www.jclinepi.com/article/S089...

Top. On remet le vaccin zona à plus tard et on mets les 6 milliards d'euros prévus pour d'autres priorités...

Representation and outcomes of individuals with major depression in routine care who are ineligible for randomized controlled trials: a nationwide register‐based study Randomized controlled trials (RCTs) are the foundation of current clinical treatment guidelines. However, they may not reflect real-world populations, due to strict eligibility criteria. We determine...

About 1/3 of patients would be excluded from clinical trials. However, instead of calling for "real-world" data to complement RCTs, shouldn't we have more real-world (pragmatic) RCTs?
And the way keep up defending antidepressants, well...

Oui, pour tous les essais concluants seulement par des critères sensible au bias d'absence d'insu...(hospitalisations, décisions, revascularisation...mais aussi attribution d'une cause à la mortalité) et surtout si l'index de fragilité est faible...

Si on abandonne UKPDS (33 aussi), alors il n'y a plus de cible d'Hba1c à atteindre car c'est la seule dans le DT2 qui est considérée (à tort) comme probantes...

FDA drugs and biologics guidance for Bayesian clinical trials is something I've been dreaming of for decades. I am thrilled that this draft has been released!! #Statistics #StatsSky #fda #clinicaltrial #bayes

www.cnge.fr/wp-content/u...

La fin de la metformine en première intention approche...
Cela illustre parfaitement le problème que je mets souvent en avant : qu'est ce qu'une evidence dans l'EBM???

Je vous l'envoie par mail...en privé.
Merci de me donner votre mail...

:-)

www.jle.com/fr/revues/me...

Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis Objective To provide up-to-date evidence on key benefits, harms, and uncertainties regarding medications for adults with type 2 diabetes. Design Living systematic review and network meta-analysis (NM...

Je ne sais pas si bigpharma a un rôle ici...
Pour les données actuelles :
www.bmj.com/content/390/...

Ce qui est étonnant, c'est la lenteur des changements de pratique et des recommandations...
Un jour on dira " on le sait depuis longtemps..."
Et quand je l'ai écrit avec JP Boissel, on me disait "tu te trompes"...(surtout Prescrire "-))

How to survive the medical misinformation mess Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, mi.....

Je conseille cet article
onlinelibrary.wiley.com/doi/10.1111/...

Je le dis depuis 2009...
www.jle.com/fr/revues/me...
Qu'en pense @vmontori.bsky.social

Fluoxetine Versus Placebo in Preventing Relapse of Major Depression in Children and Adolescents The authors compared fluoxetine and placebo in continuation treatment to prevent relapse of major depressive disorder in children and adolescents. After a detailed evaluation, children and adolescents 7–18 years of age with major depressive disorder ...

Hello
What do you think about that?
pmc.ncbi.nlm.nih.gov/articles/PMC...

No names, unfortunately 😉
bmjopen.bmj.com/content/15/1...

FLX was not superior to PBO.....

Restoring TADS: RIAT reanalysis of the Treatment for Adolescents with Depression Study - PubMed BackgroundThe Treatment for Adolescents with Depression Study (TADS) continues to influence international clinical practice guidelines for adolescent depression.ObjectiveWe assessed TADS' effectiveness and harms through a Restoring Invisible and Abandoned Trials (RIAT)-led reanalysis.MethodsTADS was …

pubmed.ncbi.nlm.nih.gov/40421808/

#Ibuprofene #Ketoprofene #Naproxene #Diclofenac #Douleur #Entorses #LesionsMusculaires #SystemeMusculosquelettique

Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires

Bon usage du médicament

Évaluation de la qualité des preuves citées dans les guides de pratique clinique français d’infectiologie en soins primaires

#Recommandations #Antibiotiques #SoinsPrimaires
www.em-consulte.com/article/1773...

Calcium score: what do the most reliable guidelines recommend? An analysis using the G-TRUST tool AbstractIntroduction. In 2023, cardiovascular disease was the leading cause of death worldwide. Various risk calculation tools based on risk factors can be

academic.oup.com/fampra/artic...

Clinical prudence urged in testing for steatotic liver disease We read with interest “[Approach to steatotic liver disease in the office. Diagnosis, management, and proposed nomenclature][1]” by Szilagyi and Hilzenrat in the April 2025 issue of Canadian Family Ph...

Voilà un raisonnement fondé sur les preuves....et une perspective de médecine générale !
Bravo!
www.cfp.ca/content/71/1...

@deprescribing.bsky.social @deprescribeus.bsky.social @reeve-research.bsky.social @trudypharmd.bsky.social @frankmoriarty.bsky.social @caden-recad.bsky.social @dremilymcd.bsky.social @doctorsofbc.bsky.social @bcfamilydocs.bsky.social @bcpharmd.bsky.social

Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial - Child and Adolescent Psychiatry and Mental Health Background/Objectives Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors. This study aimed to assess freque...

"About 67% of all antidepressant and antipsychotic treatment episodes in the 700 included patients (mean age = 14.6 years, girls = 67%) were off-label."
link.springer.com/article/10.1...

@ioanaacristea.bsky.social
@ploederl.bsky.social
@floriannaudet.bsky.social
No difference between fluoxetine and placebo in a powerful double-blind trial.
Combo effect linked to lack of insu?

Restoring TADS: RIAT reanalysis of the Treatment for Adolescents with Depression Study - Natalie Aboustate, Jon Jureidini, Richard Woodman, Joanna Le Noury, Julie Klau, Elia Abi-Jaoude, Melissa Raven,... Background The Treatment for Adolescents with Depression Study (TADS) continues to influence international clinical practice guidelines for adolescent depressio...

journals.sagepub.com/doi/10.1177/...

REB: meta analysis of low-risk-of-bias trials and consideration of the confirmatory nature of trials

opportunity costs associated with NICE recommendations.

Defo the most important h economics paper you will read today, maybe this week, maybe the year so far

This is where the primary care budget gets spent

A

www.thelancet.com/journals/lan...