We made FLIP2, a protein fitness benchmark spanning seven new datasets, including enzymes, protein-protein interactions, and light-sensitive proteins, as well as splits that measure generalization relevant to real-world protein engineering campaigns.
The Logic of Catastrophe open.substack.com/pub/clairebe... Nuclear war isn't inevitable, but if we don't mitigate these risks, it approaches it. None of them will be fixed by optimism, fatalism, or denial. It will only be fixed if citizens get serious about this.
We used to think that the benefit of GLP-1 drugs (like Ozempic) was dependent on weight loss.
Now we know so many health benefits have little to do with that!
Today's report: www.sciencedirect.com/science/arti...
Opportunity in chemical development at AstraZeneca (Dublin Ireland) closing: 27-Jan-2026 #SynChem #EUChemJobs #ChemJobs #chemsky 🧪
astrazeneca.eightfold.ai/careers/job/...
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
@ppfideas.bsky.social come do some live events in New York this year. We’d love to see you in person
Oxide is hiring in the embedded space. If you enjoy baffling choices by hardware vendors and debugging performance issues come join me.
oxide.computer/careers/sw-e...
Loved this pair of episodes. I was laughing at Chis’ unexpected jumps into accent.
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
BoltzGen now published and available as MIT licensed software
Quarto friends! I need your help:
We are implementing a new QMD parser in Quarto. It will be super nice. But it's a big change, and we want to minimize the impact.
1. Can you share a link to your Quarto project at github.com/quarto-dev/q...
2. repost this and let your Quarto friends know too?
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
This is a cartogram depicting the share of land associated with various purposes in the United States. From https://www.bloomberg.com/graphics/2018-us-land-use/#xj4y7vzkg
Below is a clever visualization of the distribution of how land is used in the US. Cows roam over a lot of land!
But this is not a map - for example, the 100 largest landowning families aren't confined to Florida.
What if the Moon were made entirely of electrons?
Watch the latest What If? video collaboration with @minuteearth.bsky.social!
youtu.be/DiWFXv9N0Vs
Looking forward to discussing INDIGNITY with David Runciman @ppfideas.bsky.social at @waterstones.bsky.social in Cambridge THIS Wednesday! And I hope to see many of you there 🤩😍!
For tickets: t.co/WY5iWDIUZ1
Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)
The Mask of Sorrow is a monument located on a hill above Magadan, Russia, commemorating the many prisoners who suffered and died in the Gulag prison camps in the Kolyma region of the Soviet Union during the 1930s, 1940s, and 1950s.
The anti-inflammatory power of semaglutide (Ozempic) seen by its normalization to healthy of a 72 protein signature tied to MASH liver disease
nature.com/articles/s41...
Software history nerds don't miss Casey Muratori's long-ass talk tracing the origins of OOP
www.youtube.com/clip/Ugkx9Di...
🔓Read a #OpenAccess review by @drlaurasanchez.bsky.social et al. from @ucsantacruz.bsky.social in our MS Metabolomics themed collection covering mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes #secmet #natprod
ggplot2 4.0.0 is coming soon, and is moving some of the internals from S3 to the new S7 OOP system. This is worth a read if you're developing packages with ggplot2 (bioconductor or otherwise) blog.bioconductor.org/posts/2025-0... #Rstats
Beautiful. I really like the speed changes as emphasis
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
A graphical summary of the method.
In today's featured article, Kerackian, Romero-Laboureur et al. use high-throughput experimentation to construct a high-quality dataset on nitration reactions and use it to develop a predictive machine learning tool. Find out more in this open access Communication: doi.org/10.1039/D5DD...
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
Journalists keep asking me, baffled, “What’s the Trump administration really trying to do to the science agencies?”
So I say “They are trying to destroy them. Cut off their funding, ruin their facilities, harass their staff into leaving.”
It’s not reform, and it never was. It’s destruction.
A new paper reports the genomic discovery and biochemical characterization of a widely distributed gene cluster family for briarane diterpenoid biosynthesis in metazoans
www.nature.com/articles/s41...
On the left, a picture of a Petri dish showing an amycalotopsis from which comes in the center, a cartoon dragon and under the dragon the molecules called Dracomycins, which are drawn in the shape of the dragon. On the right a petri dish showing a cartoon of zones of inhibition.
Dracomicins, Hybrid Oligosaccharide–Nonribosomal Peptide Antibiotics from Amycolatopsis Species
pubs.acs.org/doi/10.1021/...
