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Barbara Ghiglione

@barbaraghi

Researcher at CONICET, Universidad de Buenos Aires, Argentina. #AMR #WASTEWATER #KLEBSIELLA

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21.11.2024
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Latest posts by Barbara Ghiglione @barbaraghi

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Life Identification Numbers: A bacterial strain nomenclature approach Unified strain taxonomies are needed for the epidemiological surveillance of bacterial pathogens and international communication in microbiological research. Core genome multilocus sequence typing (cg...

Huge preprint if you are interested in bacterial strain taxonomy! The why and how of cgMLST LIN codes: An extensively revised and expanded version doi.org/10.1101/2024... I will summarize it for you in this thread πŸ‘‡

30.11.2025 19:51 πŸ‘ 60 πŸ” 36 πŸ’¬ 3 πŸ“Œ 2
Overview of paper revealing role of arginine in regulating K. pneumoniae mucoidy.

Overview of paper revealing role of arginine in regulating K. pneumoniae mucoidy.

Our paper reporting a highly conserved mechanism by which arginine positively regulates hypervirulent K. pneumoniae mucoid phenotype is now fully online.
rdcu.be/euiWG

Summary picture is below, but details in the 🧡

01.07.2025 14:27 πŸ‘ 52 πŸ” 24 πŸ’¬ 3 πŸ“Œ 3
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Este 10 de abril, saludamos a quienes investigan, y en este marco, a pensarse como trabajadores. Tiene que haber un horizonte comΓΊn entre quienes investigan y el resto de los trabajadores. Porque sin ciencias no hay futuro deseable. Y sin condiciones dignas, no hay ciencias.

10.04.2025 11:07 πŸ‘ 8 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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Este 20 de febrero se cumple un nuevo aniversario del nacimiento del cientΓ­fico y pensador Rolando GarcΓ­a.

Doctor en MeteorologΓ­a, vicepresidente fundador del CONICET, cofundador de la Universidad Nacional del Sur,y recordado decano de Exactas en la UBA entre 1957 y 1966.

20.02.2025 12:54 πŸ‘ 5 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Pasteur Course: Tuberculosis 🧫
Join a 2-week intensive course at the Institut Pasteur from June 2–13, 2025 to gain expertise in TB diagnosis, treatment & epidemiology. Including hands-on trainings & insights from leading experts.

Limited to 20 participants - apply by March 1, 2025 πŸ‘‰bit.ly/3Cr0ift

21.01.2025 16:38 πŸ‘ 13 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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🌊 Food Traceability Using Genomic Tools 🧬

Join us for an online course with @marianilab.bsky.social & @shump.bsky.social , in February, to learn how cutting-edge genomic technologies (@illumina, @nanoporetech.com & qPCR) are revolutionising seafood traceability and sustainability
shorturl.at/Wsdyz

22.01.2025 14:49 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

✨ Apoyan: @okfn.bsky.social, @nerdearla.bsky.social, @latambioimaging.bsky.social, UNC CCAD Supercómputo, Conectorial, LA-CoNGA Physics, ILDA, R-Ladies Buenos Aires, @abrir.bsky.social, PsiNet Lab, ARPHAI, DiploCientífica.
Β‘Gracias por acompaΓ±arnos! πŸš€

23.01.2025 16:13 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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🚨 GLLVMs: Advanced Multivariate Analysis of Ecological Communities in R with @vdveenb.bsky.social 🚨
πŸ“… 20-23 May
Learn to master Generalized Linear Latent Variable Models (GLLVMs)-a cutting-edge, flexible alternative to classical ordination methods for ecological data analysisπŸ“Š
shorturl.at/WfdXK

22.01.2025 11:06 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1

What do you think are the critical features pathogen genomic data-sharing platforms require to meet the public health need? Please participate in this public consultation!

17.01.2025 11:14 πŸ‘ 9 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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A phylogenetic approach to comparative genomics Nature Reviews Genetics - Controlling for phylogeny is essential in comparative genomics studies, because species, genomes and genes are not independent data points within statistical tests. The...

Our review is out in Nature Reviews Genetics! rdcu.be/d5AY2

We show how phylogeny-based methods can resolve the problem of non-independence in genomic datasets.

These methods must be considered an essential part of the comparative genomics toolkit.

@lauriebelch.bsky.social @stuwest.bsky.social

08.01.2025 13:19 πŸ‘ 194 πŸ” 95 πŸ’¬ 5 πŸ“Œ 4

Join us for a new season of #KlebCkub! @klebclub.bsky.social
New speakers & new research!
Registration is FREE but mandatory.
Abstracts due by February 16!
Please share !
Link belowπŸ‘‡πŸ»πŸ‘‡πŸ»

09.01.2025 06:18 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Replay - Klebsiella Epidemiology and Biology Symposium 2024 Klebsiella Epidemiology and Biology Symposium 2024

#KLEBS2024 replay now available at www.klebs-2024.conferences-pasteur.org/replay - great opportunity to catch-up about #Klebsiella or to relive the conference - enjoy!

03.01.2025 17:11 πŸ‘ 12 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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Home A tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler

New year, new assemblies!
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)

31.12.2024 23:43 πŸ‘ 156 πŸ” 97 πŸ’¬ 2 πŸ“Œ 3
Line graph titled "Reported paralytic polio cases and deaths, United States, 1910 to 2019." The graph displays two lines: one representing the number of reported polio cases and the other indicating reported deaths over the years. The case count peaks in the 1950s, with deaths showing a similar trend. The x-axis represents the years (1910 to 2019), while the y-axis shows the number of cases and deaths.

