The effects of genetic variants primarily occur in differentiated cells meaning we need to access these cell types to measure variant effects for most disease genes. We developed saturation genome editing in stem cells (iPSC-SGE) to enable phenotyping in diverse genetic and cell contexts at scale!
And, HUGE thanks to #ultima_genomics for making it possible! We can’t wait to integrate this data with fiber-seq and WGS to better understand why kids are born with heart defects, and actually find ways to prevent and/or treat it ❤️🩹
About 7 weeks ago, I told my lab that #ultima_genomics was willing to sequence cardiac organoid multiomes delivered by June 30. Josh, Megha and Lucy said… GAME.ON. And well, today they delivered 59 from various hiPSC lines, conditions and time points 💪🥳🧬 So proud of them for stepping up!
Frost: Tonight the people stealing are not folks with tattoos and hoodies but people wearing suits and ties and congressional pins sitting in the capitol now, not in some alley wrapped in darkness but the United States congress wrapped in the flag. It is disgusting and we will never forget this.
Good cover @economist.com
All NSF GRFPs to students choosing to attend Harvard in the Fall were just terminated
Bullying students and schools to provoke fear and silence dissent is how we trade democracy and freedom for authoritarianism. This will affect nearly a third of Harvard's students. We cannot be silent.
NSF GRFPs terminated for those in graduate school and already attending Harvard, too.
Vote for Megha Agarwal’s cardiac organoid ‘STEMCELLfie’ 🔬🧫❤️⭐️🤩 www.stemcell.com/stemcellfie
Go California! Please write to your representatives in the California Senate and ask them to support Mr. Scott Wiener's Bill.
www.politico.com/news/2025/03...
Look what's happening at the French Embassy in Washington DC.
NEW: Senator Marshall (R-KS) RUNS AWAY, fleeing his own town hall after being asked about DOGE firing Veterans. MAKE HIM GO VIRAL.
Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️
www.rarediseaseday.org
NEW: A searing editorial in the The Kyiv Independent.
“It’s time to say it plainly. America’s leadership has switched sides in the war. The American people have not, and they should speak up.
“A president just disrespected America in the Oval Office. It wasn’t Zelensky.”
@kyivindependent.com
Most #PhD scientists in the United States stay in the labor force notably longer than the average person—into their late 60s and in some cases beyond—according to new data from the National Science Foundation. scim.ag/4knpeWn
Graduating during the pandemic slowed down my process and is part of why I did two postdocs. Now as a first year faculty, all the federal grants are frozen. I love the work I do but this has all of us questioning how much www.science.org/content/arti...
A freeze on meetings of expert panels that peer review grant proposals at the National Institutes of Health is kicking in this week.
Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
#WomeninSTEM accelerate science and make our work possible. Today, we join other science organizations around the world by recognizing the International Day of Women and Girls in Science. #WomenInScienceDay
Just got the dreaded email. University of Iowa is halting all NIH grant submissions.
Losing a generation of scientists here will send the state backwards. What a travesty.
WORKING LIFE I was worried I didn't belong in science—until I discovered many researchers feel the same way
"Maybe impostor syndrome wasn’t a sign of failure, but a sign of growth."
This week's #ScienceWorkingLife. https://scim.ag/3QbA5oF
President Trump ended a first-of-its-kind assessment of land, water and wildlife across the U.S. that its leader called "too important to die," weeks before the study was set to be completed.
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
🚨 Excited to announce the Marker paper for the GREGoR Consortium! arxiv.org/abs/2412.14338
Accelerating #RareDisease diagnostics with cutting-edge #Genomics and global data sharing of omics and deep phenotyping from ~7500 individuals on NHGRI AnVIL and much more to come! 🧬
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
Introducing scE2G: a new model to link enhancers to target genes using single-cell data.
Excited that scE2G will enable building enhancer maps in hundreds of cell types in the human body!
Wonderful collaboration with @randersson.bsky.social @613weilin.bsky.social @mayayayas.bsky.social
Thread👇
