MeineckeLab

We had a great evening showing and discussing Picture a Scientist. It’s such an important topic, and we’re grateful for the big turnout, the lively discussion, and especially to Cristina (@cpaulino.bsky.social) and Alba (@diz-lab.bsky.social) for their thoughtful and engaging moderation!

Now @bzh-hd.bsky.social Jonathan Friedman is talking in #mitochondria organization

Tomorrow at the BZH:
We’re thrilled to host Jonathan Friedman (@labfriedman.bsky.social), who will present his latest research on mitochondrial biology.

📅 23.09.25 & 12:15
📍 BZH Heidelberg

Join us to explore fresh insights into how mitochondria shape cellular life!

Fantastic work guys, congratulations!!

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Thrilled to have contributed to this amazing work! Thanks for having us on board 🙌 Huge shoutout to our super-talented postdoc #MelanieKönig for her outstanding efforts 💫. And big congratulations to everyone involved in this terrific team effort! 🎉 @sfb1638.bsky.social @bzh-hd.bsky.social

📢 Tomorrow at the BZH: Don’t miss Chris Stefan from UCL presenting his latest research as part of our #SFB1638 Seminar Series! 🧬 A great chance to hear cutting-edge science and connect with the community. See you there!

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

Huge congratulations to Kerstin and Oliver and the entire team on your success in the Excellence Initiative! Well-deserved recognition and strong support for groundbreaking science ahead.

Great initiative by @uniheidelberg.bsky.social to promote collaborative efforts in life science! Enjoyed sharing insights on our Membrane SFB (Collaborative Research Center). Always a pleasure to discuss our work on membrane dynamics.

Just back from the Jacques Monod Conference on Membrane Remodeling in Roscoff—an inspiring trip for Sebastian Schuck and Michael Meinecke (@meineckelab)! We had exciting science, engaged in inspiring discussions, and enjoyed the stunning setting. There’s nothing quite like membrane research.

Biologie aus dem Baukasten Ingenieure, Informatiker, Chemiker und Biologen kreieren künstliche biologische Systeme. Die synthetische Biologie verändert die Zukunft und definiert die Grenzen der Wissenschaft neu.

Our SFB1638 PI Kerstin Göpfrich (@kgoepfrich.bsky.social) joined Gert #Scobel and Tobias Erb to explore the future of synthetic biology—its promise, challenges, and big ideas. Catch the super interesting discussion on @3sat (@3sat.bluesky.com.de)

www.3sat.de/wissen/scobe...

Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers The PRISM-MS workflow transforms single-cell mass spectrometry imaging by allowing detailed analysis of low-mass metabolites in large cell populations without metabolite degradation. By introducing n...

An exciting new approach in single-cell metabolomics from two SFB1638 groups! Carsten Hopf’s group from CeMOS with support from the Göpfrich lab (@kgoepfrich.bsky.social) unveil tech that tracks brain cell changes linked to neurodegeneration.

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Structural dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation The metabolism of ergosterol shapes this lipid to allow the formation of fluid membrane domains in yeast cells.

Out today, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains www.science.org/doi/10.1126/... (1/n)

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 Unconventional secretion of Fibroblast Growth Factor 2 (FGF2) is based upon direct self-translocation across the plasma membrane, a process that involves the transient formation of a lipidic membrane ...

🚨 Lipid Time! 🚨
Excited to share our latest story now on @biorxiv-biochem.bsky.social !
Our brilliant PhD student @manpreet0700.bsky.social , together with @walter-nickel-bzh.bsky.social and myself, shows how PI(4,5)P₂ asymmetry in the plasma membrane drives the unconventional secretion of FGF2!
👇👇👇

Static structures are out. A new publication from the Ellenberg lab ( @ellenberglab.bsky.social, @embl.org , @sfb1638.bsky.social ) and Andrej Sali shows how integrative spatiotemporal modeling captures molecular motion in 4D, unlocking dynamic views of nuclear pore complex assembly.

Lovely start into our new #SFB1638 on cellular membrane remodeling with a two-day kick-off meeting at the International Academic Forum Heidelberg (IWH). Many thanks to our speaker @meineckelab.bsky.social and team for the great organization.

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social