Alon Keinan

Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution The North Sea's historical migrations have impacted the genetic structure of its neighbouring populations. We analysed haplotype sharing among 858,635 modern individuals from Denmark and Britain to in...

We have updated our preprint about 850,000 person UK-Danish haplotype sharing - sheding light on the rich history each person carries with them in their DNA and comparing this to historical records. Xiaolei Zhang postdoc in my group led this work. www.biorxiv.org/content/10.1...

📣 Happy to share our review on host-microbiome genomics!

We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes

Out now in Nature Reviews Genetics👇

www.nature.com/articles/s41...

We're thrilled to introduce PromoterAI — a tool for accurately identifying promoter variants that impact gene expression. 🧵 (1/)

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Nature Communications Here the authors identify hundreds of genetic loci linked to 36 traits in East Asians, revealing population-specific associations and emphasizing the importance of diverse ancestry groups in genome-wi...

Now published! Congrats Yon Ho on this huge lift conducting dozens of GWAS in Korea and performing meta-analyses with other Asian biobanks reaching a sample size comparable to UK Biobank. The fine-mapping, novel loci, and ancestry-enriched discoveries are very cool. www.nature.com/articles/s41...

Guess so.. I remembered wrong the exact derivation

The Allele Frequency Spectrum in Genome-Wide Human Variation Data Reveals Signals of Differential Demographic History in Three Large World Populations AbstractWe have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-

academic.oup.com/genetics/art...

1/n 🚨Very excited to share our recent work!🚨
To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures in vitro.
www.biorxiv.org/content/10.1...

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans Interbreeding between anatomically modern humans and archaic hominins has contributed to the genomes of present-day human populations. However, our understanding of the specific gene regulatory conseq...

Preprint: Mapping the gene regulatory landscape of archaic hominin [Denisovan & Neanderthal] introgression in modern Papuans
By @maddycomerford.bsky.social et al. w/ @ee-reh-neh.bsky.social
@biorxiv-evobio.bsky.social
www.biorxiv.org/content/10.1...

Fine-mapping in admixed populations using CARMA-X, with applications to Latin American studies CARMA-X is a robust fine-mapping method for admixed populations, leveraging ancestry-specific data to identify putative causal variants. By modeling cross-ancestry correlations and accounting for LD v...

📣New from Yang et al.
📄Fine-mapping in admixed populations using CARMA-X, with applications to Latin American studies
www.cell.com/ajhg/abstrac...

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓

Link: rdcu.be/efacK

Thread below 👇🏽

Eric Green is out as head of National Human Genome Research Institute The longtime director of the National Human Genome Research Institute is stepping down, as the larger NIH braces for more changes.

The longtime director of the National Human Genome Research Institute is stepping down, as the larger NIH braces for more changes.