Osvaldo Chara

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Thrilled to share this adventure on how zebrafish elongates its notochord! 🐟 Kudos to Carlos Camacho de la Macorra and @bensteventon.bsky.social for leading it. Alberto Ceccarelli and I had so much fun modelling & uncovering unexpected predictions… A nice mix of maths 📐, computing 💻 & experiments 🔬!

Local control of cellular proliferation underlies neuromast regeneration in zebrafish - PubMed Biological systems are never in equilibrium, yet they maintain stability in the face of continuous external disturbances. A prime example of this is organ regeneration, during which organs are reliably rebuilt through controlled cellular proliferation. In this study, we employ a cell-based computati …

New publication from the lab! Very excited for a the new work in collaboration with Osvaldo Chara.

pubmed.ncbi.nlm.nih.gov/41617078/

How do living systems remain stable ? We found a local feedback that acts like a quorum-sensing system, ensuring organs regrow to the right size.

The article shows that regeneration of a key part of the sensory nervous system in zebrafish can be achieved by a mechanism compatible with local control. Please get in touch if you have any questions!
(9/9)

Comparison of the model simulations with experiments on regenerating neuromasts previously subjected to laser ablation suggests that our hypothetical proliferation switches are a robust mechanism of regeneration control.
(8/9)

This very simple mechanism is capable of isotropic regeneration after partial ablation in the mantle & sustentacular cells, consistent with experimental data.
(7/9)

Our results show that the tissue-wide regenerative response of the neuromast is consistent with a delayed proliferation switch modulated by the the number of neighbors.
(6/9)

We parameterized the CPM using our recent estimates of cell-cell interactions within the neuromast using our new method of Mechanical Stress Inference ForSys!
doi.org/10.1016/j.is...
Interestingly, these interactions allow the integrity of the organ to be maintained.
(5/9)

How do we get such an ordered structure after the chaos of laser ablation? We decided to investigate this problem quantitatively by using a Cellular Potts Model (CPM).
(4/9)

Neuromasts are known to have a remarkable regenerative capacity! Hernán's lab has previously shown that after laser ablation of up to 90% of a neuromast, sustentacular & mantle cells undergo an ordered proliferation-dependent regenerative response.
elifesciences.org/articles/30823
(3/9)

Firstly, and more importantly, this adventure involves the amazing Natalia Lavalle, @borgesaugust.bsky.social, Emanuel Cura Costa, in a fantastic collaboration with Jerónimo Miranda-Rodríguez and @hernanlopez-schier.bsky.social
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Curious about how to achieve organ-wide #regeneration through locally controlled cell proliferation? Check out our latest computational adventure addressing this problem in the #neuromast within the #zebrafish lateral line.
doi.org/10.1016/j.jt...
(1/9)

Woo hoo! Congratulations Giulia and totally well deserved. So proud!

Registration and submissions for poster presentations will remain open for a few more weeks: meetings.embo.org/event/26-hom...

OPPORTUNITY: McGill Plant Science is looking for an expert in plant pathology, plant breeding, or horticulture in the context of the Canada Impact+ Research Chairs Program (senior established researcher).
Contact: www.mcgill.ca/plant/contact
Program: lnkd.in/eavfNu7e

Please re-post.

Very interesting, congratulations!!

Amazing work!!! Congratulations!!!

Have a lovely family time during the holidays, Yanlan, see you in 2026!!

Registration deadline extended to 5th January. Festive greetings!

Throwback to Biologists @ 100: Interviews from Liverpool - the Node Earlier this year, The Company of Biologists celebrated its 100-year anniversary with the Biologists @ 100 conference in Liverpool - bringing together

During the #biologists100 conference, the Node's conference reporter @jens-cells.bsky.social spoke with Clare Benson, Luke Simpson and @m-stower.bsky.social. Here, each researcher tells us more about the work that they presented at the conference.👇

thenode.biologists.com/throwback-to...

Great quote
Waddington
Seen @DBT_inStem
#Embryo #CellsRUs #NotInTheGenes

Interested in doing an interdisciplinary PhD to elucidate signalling centres that orchestrates limb regeneration? Come to work with the amazing @canaztekin.bsky.social and myself!!

🚨We are recruiting two PhD students 🚨

1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions

Gradients, waves and nematics: quantitative perspectives on regeneration Regeneration restores a damaged body part to its original size, shape and structure. Research over the last decades identified signaling pathways, cel…

Tristan Guyomar and I wrote a review on physical mechanisms coordinating regeneration - Featured: signalling/mechanical gradients, travelling waves and nematic fields - Dramatis personae: axolotls, hydra, planaria, spiny mice and zebrafish (ofc) with a jellyfish cameo

tinyurl.com/3upzrdbs

Final week to register! #EMBOevents

A new research facility dedicated to axolotls, will be opening soon. Hosting the UK’s only dedicated axolotl research colony and will support world class studies into regeneration, ageing, cancer resistance and stem cell biology.

edin.ac/4pAAJeW

@edinuni-irr.bsky.social @aidarodrigo.bsky.social

Congratulations, Josh!! It seems super interesting!!

Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors Limb loss remains a significant clinical challenge, but regenerative medicine approaches such as gene therapy offer a promising strategy to trigger endogenous regeneration programs. Optimal vector con...

🚨 Preprint Friday! 🚨

Thrilled to highlight this collab with David Brown at Duke @cutitoutdave.bsky.social and Ken Poss at UW Madison/Morgridge @kenposs.bsky.social. By comparing 3(!!) regenerating models we identify a conserved role for Sp-family TFs in appendage regeneration (and more).....🧵

Are you a #devbio postdoc planning to go on the job market in 2026? Then this is the initiative for you! Offering training, networking, mentoring and profile-raising components, Development's PI Programme can give you that extra support you might need while navigating this challenging time...

Development's Pathway to Independence Programme Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:

Mentoring
Profile raising
Leadership training
Network building

Spread the word...

www.biologists.com/grants/devel...