Simon Wiegert

Happy to have contributed to this beast of a paper with some optogenetics and fiber photometry.

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

Kudos to everyone involved for pushing the boundaries of what we can see in the brain🚀
Check out the full paper here: doi.org/10.1038/s415...
Christopher Ford Andrew Yee @anitaluthi.bsky.social @labluthi.bsky.social @simwieg.bsky.social @FellinLab @ruemcclammyhand.bsky.social digersarah.bsky.social

Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...

Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science www.science.org/doi/10.1126/...

Hier geht es nicht um Ehre, sondern um die Personen, die das Jahr besonders geprägt haben - positiv wie negativ. 1938 war es Adolf Hitler

Inaugural lecture to the faculty of Yasin Dagdas (@plantophagy.bsky.social) and Simon Wiegert (@simwieg.bsky.social) - bridging green and red biology.

Dopamine ≠ reward but turns out, also not the learning molecule we thought.

If DA RPE is the emperor, this work SCREAMS it was running naked all the time.

This paper got quite some attention recently. Let's simplify it a bit.

A🧵with my toy model and notes:

#neuroskyence #compneuro #NeuroAI

The sour taste component is likely due to oxidation of water at the anode during electrolysis. This generates protons that can be directly sensed by taste cells through H+ activated cation channels. But that's just my guess ;)

...been doing this already a lot ;) Very easy

Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).

Congrats! This is really cool. Very nice paper with lots of thorough analyses and important side findings.
It is also a great use case for BiPOLES. Something we have envisioned when designing this tool.🙌 Well done 🙌

🚨 8 PhD positions in GPCR signaling! The research group “DynOrg"(‪@dfg.de‬, @simwieg.bsky.social) is hiring doctoral researchers to study how GPCRs shape brain, heart & behavior – combining optogenetics & physiology. 🌍 7 labs across Germany

🗓️ Apply by Aug 31, 2025
👉 www.for5807.de/en/open-posi...

New Research Unit in Basic Biomedical Research: German Research Foundation provides approx. five million euros in funding www.uni-heidelberg.de/en/newsroom/...

Ilustration for FOR5807 showing sketches of c. elegans and its neuronal networks and molecular form of serotonin and dopamin

🚀 Big news from our @monikakscholz.bsky.social lab! We’re part of DynOrg, a new @dfg.de-funded Research Unit exploring how #GPCR signaling coordinates organ function & animal behavior — from heartbeat to foraging. 🧠💓
#FOR #neurotransmitters

Led by @simwieg.bsky.social from @uniheidelberg.bsky.social, DynOrg is one of 7 new DFG Research Units, supported for up to 8 years. We're thrilled to be on board! 🔬🇩🇪
#GPCR #Neuroscience #DynOrg #DFG #WormLab

A must-read (in my humble opinion :)) if you plan to target the locus coeruleus in the rodent system. Selectivity and specificity strongly vary between strategies and mouse lines. But no need to worry: we provide tools and strategies to overcome those limitations.

Die DFG richtet 7 neue Forschungsgruppen ein Das Fördervolumen für die Neueinrichtungen beträgt insgesamt 33,4 Mio. Euro für die erste Förderperiode inkl. je 22 % Programmpauschale für indirekte Projektausgaben. 3 Forschungsgruppen werden um eine weitere Förderperiode von vier Jahren verlängert.

Förderentscheidungen zu #Forschungsgruppen durch den Hauptausschuss der DFG im Rahmen der Jahresversammlung: 7 Neueinrichtungen, 3 Verlängerungen. Die neuen Forschungsgruppen erhalten insges. rund 33 Mio. € für die erste Förderperiode. Mehr zu den Themen / Institutionen: www.dfg.de/de/service/p...

Lab outing 2025. Beautiful weather, beautiful wine, beautiful people

🎉Congratulations Heidelberg University!👏
📣With three successful Clusters of Excellence applications, Heidelberg can compete again for the status as a University of Excellence‼️
The existing cluster 3DMM2O will receive further funding, plus the new initiatives SynthImmune & GreenRobust.
#Excellence

Every lab should have a Bell of Glory. Here is ours and it sounds great

Researcher Subcellular Optogenetics at the Neurosciences Research Center DM.65.25 part-time | 28.03.2025 | Campus Charité Mitte

🚨We have an open position in the lab for the engineering of new #optogenetic tools for light control of #subcellular biology!💡🧠🔬 Interested? Get in touch or apply 👍

karriere.charite.de/en/job-vacan...

Functional Connectivity Shapes Spine Stability in the Hippocampus https://www.biorxiv.org/content/10.1101/2025.02.07.637112v1

Schaffer commissural inputs regulate the stability of CA1 spatial representation Neuronal representations of the world are dynamic. A striking example is the rapid remapping of the hippocampal spatial code, which occurs even when the environment and behavior remain unchanged. Here...

Looks great. Will have to read immediately to see if it fills the holes in our recent one ;) www.biorxiv.org/content/10.1...

Screenshot from Fig. 1c of the paper in the link.

Cool experimental design by @simwieg.bsky.social's lab with optogenetics + calcium imaging: how place cells in CA1 are affected by stimulation of contralateral CA3. They observe less an induction of place fields but somewhat random shifts of existing place fields: www.biorxiv.org/content/10.1...

Schaffer commissural inputs regulate the stability of CA1 spatial representation Neuronal representations of the world are dynamic. A striking example is the rapid remapping of the hippocampal spatial code, which occurs even when the environment and behavior remain unchanged. Here...

www.biorxiv.org/content/10.1...

A major step forward in elucidating the relationship between synaptic plasticity at individual hippocampal synapses and neuronal encoding of external information in the living brain.

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov

On the way to Berlin to celebrate Peter Hegemann's 70th birthday with a surprise symposium (he's not yet on bsky - no risk of spoiling it).
Looking forward to seeing many friends from all over the world. Peter has been a central figure in building this community.
#optogenetics

(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why

A low-cost perfusion heating system for slice electrophysiology - Scientific Reports Scientific Reports - A low-cost perfusion heating system for slice electrophysiology

Are you building a patch-clamp setup, and would like a cheap heating system? Have you ever wondered how temperature changes the membrane properties of MSNs? Then you might like our latest paper, out now!

www.nature.com/articles/s41...

...I used to be one, too 😅