Rezvani Lab

👍 #oilpainting #sketchbook

Neue Einblicke in die Immunzellen der Leber - Aktuelles - BIH at Charité Die Leber spielt eine zentrale Rolle im Stoffwechsel und in der Immunregulation des Körpers. Dennoch sind viele zelluläre Mechanismen, die bei Lebererkrankungen eine Rolle spielen, bislang erst in Ans...

@berlinliverlab.bsky.social im Interview über Einblicke in die Immunzellen der Leber & neue Therapien 💬💉

www.bihealth.org/de/aktuell/n...
Foto © Charité

Modeling Immune Lineage Co-Development in Human Pluripotent Stem Cell-derived Liver Organoids Intercellular orchestration across hepatic and immune lineages governs critical liver development and disease processes. Existing in vitro human liver…

Human liver organoids with their own immune system — now possible!

We reconstruct the fetal hematopoietic niche in organoids + explore how neutrophils link to hepatocyte fat buildup
@jhepatology.bsky.social
@bihatcharite.bsky.social
www.sciencedirect.com/science/arti...

From form to function – how liver cells mature A new study by the Meissner and Hnisz labs, published in Developmental Cell, reveals in new detail the genetic programs that guide liver cells as they develop into fully functional hepatocytes. The fi...

A new study by the Meissner and Hnisz labs, published in Developmental Cell, reveals the genetic programs that guide liver cells as they develop into fully functional hepatocytes. The findings could have implications for biotechnology and regenerative medicine.
--> www.molgen.mpg.de/2025-11-27-f...

Proud of my outstanding PhD students!

Independent of me, @julianweihs.bsky.social & Susanna Quach assembled with students from the Wagner lab in Berlin and won a Pitch Award for their idea to remove microplastics from cells.
@bihatcharite.bsky.social @einsteinberlin.bsky.social

Human liver immunology: from in vitro models to new insights - Cellular & Molecular Immunology Cellular & Molecular Immunology - Human liver immunology: from in vitro models to new insights

The liver balances immune tolerance and inflammation—but most liver models don’t.

In this new review, I break down human-specific systems to study liver–immune crosstalk.

From cocultures to organoids.

www.nature.com/articles/s41...

@bihatcharite.bsky.social

Congrats!!!

"Science is an investment.

We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."

— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

After every encounter with the current scientific publishing system

So much fun at the @berlinliverlab.bsky.social outing — from laser tag battles to beers in the Berlin evening sun. Grateful for this brilliant, fun, and inspiring team! #LabLife #BerlinVibes @bihatcharite.bsky.social

Who funds biomedical research? @nature.com
www.nature.com/articles/d41...

Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine Nature Reviews Gastroenterology & Hepatology, Published online: 26 February 2025; doi:10.1038/s41575-025-01048-wMetabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous disease regarding its pathophysiology and clinical…

New online! Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine

Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment Nature Reviews Gastroenterology & Hepatology, Published online: 17 February 2025; doi:10.1038/s41575-025-01045-zThis Review discusses the link between metabolic dysfunction-associated steatotic liver disease (MASLD) — a heterogeneous health condition —…

New online! Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment

A Novel Three-in-One Pancreatic Organoid An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration.

Check out this new article highlighting our postdoc @amandaanderssonr.bsky.social ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: www.the-scientist.com/a-novel-thre...

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis - Nature Genetics This study identifies candidate safeguard repressor transcription factors that repress alternate lineages in mature cell types and provides functional evidence that Prox1 performs such a function in h...

interesting.

Is PROX1 —a well established factor in liver development— also maintaining liver cell identity long after birth?

www.nature.com/articles/s41...

Pictures of Lise Meitner Group leaders: Sofie Valk, Flore Kunst, Anna-Maria Meister, Maria Sokolova, Heidi Colleran, Nathalie Feiner und Ulrike Kraft.

