Mike Barnkob

🙁

LNP/mRNA methods are interesting outside vaccines in the context of cancer therapies. For example to deliver CAR therapy. Much of this work is very heavily leaning on work from the vaccine field, and shutting down this research has huge implications here (as well).

Unless you’re gunning for a 1.6 million grant, I don’t think a lot of Danish doctors feel that way.

It's the 3rd of January 1939, your name is professor James Smith and you are staring at a drawing of a fish. It's not a regular fish. It is a completely impossible fish.

But the rapport is not from the Danish authorities: it's written as part of a research-training course doctor take during their speciality training as general practitioners.

Note the front page says: "Research training assignment 2018" and "Group 38".

I am not sure the presentation by Tracy Høeg necessarily reflect the true situation in Denmark.

For example, her discussion about varicella zoster vaccine highlights a rapport written by non-experts, and present it as if, it is from the Danish authorities.

It’s definitely true that preexisting immunity affects transmissibility; but I think the virus adapted for increased transmission in humans as well, eg the D614G mutation and increased binding to ACE receptor found in some variants. Really I think you to look at protein level, not the variant name

In Denmark they are still offered in 2 and 3 trimester as fare as I can read

BAFF-R and CD21 dysregulation inhibits memory B cell persistence in patients with common variable immunodeficiency Background Individuals with common variable immunodeficiency (CVID) are at increased risk of respiratory infections such as SARS-CoV-2 infection due to poorly understood defects within the memory B ce...

Patients with CVID are at increased risk following infection with virus, due to poor B cell function.

The pandemic allowed us to examine how CVID patients reacted to a novel antigen.

Here we characterized B cell function. across multiple immunization events.

www.medrxiv.org/content/10.1...

Question is whether previous infections / vaccinations decreases this risk today. I am not saying I would risk it, but I am not sure the risk today is the same as in 2022 as most people have had multiple immunization events at this point

Wait what, so the universe a gigantic cell or what is going on here?

Skin damage signals mediate allergic sensitization to spatially unlinked antigen Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.

#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!

Thanks - and thanks for all the work you put into these posts 😀

The recombinant shingles vaccine is associated with lower risk of dementia - Nature Medicine A natural experiment including more than 200,000 people who received a shingles vaccine reveals that, within 6 years of vaccination, the recombinant vaccine is associated with lower risk of dementia t...

Here’s a nice study looking at that exactly: www.nature.com/articles/s41....

The recombinant shingles vaccine is associated with lower risk of dementia - Nature Medicine A natural experiment including more than 200,000 people who received a shingles vaccine reveals that, within 6 years of vaccination, the recombinant vaccine is associated with lower risk of dementia t...

It does indeed look like Shingrix have a similar effect: www.nature.com/articles/s41...

Herpes Zoster Vaccination in SLE: A pilot study of Immunogenicity Patients with systemic lupus erythematosus (SLE) are at increased risk of herpes zoster (HZ). Although a vaccine for HZ has been FDA approved, its use in immunocompromised individuals remains controve...

Additionally, certain types of autoimmunity also seem to react less strongely to the Zostavax vaccine. E.g. SLE patients generate a lesser T cell response (pmc.ncbi.nlm.nih.gov/articles/PMC...). But really there does not seem to be much data around on this? 3/3

How certain are you that this is actually the case? I am asking because many autoimmune patients are presumably taking drugs that affect a vaccine-response negatively (B-celle depleting drugs, DMARDS, ect). Also, I assume many autoimmune patients are not allowed to use live-vaccines? 2/3

Congratulations on a very interesting and important paper. In your discussion concerning the mechanism, you examine VZV-independent effects. You have a section on autoimmunity, which sort of hinges on whether the vaccine elicits the same response in autoimmune patients as healthy individuals. 1/3

The clinical landscape of CAR NK cells - Experimental Hematology & Oncology Chimeric antigen receptor (CAR) NK cell therapy has emerged as a promising alternative to CAR T cell therapy, offering significant advantages in terms of safety and versatility. Here we explore the cu...

CAR NK cells are being explored as an off-the-shelf cell-therapy. How and against what are they being tested?

Lasse and Emil from our group did a fantastic deep dive into all clinical trials being conducted using CAR NKs. Check out our review: link.springer.com/article/10.1... #CAR #NK #Immunology

If we’re in the range of say 10.000 other solar systems - and they need to spend a few million year evolving into something that cares / is able to look/send signals, perhaps the numbers don’t stack up so high as Fermi predicted? 2/2

If we imagine other species have the same tech we currently have: how many solar-systems could realistically have spotted us or received radio-waves from earth? I guess my point is, isn’t the period in which we have made noise/generated a bio-signatur too small for that many systems to spot us? 1/2

Assessing CAR T cells cytotoxic capacity at the single-cell level can be tricky.

Here we provide a method for encapsulating >500.000 single CAR T cells with single target cells in droplets together with reagents to examine killing using standard flow cytometry:

app.jove.com/t/67657/drop...

Wup wup!

Fresh Asteroid, Getcher Fresh Asteroid Here

A detailed look at fresh samples taken from asteroid Bennu confirms that organic chemistry (and the molecules of life) are everywhere:

Thank you for writing this

Jeg tror mere min tanke er: nu er jeg jo lige sluppet af med en dårlig vane, så måske lige vent lidt inden man hopper i igen på en anden app

You must have picked the two scientific fields with the most elaborate nomenclature ever 😅

*Laughs in immunology*: you guys have it too easy, try coming up with new sub-celltype names every month or so. Who would have thought the immune system needed 100 different T cell types, but here we are

Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models - Nature Communications Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between ...

Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...

It IS a fantastic book! Happy new year 🎉🥳