post, communities.springernature.com/posts/pushin...

Using a combination of experiments and theoretical modeling we show differential junctional contractility governed by the phosphorylation state of myosin drives concomitant development of spatial organisation and planar polarity.

Junctional force patterning drives both positional order and planar polarity in the auditory epithelia - Nature Communications Sound is sensed in the cochlea through a precisely organised epithelium. Prakash and colleagues show cellular organisation results from differences in junction contractility, finding mechanics is suff...

My PhD work on the development of spatial organisation and planar polarity in avian auditory epithelia is now published @natcomms.nature.com doi.org/10.1038/s414...