John Witte

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ...

Our latest preprint revisits the classic model of mutation-selection balance.

Do human recessive genes fit Haldane's 100-year old model?

This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io

www.biorxiv.org/content/10.6...

Yes I’m here for the term. Will see you shortly!

Looking forward to your talk!

The PRIMED Consortium: Reducing disparities in polygenic risk assessment By improving disease risk prediction, polygenic risk scores (PRSs) could have a significant impact on health promotion and disease prevention. Due to …

Check out the latest review on PRS assessment from the #PRIMEDConsortium

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www.sciencedirect.com/science/arti...