Katy

Hahaha well without you I might still be stabbing myself with the dissecting forceps and wondering whether mRNAs *really* need a 3'UTR 😂

Thank you Steven! Your identification of them as non-minute RP genes was one of the things that drew us to these genes, so that means a lot!

Thank you Cahir!!

Aaand... my first cover!!

RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬

Instead of finding evidence of #specializedribosomes, investigation of the RpS5b mutant phenotype revealed an unexpected response to ribosome insufficiency in the female germline 🪰

In the sole case where an RP paralogue was required for fertility, RpS5b, seamless replacement of the coding region with that of its paralogue RpS5a demonstrated that the two RpS5 proteins are functionally redundant.

Our systematic analysis of #Drosophila ribosomal protein paralogues didn't support a role in #specializedribosomes, despite frequent tissue-specific expression patterns, with the majority of paralogues being dispensible for both viability and fertility.

Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila

So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬

www.pnas.org/doi/10.1073/...

Inside each of us there are two wolves

Both of them are saying: "mate, those aren't resurrected direwolves, they're just modern wolves with a few gene tweaks and a ludicrous amount of hype."

Fall in overseas students fuels threat to English universities despite rise in fees Higher tuition costs have already been ‘wiped out’ by government tax hikes, critics claim

What about questioning the entire business model behind deliberately underfunding UK universities and making them depend financially on overseas tuition fees?

This is brilliant Peiwei, congratulations!!

The collective sigh and desperate hopes that maybe they'll keep on walking as 3 loud americans enter our train carriage...

Why is it that people that claim to follow the biopsychosocial model of pain often turn out focus entirely on the psycho 🙄

Some other helpful tips if anyone with #chronicpain is struggling:
"distract yourself" aye thanks I never would have thought of that on my own

Screenshot from "helpful website": Bold capitals: Have you been on pain medication for over 3 months? It's time to book a review with your GP. After 3-6 months your body would have healed or settled as much as it is going to. Taking medication for longer runs the risk of you becoming unintentionally addicted. Clickable button: How to book a review.

Screenshot from "helpful website", suggesting ways to manage your pain without medication: Remaining Positive. With a positive mindset it's easier to stay motivated and look ahead.

Screenshot from "helpful website", suggesting ways to manage your pain without medication: Mindfulness Techniques. Mindfulness encourages the acceptance of the pain and can calm your natural instinct to tense up.

Screenshot from "helpful website", suggesting ways to manage your pain without medication: Positive Imagery. Also known as visualisation, is a relaxation technique that aims to help lower the levels of stress hormones in your body.

Pharmacist sent me some "helpful links" for pain management after routine med review.

I've had chronic pain >10yrs, diagnosed with #fibromyalgia ~9yrs ago, and #hEDS #HSD this year.

No amount of positive thinking or fucking mindfulness is going to make my body produce collagen correctly 🤬

Email from Trainline saying "Get ready for Crewe"

Why does this sound like a threat?

This has reminded me of the most Middlewich headline ever, courtesy of the Middlewich Guardian a few years ago #salttown

Ribosome abundance, not paralogue composition, is essential for germline development Ribosomes catalyse all protein synthesis, and mutations altering their levels and function underlie many developmental diseases and cancer. Historically considered to be invariant machines, ribosomes ...

Thrilled to be able to share my PhD work with @FelipeKTeixeira @GeneticsCam
doi.org/10.1101/2024...
Give us a read if you're interested in #ribosome heterogeneity, #devbio, #translationalcontrol & #drosophila 🪰🔬

I refuse to join Bluesky - I don’t want to become part of an EcoRI chamber

Please could I be added!