The Coster lab 🧬🔬

Thanks Chiara! Great to hear 😊

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Read our latest work - a comprehensive review on how DNA secondary structures affect replication.

Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.

Open Access in DNA Repair:
doi.org/10.1016/j.dn...

Typos in the genome: Defining the molecular mechanism of replication slippage Typos in the genome: Defining the molecular mechanism of replication slippage

📢 Last days to apply! 📢

Fully funded PhD position, starting Oct 2026.

Deadline Nov 16th.

We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.

Project details: tinyurl.com/CosterPhD

Apply: tinyurl.com/ApplyICR

The lab: CosterLab.com

Typos in the genome: Defining the molecular mechanism of replication slippage Typos in the genome: Defining the molecular mechanism of replication slippage

🧪📣 PhD studentship available! Please repost.

Our lab has a fully funded PhD position, starting Oct 2026.

We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.

Project details: tinyurl.com/CosterPhD

How to apply: tinyurl.com/ApplyICR

Congrats Alexis! Fantastic news and well deserved 🎉

Some repeats and structure-forming sequences are indeed difficult to clone, not because they are toxic, but because they are genetically unstable. Examples are AT and CGG repeats. If a sequence is problematic, cloning efficiency will be low, but clones you do get will have deletions in that area.

Are you having issues with a plasmid or are you trying to introduce a toxic sequence on purpose?

🎉 Congrats Mathew and Mike! Great to finally see this out. A fantastic tool for the replication community and beyond 👏

Congrats Hasan. Well deserved 🎉😁

Very cool to see MCM loading in action and with such detail. Years of genetic, biochemical and structural work from many labs distilled into a beautiful animation 🧬👍

Had a fun day in the sun, hosting the lab for a BBQ
🍔🥗🍺☀️
Great food and company 😁
I am so grateful and happy to work with such lovely people 😎

Congrats Stephen 🎉🎉🎉

Congrats Puck and Koichi 🎉 Super exciting G4 biology 🧬

New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷

Welcome to our newest lab member - Ellie Wright.
She did her PhD with Matt Neale and will lead data analysis and omics in the lab as a Higher Scientific Officer 💻🧬

🚨 We’re hiring ! 🚨
Join our cutting-edge research team as a molecular biologist at @nanoporetech.com HQ in Oxford.
Perfect for a fresh PhD or MSc with a couple of years’ experience. Work at the interface of chemistry, molecular/synthetic biology and AI

👉 ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...

Congrats Tanmay 🎉🎉

Great to have two lab alumni visit - Manolo @dazamartinlab.bsky.social and Sophie. Congrats to Manolo's son Javier on his first birthday 🎂🎊

📷 New lab photos 😎
Still undecided as to which one is better... But we all look so happy 😏

Had a fantastic day at the Genome Damage and Stability Center in Sussex. Lovely to see Brighton and have stimulating discussions with colleagues. Thanks Laurence Pearl for the invitation!

Congrats Dirk and team! Great work and good to finally see it out!

🎉🔬 The lab has expanded! Today we celebrated the joining of Adi and Maria, two postdocs, with great Vietnamese food 🍽️

Congrats Alessandro!

Thanks Francesca!

Thanks Christian!

Thanks Alessandro!

Thanks Annabel!

Thanks Martijn!

Thanks Colin!

Thanks Aga!