Line graph titled "Reported paralytic polio cases and deaths, United States, 1910 to 2019." The graph displays two lines: one representing the number of reported polio cases and the other indicating reported deaths over the years. The case count peaks in the 1950s, with deaths showing a similar trend. The x-axis represents the years (1910 to 2019), while the y-axis shows the number of cases and deaths.

Good day to recall some milestones in US polio history

1953 Worst recorded US outbreak kills more than 3000
1955 First polio vaccine licensed
1979 Polio considered eliminated from the United States
1994 Polio considered eliminated in North and South America

ourworldindata.org/grapher/repo...

13.12.2024 19:15 πŸ‘ 131 πŸ” 48 πŸ’¬ 8 πŸ“Œ 3

Really exciting development from the @pathoplexus.org team, with a new curated database for mpox genomic data.

Glad to see these rapid data sharing efforts taking shape, guided by consistent, transparent governance and an ongoing commitment to equity and fairness.

10.12.2024 01:20 πŸ‘ 16 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Today Pathoplexus announces the inclusion of a new viral pathogen: mpox (previously known as monkeypox).

Within the context of the current mpox outbreaks and ongoing health concerns, Pathoplexus aims to support sequence sharing to improve both understanding and response.

1/7

09.12.2024 19:15 πŸ‘ 82 πŸ” 38 πŸ’¬ 2 πŸ“Œ 6
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🚨 We’re thrilled to kick off the eDNA Metabarcoding course, funded by @ednacollab.bsky.social! 🌍 Researchers worldwide are joining us this week to learn how to analyse their eDNA data with guidance from an exceptional team of instructors.
@leeselab.bsky.social @shump.bsky.social

09.12.2024 13:52 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 2

I started an #eDNA starter pack as one didn’t exist yet. Feel free to message me to get your name added. Open to all! go.bsky.app/U2vgV5Q

17.11.2024 07:23 πŸ‘ 112 πŸ” 58 πŸ’¬ 61 πŸ“Œ 3
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Please join us at 13:00 CET December 12th for the next edition of the IPSN webinar series 'Pathogen Genomics in Health Emergencies' to hear how genomics can contribute to the understanding of Cholera outbreaks. Register here:

04.12.2024 12:12 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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A chromosomal mutation is superior to a plasmid-encoded mutation for plasmid fitness cost compensation Plasmids spread important traits in microbiomes but impose fitness costs on their hosts. This study of the ecological consequences of plasmid-bacterial compensatory evolution reveals benefits to bacte...

How best to avoid the costs of bearing a #plasmid? Rosanna Wright @brockhurstlab.bsky.social @jpjhall.bsky.social &co find that #bacteria benefit from compensating plasmids by chromosomal (rather than plasmid-borne) mutations @plosbiology.bsky.social plos.io/3ODbXdN

03.12.2024 12:19 πŸ‘ 29 πŸ” 14 πŸ’¬ 0 πŸ“Œ 0
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Back in Argentina after the #KlebsiellaSymposium at @pasteur.fr. Grateful to the organizers @sylvainbrisse.bsky.social and @chcrestani.bsky.social for the opportunity to present my work on #Klebsiella in #Wastewater and to connect with brilliant researchers. Inspired and honored!

02.12.2024 18:39 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

often overlooked in EDI strategies and key to perceptions of excellence. Language coaching not the only solution (takes extra time too): need to normalise non-native accents/accept different ways of expressing oneself

25.11.2024 08:24 πŸ‘ 24 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0

From here #Klebsiella genomics really ramped up, and we now have >100,000 genomes in NCBI!
There’s too much to cover here, but we summarised some of it in this 2020 review pubmed.ncbi.nlm.nih.gov/32055025/ & will hear a lot of new stuff at #KLEBS week. Look our for a conference report!

20.11.2024 13:05 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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A small history lesson in #Klebsiella genomics in honour of #KLEBS24…
2009 was a big year for Klebs!
- First genome published
- First description of ST258 KPC-producing clone
pubmed.ncbi.nlm.nih.gov/19218573/
- First description of NDM-1 beta-lactamase
pubmed.ncbi.nlm.nih.gov/19770275/

20.11.2024 13:03 πŸ‘ 48 πŸ” 22 πŸ’¬ 3 πŸ“Œ 1

Let's increase #klebclub chatter on πŸ”΅πŸ¦‹!
Klebsiella aficionados add your handle below and we will build a starter pack.

πŸ” to spread the word

16.11.2024 19:35 πŸ‘ 18 πŸ” 14 πŸ’¬ 4 πŸ“Œ 1

Lots of people are missing, let us know if you want to be included by replying!
You can also share to help us gain visibility
#MicroSky

go.bsky.app/EdereoU

17.11.2024 13:49 πŸ‘ 25 πŸ” 19 πŸ’¬ 17 πŸ“Œ 2

Very much enjoying #Klebsiella2024 with great talks.

Some absolutely shocking data around AMR and mortality in neonatal infections in LMICs, which do not have access to new (and very few) drugs that still work.

20.11.2024 15:26 πŸ‘ 11 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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A genome-wide One Health study of Klebsiella pneumoniae in Norway reveals overlapping populations but few recent transmission events across reservoirs Members of the Klebsiella pneumoniae species complex (KpSC) are opportunistic pathogens that cause severe and difficult-to-treat infections. KpSC are common in non-human niches, but the clinical relev...

Interesting One Health study on Klebsiella pneumonie in Norway, which seems to confirm that there is little (but not no) spillover between human and non-human niches

www.biorxiv.org/content/10.1...

Presented by Marit Hetland #Klebsiella2024

21.11.2024 08:32 πŸ‘ 25 πŸ” 8 πŸ’¬ 1 πŸ“Œ 0