Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude High-altitude conditions improve glucose tolerance and reduce diabetes risk, but the physiological mechanism is not well understood. Using mouse model…

Isha Jain at BARI just published this in Cell Metabolism: Living high up makes blood sugar drop because red blood cells soak up glucose in low oxygen. Hypoxia can even treat diabetes in mice! #metabolism www.sciencedirect.com/science/arti...

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration - Nature Reviews Drug Discovery Neuroimmune interactions shape neurodegenerative disease progression. This Review examines how microglia integrate signals from central and peripheral immune cells, outlines emerging therapeutic targe...

BARI’s Andrew Yang breaks down how immune cells in the brain fuel neurodegeneration and what we can target to stop it. From microglial states to complement and inflammasomes, this review maps therapies that could help aging brains stay sharp longer. go.nature.com/4096fGg
#aging #neuroscience

Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues - PubMed Molecular glues, compounds that bind cooperatively at protein-protein interfaces (PPIs), are revolutionizing chemical biology and drug discovery, allowing the modulation of traditional "undruggable" targets. Here, we focus on a native regulatory PPI between the scaffolding protein 14-3-3 and C-RAF, …

pubmed.ncbi.nlm.nih.gov/41617210/

BARI’s Andrew Yang unpacks how hypertension quietly injures the brain via AngII long before pressure rises. Early hits to endothelial cells, oligodendrocyte precursors, and inhibitor neurons, all independent of blood pressure. Strong implications for better dementia prevention strategies.

Exploring the Association between Epigenetic Age and Intensive Care Unit Delirium: A Pilot Feasibility Study Abstract. Epigenetic clocks (EC) measuring epigenetic age (EA) and epigenetic age acceleration (EAA) are biomarkers of biological aging, but their associat

John Newman at BARI looks at ICU delirium and epigenetic clocks: Feasible from serum, with Elastic Net acceleration linked to lower severity scores (day 8 and at discharge). A noteworthy finding on biological aging in acute illness. academic.oup.com/biomedgeront...

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

BARI spotlight: Dr. Martin Kampmann leads Cell study using CRISPR in iPSC neurons to decode tau handling, spotting ways to block toxic buildup in age-related diseases like Alzheimer’s. Read the article here: www.cell.com/cell/fulltex...

Ageing promotes microglial accumulation of slow-degrading synaptic proteins - PubMed Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates with ageing^1,2. Here we engineered bioorthogonal tools³ that enabled us to tag the …

This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging

Fibroblast Modulation of Stem Cell Lineage Infidelity and Metaplasia in Tissue Fibrosis - PubMed Epithelial stem cells are segregated on the basis of region-specific identities during homeostasis. However, tissue perturbations can induce remarkable plasticity in stem cells to adopt lineage identities outside their anatomical compartments. This phenomenon has been termed lineage infidelity or me …

Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/

Genetic and Carcinogenic Risks of Radiotherapy for Nonmalignant Diseases Radiotherapy is a valuable treatment option for a variety of nonmalignant diseases. As the indications for low-dose radiotherapy to benign conditions …

Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygou…

Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate - Nature Communications Pcm1 bridges centrosome asymmetry and polarized endosome trafficking to regulate radial glia progenitor fate decisions, balancing self-renewal and differentiation in zebrafish and human cortical organ...

Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience

Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):

grants.nih.gov/faqs#/common...

Past, present and future perspectives on the science of aging - Nature Aging As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related diseas...

Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science

Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).

Tissue Repair Slows in Old Age. These Proteins Speed It Back Up UCSF scientists engineered old fibroblast cells to turn their genes on and off in the same way as young fibroblasts. The old fibroblasts were rejuvenated: they multiplied (green) and produced more of ...

UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...

Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis Cartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression of osteocytic perilacu...

Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...

Is there coordinated push back against the MYF provision in the FY 2026 bill? Who are we supposed to call? Email?

What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch

What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.

Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.

Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience

Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience

BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.

Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4

Jarin Tusnim – Cure Alzheimer's Fund Dr. Jarin Tusnim is a postdoctoral scholar in the Department of Pediatrics at the University of California, San Francisco (UCSF). She received her B.Sc.

Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q

Exciting work! Can't wait to read it!!

So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience

Excited to continue to push the field forward with so many talented scientists and clinicians! Way to go UCSF🎉!

Excited to collaborate with @fusionconf.bsky.social again to highlight the most exciting advances in #Stemcell biology🧫🔬! Great opportunity for early career researchers to share their data and network with leaders in the field. Join us in Mexico🌴😎

Ummmm.... what's the name of this gem??