Happy to see this amazing work finally out. We used our NePSTA model to acurately predict the epigenetic subtypes of meningiomas based on cell-type abundance in subgraphs containing gene expression features + spatial adjacency.
Can immunotherapy ever work in #glioblastoma?
In a new #NatureCancer review, we share our perspective on current limitations and future directions:
www.nature.com/articles/s43...
#NORLUX, #LIH , @fnr.lu #TELEVIE, @glioresolve.bsky.social, @michael-platten.bsky.social
Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1...
#immunotherapy, #preclinicalmodeling,
Amazing Keynote talk by @heilandhenrik.bsky.social on "Translational Data Integration and Technological Developments in Neuro-Oncology" at the ongoing #SNO2025 in Hawaii.🧠
Be sure to check the @milolab.bsky.social talks including our work on "Deciphering spatiotemporal trajectories of tissue adaptation after surgical resection of glioblastoma."
#EANO2025 was awesome. Great time interacting with mentors and colleagues. Looking forward to another exciting meeting.
Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together!
📢 @eanoassociation.bsky.social 2025 kicks off today in Prague!
Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning.
More info 👉 www.eortc.org/blog/2025/10...
#EANO2025 #NeuroOncology @qol.eortc.org
Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
Thanks Roman.
Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...
#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Two massive glioblastoma papers, datasets, trajectories, insights, and.. a very cool new method for GRN inference - scDORI -from @steglelab.bsky.social @oliverstegle.bsky.social @bayraktarlab.bsky.social & Moritz Mall www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉
Putting cancer immunotherapy into spatial context in the clinic - @joakimlundeberg.bsky.social @scilifelab.se @ki.se go.nature.com/4jlus4b
The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq
Congratulations to Annette. Well deserved.
📣 Open computational PhD & Postdoc positions!
Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus
📢 Please RT (what's the bsky equivalent here?) and distribute !
👇A quick instruction on how to apply
Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas
https://go.nature.com/434f4ns
🎗️ Today is #WorldCancerDay – a reminder of the ongoing fight against cancer and the need for research, collaboration & innovation in all types, including #NeuroOncology. At #EANO, we’re dedicated to advancing science and patient care. Together, we can make a difference! 💙
Beautiful work from @tobiw2024.bsky.social and @rsankowski.bsky.social
Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics
🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs
t.co/GmA9MLNKy1
Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!
www.instagram.com/the_milolab/...
Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
Happy to be part of this beautiful work from @milolab.bsky.social and Sahm lab.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.
New insights on #machineLearning #glioblastoma and other brain #tumors by the Heiland and Sahm labs
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social
www.nature.com/articles/s43...