A new round of the Lise Meitner Excellence Program for #tenuretrack group leaders opened today - please consider applying! The program aims to recruit and promote exceptionally qualified female scientists. www.mpg.de/lise-meitner... #LiseMeitnerGroups #WomeninScience #ScienceCareer

(S+) Deutschland und Donald Trump: Max-Planck-Gesellschaft wirbt um US-Spitzenforscher Ist Deutschland am Ende Nutznießer von Trumps Feldzug gegen die Wissenschaft? Die Max-Planck-Gesellschaft meldet viel mehr Bewerbungen aus den USA als früher. Präsident Patrick Cramer will dort geziel...

Die neue US-Administration schränkt die #Forschungsfreiheit ein – Förderanträge werden nicht geprüft, Mittel eingefroren. Das betrifft auch viele unserer Partner. Umso wichtiger ist es, den transatlantischen Austausch zu stärken. Gespräch im @spiegel.de u.a. dazu (€): www.spiegel.de/wissenschaft...

OpenAI’s ‘deep research’ tool: is it useful for scientists? The model produces cited, pages-long reports that might be helpful for generating literature reviews.

Has writing scientific reviews just become obsolete?

…because AI does it better?

www.nature.com/articles/d41...

@maxplanck.de

Europeans strongly support science and technology according to new Eurobarometer survey The latest Eurobarometer survey on ‘European citizens' knowledge and attitudes towards science and technology' released today shows more than 8 in 10 citizens (83%) think that the overall influence of...

What do Europeans think of science and technology?

- 83% believe science and tech have a positive impact,
- 67% say science makes life easier, healthier and more comfortable,
- 58% want to learn more about scientific advances.

Find out more in the new Eurobarometer.
ec.europa.eu/commission/p...

Hello, Bluesky! ☀️

We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.

Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

Lively discussions on Metabolic dysfunction-associated steatotic liver disease (MASLD) with scientists from Berlin and Dresden at Charité Berlin Crossover.

#BerlinInstituteofHealth #BIh
#TechnischeUniversitätDresden
#LiverResearch #MASLD #BerlinScience #Collaboration #Charité

Cover letter when you're missing the mechanism

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial - Nature Aging Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive prote...

🔔I take care of kids, not geriatrics, and I’m skeptical of the tech-bro #longevity obsession—but this study seems cool and cost-efficient!

If true, it suggests taking Vitamin D, algae-based Omega-3 + exercising 3x/week slows molecular aging by 3-4 months. Not bad!

www.nature.com/articles/s43...

Preventing the progression of cirrhosis to decompensation and death Nature Reviews Gastroenterology & Hepatology, Published online: 27 January 2025; doi:10.1038/s41575-024-01031-xThis Review describes the progression of advanced chronic liver disease (ACLD) from its early stages (compensated ACLD) to more advanced disease…

ICYMI: New online! Preventing the progression of cirrhosis to decompensation and death

Could fully biologic tissue-engineered blood vessels be the future of coronary bypass?

Promising work by Park et al. shows antithrombotic function & graft patency using hiPSC-ECs.

Thoughts?

www.cell.com/cell-stem-ce...

#RegenerativeMedicine #VascularBioengineering

Will there be a scientific Exodus to Germany from the US?

#NIH
#Trump
@maxplanck.de
@www.helmholtz.de
@harvard.edu
@harvardchanschool.bsky.social

ETH Zurich researcher aims to prevent urinary tract infections with a vaccine Every second woman and every eighth man suffer from urinary tract infections. These are painful and can recur with serious health consequences. Pioneer Fellow Giorgia Greter has a solution.

Encouraging.

Towards developing a new vaccine for urinary tract infections #UTIs.

I wonder if also applicable to children where #UTIs are a big problem

@ethzurich.bsky.social

ethz.ch/en/news-and-...

an alien with lipstick or a zebra fish heart.

both amazing

AAVs are already used clinically🩻

This seems like a useful resource to make your experiments for translational

Engineered heart muscle allografts for heart repair in primates and humans - Nature Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading ...

mind. blown.

these peeps transplanted a bioengineered patch made from iPSCs and stromal into primates and a human and saw evidence for remuscularization.

www.nature.com/articles/s41...