Sreeganga Chandra Lab at Yale

How Gene Mutations Drive Dementia in Parkinson’s Disease New findings reveal motor and cognitive deficits arise through separate mechanisms in Parkinson’s disease, challenging previous thinking.

See also this great write-up from @yaleschoolofmed.bsky.social about this work! medicine.yale.edu/news-article...

Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies - Nature Communications GBA, a major gene for Parkinson’s disease and dementia with Lewy bodies, is associated with increased risk of developing dementia. Here, we demonstrate that GBA mutations in mice contribute to cognitive deficits through α-synuclein-independent mechanisms that impact synaptic vesicle endocytosis.

Our paper exploring the link between cognitive deficits and GBA mutations in Parkinson's disease is out now in Nature Communications. Congratulations to @vidyadharadj.bsky.social and all of the authors on the success of their hard work! www.nature.com/articles/s41...

It was an honor for PhD students @mallnutt.bsky.social and @leaheharmon.bsky.social to be part of the Connecticut contingent at last week's Parkinson's Policy Forum Hill Day run by the Michael J Fox Foundation and @apdaparkinsons.bsky.social to advocate for funding for Parkinson's research!

Had a wonderful & engaging meeting at Grand Challenges in Parkinson's disease earlier this month! It was good to see lab alumni Jamie and Mike @hndlab.bsky.social !

Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th

From Parkinson’s Foundation Research Center to Powerhouse: How Yale Became a Leader in Parkinson’s Science

Thank you to @pfresearchteam.bsky.social for this story highlighting the work we've been doing at Yale with @pdc-lab.bsky.social ‪and Dr. Shawn Ferguson's lab as a Parkinson's Foundation Research Center! www.parkinson.org/blog/researc...

The lab had a wonderful time visiting the new neuroscience exhibit at the Yale Peabody museum! Congratulations to curators April Pruitt, @dacolon.bsky.social , and everyone who worked on this exciting exhibit!

On #RareDiseaseDay, we want to recognize patients with Neuronal Ceroid Lipofuscinosis (NCL) and their families. Graduate student Alex Esqueda and recent grad Dr. Sofia Tieze are working to improve our understanding of the pathogenesis of these rare and devastating diseases.

Excited to be at the organization meeting for the 2026 World Parkinson Congress- save the dates! #WPC2026 @worldpdcongress.bsky.social