Sri Kosuri

Carve up your own state and leave Jersey alone!

2025 was a year full of great scientific discoveries and breakthroughs. Here, I want to highlight 10 papers that got me really excited. Of course, this is a highly subjective selection and I am sure I am forgetting some papers that I would love to include, but here it goes: (1/12)

Learn the Science Behind the Tools, with Addgene and Promega logos and the Blugene mascot holding a light bulb

Tags, reporters, luciferase — oh my!
To celebrate the expansion of the Promega Plasmid Collection, we’re spotlighting some of our most popular blogs on the technologies researchers rely on every day — tools you can access through Addgene.

The elusive virtual cell Rosetta Stone or Moby Dick?

I wrote down some of my thoughts down on the current race to build virtual cell models. Overall, excited and wary about the work ahead. Also, it's my first post to Substack; getting more excited about it as a replacement for X and Blue Sky.

srikosuri.substack.com/p/the-elusiv...

Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program.

www.luxcapital.com/news/our-hel...

An update: After the diagnosis change to AML/myeloid sarcoma, we got a lot of great input. We’ve decided to go to St Jude’s to enroll in a clinical trial. We left for Memphis yesterday. We’ll be staying here for the next several months. Anxious but ready for the path ahead.

bsky.app/profile/srik...

We have a long road ahead of us, but the last week has made it much more clear on the diagnosis and what to do next. Thanks again for all the help. I feel like we have turned over every rock, we are getting great care and in touch with all the relevant folks. 🙏

Quick update: Thanks so much for the outpouring of support and help. We learned a lot in the last week and the tumor is actually a myeloid sarcoma likely derived from early AML, with the hope of possible targeted therapies as well (KMT2Ar).

I hadn’t seen this. Thank you.

People can contact me directly at my first name (as written in my profile) at octant.bio.

I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known.

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

a man in a kitchen with a sweater on that says oh no i am fine serenity now . ALT: a man in a kitchen with a sweater on that says oh no i am fine serenity now .

Serenity now

This is part of my effort of rewriting all materials for my UT Austin dataviz class in Quarto. It's going very well. Most importantly, I now have live exercises integrated into the site, thanks to Quarto live. Check it out here: wilkelab.org/SDS366/

Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social!

www.cell.com/cell/fulltex...

Noticed this last time I was there. Many a night at the Pig drinking golden monkeys and eating the curry fries.

Definitely beer.

A virally encoded tRNA neutralizes the PARIS antiviral defence system - Nature Structural and functional studies reveal how viral proteins trigger the phage antirestriction induced system (PARIS) to degrade host tRNA and how viral tRNAs suppress the PARIS nuclease and thereby ov...

Today's holiday ☕ reading is this 2024 paper on PARIS, a bacterial defense system shaped like a literal propeller that responds to viral infection by hitting the cellular self-destruct button - cleaving an essential tRNA. www.nature.com/articles/s41...

Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1 - Nature Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining e...

Really beautiful paper by @kjarmache.bsky.social revealing read-write mechanisms of histone ubiquitylation by Polycomb complexes - through an intricate interplay of ubiquitin binding and ubiquitin transfer. Congratulations to all authors!

www.nature.com/articles/s41...

Cover of the report - it's in a blue/purple color scheme and shows an abstract illustration of a molecule and the title of the report "Understanding and Addressing Misinformation About Science Consensus Study Report"

Out now - National Academies consensus report on Understanding and Addressing Misinformation About Science 🧪

It was a privilege to serve as one of the 15 committee members from a wide range of scientific disciplines who put this report together. Quick 🧵1/

www.nationalacademies.org/our-work/und...

Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...

In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization

Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation

www.biorxiv.org/content/10.1...

Specificity, length, and luck: How genes are prioritized by rare and common variant association studies Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...

What do GWAS and rare variant burden tests discover, and why?

Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?

Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)

www.biorxiv.org/content/10.1...

The responses to this are why change is not really going to happen within the universities themselves. I’m excited that AI has the possibility to break the cost curves to broad access to education. Lots of work to do, and thanks to those putting in that work to build a brighter future.

Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows The diffusion learning method, DiffDock, for docking small-molecule ligands into protein binding sites was recently introduced. Results included comparisons to more conventional docking approaches, wi...

I'm thrilled to announce a new preprint describing collaborative work with Ajay Jain and Ann Cleves Jain, "Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows".

arxiv.org/abs/2412.02889

Republicans See Attacking China As A Winning Strategy A new memo from the NRSC doubles down on the Trump campaign’s strategy of addressing coronavirus by attacking China and labeling Democrats soft on China.

Or that releasing strategy memos saying the best bet for political prospects is blaming China in march/april 2020 is not the best way to ask a country to hand over data. www.forbes.com/sites/andrew...

Wuhan lab samples hold no close relatives to virus behind COVID Shi Zhengli, the virologist at centre of COVID lab-leak theory, reveals coronavirus sequences from Wuhan institute.

"Wuhan lab samples hold no close relatives to virus behind COVID"

That should settle it, right? The problem, of course, it won't because we're dealing with conspiracy theories and not scientific inquiry - no amount of additional data will change un-evidenced beliefs.

www.nature.com/articles/d41...

That’s not all profit fwiw. For example, almost all heath care workers make significantly more in the US compared with these other countries. Would you be OK with Kaiser availability or other non-profit insurers to all? What advantage would single payer have over that?

Oh interesting. You can do it pretty easily.

Is there a way to do starter pack for people to block? Would love to just block folks en masse that are cheering on the execution of a company CEO b/c they hate capitalism or whatever. It's insufferable.