Helgason Lab

A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemia Key Points. Nutrient sensing drug-repurposing screen identifies itraconazole, an FDA-approved azole antifungal, as a mitochondrial metabolism inhibitorItra

Hot off the press from @helgasonlab.bsky.social ashpublications.org/blood/articl...

Thanks to all the local colleagues at
@uofgcancersciences.bsky.social @glasgow.ac.uk @cruk-si.bsky.social and international collaborators who played an essential role in this work!

And many thanks to funders including
@bloodcanceruk.bsky.social and @cancerresearchuk.org

#BloodCancerResearch

A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemia Key Points. Nutrient sensing drug-repurposing screen identifies itraconazole, an FDA-approved azole antifungal, as a mitochondrial metabolism inhibitorItra

Delighted to share our publication in
@bloodjournal.bsky.social where we describe the identification of antifungal itraconazole as a potent inhibitor of mitochondrial metabolism in AML

Great effort by joint first authors Katerina Himonas and Lucie de Beauchamp.

ashpublications.org/blood/articl...

Happy holidays from the Helgason Lab. Wishing everyone has a wonderful festive break 🎄🎅🤶

Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth

Located at the Wolfson Wohl Cancer Research Centre and CRUK Scotland Institute, in Glasgow.

Supervisory team: @helgasonlab.bsky.social Daniel Murphy, Peter Hall, Kevin Blyth, Bodhayan Prasad

Deadline: 30th June

CRUK Scotland Centre - Investigating Asbestos exposure and other environmental factors underpinning Lung cancer inequalities in the Scottish population at University of Glasgow on FindAPhD.com PhD Project - CRUK Scotland Centre - Investigating Asbestos exposure and other environmental factors underpinning Lung cancer inequalities in the Scottish population at University of Glasgow, listed o...

PhD opportunity (open to UK-Students only):

Interested in PhD project where you investigate environmental factors driving lung cancer inequalities?

The project allows you to learn computational and lab experimental approaches

Deadline: 30th June

Please share!
www.findaphd.com/phds/project...

Networking…

Great trip to Iceland for this year’s Lab Retreat. Stimulating science discussion at the University of Iceland, followed by networking and some sightseeing 🚐 🌬️🌈 🇮🇸
Team and landscape photos below 👇👇👇

Fantastic Martha - congrats again!!!

We are looking for a Research Associate to join the Mitochondrial Oncogenetics (@mito-oncogene.bsky.social) lab and investigate the impact of mitochondrial DNA on tumour microenvironments

📅Closing date: 7 February 2025

👉Find out more and apply here: www.crukscotlandinstitute.ac.uk/careers/scie...

Research Assistant/Associate Position in the lab. Fully funded until February 2028. Please apply if you are passionate about inter-organ signalling and intestinal biology...And off course, our wonderful Drosophila!

Position details and application link below

www.jobs.gla.ac.uk/job/research...

Save the date!
Hope to see you in Dundee in June.

We hope all friends and colleagues will have a well deserved break during the festive season 🎄
We certainly had fun during our Western themed Christmas lunch 🤠