Natalie Krahmer

“The barriers women face are not about ability — they never were” 🧪

#Academia in Sweden is still male-dominated at senior levels, but this can be changed if organizations take this seriously, says equality expert Lauri Robbins-Ericson ↓
www.scilifelab.se/news/lauri-r...

#IWD2026 #WomenInSTEM

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

Aspartate availability drives differential engagement of the malate-aspartate shuttle Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

Congratulations Julia! Wonderful work!

Excited to share our speakers for the 4th Metabolism in Health & Disease conference!

It's a fantastic line up already, but we welcome new ideas & applications too💡⚡

If you have a story to tell or a new perspective to learn from, we want to hear from you - submit by 13 April 2026 ➡️ bit.ly/45CT3MY

‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏

📆Save the Date📆

Our Metabolism in Health & Disease conference returns from 10-13 Oct 2026 - this time in Portugal!

Keep informed about speaker announcements, grant & abstract opportunities by signing up for updates here: bit.ly/MHD26-SaveTh...

@petemullen.bsky.social @annakrook.bsky.social

thank you Atul!

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels - Nature Methods C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

🚀 Excited to share new work from Daniel Haas. In collaboration with Jan Hasenauer and Daniel Weindl within
@batenergy.bsky.social we've developed a software tool to map protein and lipid localization in cells, making spatial biology more accessible
www.nature.com/articles/s41...

🔗To the original publication: www.nature.com/articles/s41...

@nataliekrahmer.bsky.social @diabresearch-dzd.bsky.social @unibonn.bsky.social

C-Compass – Ai-Based Software Maps Proteins and Lipids Within Cells

C-Compass – Ai-Based Software Maps Proteins and Lipids Within Cells

Developed by #HelmholtzMunich, DZD & University of Bonn, C-COMPASS makes spatial proteomics & lipidomics easier to use – no coding needed.

👉 t1p.de/2gn5c

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Prot...

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science

doi.org/10.1016/j.ce...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, ...

There a lot of use of NAD+ supplements out there, without evidence of anti-aging effects in people. Here's some new data that detracts from NAD's role in modulating the aging process
www.cell.com/cell-metabol...

On becoming an autocracy @newyorker.com
www.newyorker.com/magazine/202...

Leading Nutrition Scientist Departs N.I.H., Citing Censorship (Gift Article) Kevin Hall said his work on ultraprocessed foods has been “hobbled” under the Trump administration. Scientists have been raising such concerns for months.

My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...

I am a professor at Columbia University. All of the student NIH training grants have been canceled and now there are reports that ALL funding will be frozen. Why are Universities not banding together and speaking out publicly and forcibly about governmental attacks on biomedical research?

😢 this is not normal. And we should not turn away from this illegal BS!

“It is up to all of us to fix this. It’s not going to be because somebody comes and saves you.” - President Obama yesterday

We must organize the pro-democracy majority to reclaim its power. Join an event near you for tomorrow’s nationwide day of action: handsoff2025.com?SQF_SOURCE=i...

Helmholtz-Präsdient Otmar D. Wiestler (links) und Bundesminister Cem Özdemir bei einer Pressekonferenz in Berlin.

Helmholtz-Präsdient Otmar D. Wiestler (links) und Bundesminister Cem Özdemir bei einer Pressekonferenz in Berlin.

Helmholtz-Präsdient Otmar D. Wiestler (links) und Bundesminister Cem Özdemir bei einer Pressekonferenz in Berlin.

Helmholtz-Präsdient Otmar D. Wiestler (links) und Bundesminister Cem Özdemir bei einer Pressekonferenz in Berlin.

Eine freie Wissenschaft gehört zum Kern liberaler, demokratischer Gesellschaften.

Es ist in höchstem Maße besorgniserregend, dass die Freiheit der Wissenschaft in verschiedenen Regionen der Welt zunehmend unter Druck gerät.

With everything happening in the US right now, how safe are scientific conferences for foreign participants in the US? I think this is something we have to discuss as a scientific community. I am hesitating to register for US meetings due to the unpredictable situation. Others who feel the same?

Beautiful, powerful letter

I have been asked by Harvard colleagues if they should keep quiet so as not put the larger Harvard community at risk with their words

Took me a while to ruminate

My response:

Harvard is its people and their voices

If we are silent then there is no Harvard to save

Pex30-dependent membrane contacts sites maintain ER lipid homeostasis In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment rema...

While, in a nice collaboration with the Carvalho lab and @joanavferreira.bsky.social, PhD student Yara Ahmed used MD simulations to characterize the binding mechanism of the Dysferlin domain of Pex30 to phosphatidic acid. Anyone interested in a novel PA-sensor? (2/2)
www.biorxiv.org/content/10.1...

It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

Time to fight !

Why are the Democrats so spineless? | Moira Donegan No wonder the American public thinks of Democrats as out of touch, opportunistic and cowardly. That is because they are

@moiradonegan.bsky.social: „Now, the Democrats seem less like a resistance than an acquiescence. They are not mounting any meaningful opposition to Trump’s aggressive, sadistic mission. Instead they’re rolling over, like a submissive dog showing its belly, …“ www.theguardian.com/commentisfre...

Congratulations!