Collab btwn NIAID (Dr. Andrea Marzi’s lab) and HDT Bio just published! 🧪
Filovirus gold-standard VSV vax platform compared to LION/repRNA (each encoding same antigen seq) for ability to provide single-dose protection in guinea pigs against Sudan virus challenge 🧵(1/2) www.nature.com/articles/s41...
Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.
www.thelancet.com/journals/ebi...
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Looks like #Uganda will use #IAVI's #Ebola Sudan vaccine in a clinical trial aimed at helping to halt the country's outbreak. The trial could also provide evidence of the vaccine's efficacy. As I reported y'day, there are already doses in Uganda — 2160, in fact. www.who.int/news/item/31...
Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques
www.nature.com/articles/s41...
Would love to be added if possible!
When you design a vaccine and by the time the paper comes out you’ve made three updated versions as the virus continues to evolve 😅 #influenza #RNAviruses
