Sophie de Carné (she/her)'s Avatar

Sophie de Carné (she/her)

@sdecarne

Cancer Biologist • Junior Professor and Group Leader at Gustave Roussy • Franco-British Young Leader 2025 🇨🇵🇬🇧 @univparissaclay.bsky.social @gustaveroussy.fr @crick.ac.uk

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Latest posts by Sophie de Carné (she/her) @sdecarne

Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...

03.02.2026 21:27 👍 150 🔁 41 💬 0 📌 1

Cytokines are tricky to study, let alone in vivo. New tool to study cells that respond to cytokine receptor activation

08.01.2026 08:43 👍 11 🔁 2 💬 0 📌 0

Beautiful work and beautiful images.

05.01.2026 11:11 👍 1 🔁 0 💬 0 📌 0
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Somatic evolution following cancer treatment in normal tissue - Nature High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Nature research paper: Somatic evolution following cancer treatment in normal tissue

go.nature.com/48MhLvf

12.12.2025 15:00 👍 12 🔁 5 💬 0 📌 0

And we do not yet know what the impact will be on the rest of their lives.

08.12.2025 20:19 👍 1 🔁 0 💬 0 📌 0

If you are interested in how oncogenic RAS signalling influences the immune landscape of lung adenocarcinoma, our latest preprint on the subject is out on @biorxiv-cancer.bsky.social

#KRAS #lung #immuno-oncology #preprint 🧪

04.12.2025 17:26 👍 5 🔁 2 💬 0 📌 0
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Paul Nurse describing the main job of a PI

(From ‘The Thinking Game’, 2024)

31.10.2025 08:45 👍 181 🔁 53 💬 2 📌 5
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...

Cell plasticity as a mechanism to evade KRAS inhibition in colorectal cancer.

#KRAS #CellPlasticity #CancerStemCell 🧪

29.10.2025 06:48 👍 8 🔁 1 💬 1 📌 0

Bravo 👏

22.10.2025 12:41 👍 1 🔁 0 💬 0 📌 0
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#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine

Translational work showing mechanism of increased INF-alpha leading to immune priming

Phase III in development… @oncoalert.bsky.social

19.10.2025 13:22 👍 3 🔁 3 💬 0 📌 0
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Quels progrès dans la lutte contre le cancer ? (2/2) - L'Humanité Les pathologies cancéreuses sont mieux combattues. Les récentes découvertes liées à l’immunothérapie viennent s’ajouter aux thérapies ciblées et géniques. Mais des questions se...

📰 « Quels progrès dans la lutte contre le cancer ? »

@humanite.fr publie la tribune du Pr Fabrice André qui appelle à renforcer la prévention et la recherche sur les causes environnementales et comportementales des cancers, chez les 20-40 ans.↩️

www.humanite.fr/en-debat/can...

16.10.2025 09:31 👍 1 🔁 1 💬 0 📌 0

Yet another example of negative commercial determinants of health

Sunbeds are known to be especially harmful for young population, increasing the risk of skin cancer by 59%, according to the cancer research agency

And again yet, some governemnts prioritise (commercial) profir over (public) health

02.10.2025 08:03 👍 2 🔁 1 💬 0 📌 0

If you are looking for a postdoc position in a great lab with a fantastic PI, the Caswell Lab at UCL is recruiting 🙂

25.09.2025 16:32 👍 4 🔁 2 💬 0 📌 0
This is figure 5 from Wildfire smoke exposure and mortality burden in the US under climate change. It shows the mortality impacts of wildfire smoke PM2.5 and estimated mortality due to smoke 533 PM2.5 under future climate scenarios.

This is figure 5 from Wildfire smoke exposure and mortality burden in the US under climate change. It shows the mortality impacts of wildfire smoke PM2.5 and estimated mortality due to smoke 533 PM2.5 under future climate scenarios.

Increases in wildfires are expected to cause a notable increase in premature deaths, according to two studies in Nature.

go.nature.com/4mynauQ
go.nature.com/4nJoxI5
#medsky ⚒️ 🧪

19.09.2025 19:49 👍 19 🔁 10 💬 1 📌 0

Debbie, you cumulate successes! Congratulations. This is amazing.

19.09.2025 07:28 👍 1 🔁 0 💬 1 📌 0

Très astucieux. Bravo !

19.09.2025 07:27 👍 1 🔁 0 💬 0 📌 0
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Gustave Roussy toujours 1er centre français et 1er centre européen en oncologie L’excellence de Gustave Roussy est une nouvelle fois reconnue par le magazine américain Newsweek, qui a classé l’Institut 1er centre de lutte contre le cancer en France et en Europe, et parmi les meil...

📰 @gustaveroussy.fr toujours 1er centre français et 1er centre européen en #oncologie.

En savoir plus ⤵

15.09.2025 13:21 👍 2 🔁 2 💬 0 📌 0

Congrats Emma! Well deserved.

10.09.2025 10:41 👍 0 🔁 0 💬 0 📌 0
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📰 La chercheuse Sophie de Carné nommée Young Leader par le Conseil franco-britannique.

29.08.2025 10:29 👍 3 🔁 1 💬 2 📌 0

Congrats @inigolanda.bsky.social and Stephanie Corgnac 👏

27.08.2025 08:27 👍 5 🔁 1 💬 1 📌 0

📌 great thread.

24.08.2025 12:15 👍 1 🔁 0 💬 1 📌 0
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Lung Cancer Prevention Laboratory Pioneering research in lung cancer to improve diagnosis, treatment and prevention

I am excited to announce that my laboratory @ucl.ac.uk is now open!

We are hiring so please contact us if you are interested.

www.caswelllaboratory.com

07.04.2025 19:34 👍 17 🔁 8 💬 4 📌 0

Very nice. Where is it?

15.08.2025 06:04 👍 0 🔁 0 💬 0 📌 0
The Past, Present and Future of Immunology Research – with Caetano Reis e Sousa
The Past, Present and Future of Immunology Research – with Caetano Reis e Sousa YouTube video by Francis Crick Institute

Join Caetano Reis e Sousa (@reisesousalab.bsky.social) as he describes how our immune systems work and his team’s research into better understanding dendritic cell receptors. www.youtube.com/watch?v=nBC9...

16.07.2025 16:16 👍 10 🔁 3 💬 0 📌 0

I agree, Larry. I use it to get an overview of something I am not familiar with. I brainstorm with it. I ask for “brutally honest feedback” with a prompt that makes it challenge my thinking.
But I would not make it generate text from scratch. I have tried and it isn’t helpful.

22.07.2025 15:47 👍 1 🔁 0 💬 0 📌 0
Writing is thinking - Nature Reviews Bioengineering On the value of human-generated scientific writing in the age of large-language models.

Writing is thinking. A reminder on why scientists write, and why we should continue writing in the era of large-language models by Nature Review Bioengineering

@natureportfolio.nature.com
www.nature.com/articles/s44...
#AI #LLM 🧪

22.07.2025 08:07 👍 32 🔁 7 💬 1 📌 0

Depends… Does it have a bottle opener? 😅

18.07.2025 21:46 👍 1 🔁 0 💬 1 📌 0
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How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...

31.01.2025 14:29 👍 244 🔁 47 💬 6 📌 2

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

06.06.2025 15:32 👍 40 🔁 12 💬 5 📌 0

Very important and timely statement from @miriammerad.bsky.social, president of IUIS.

03.07.2025 09:07 👍 5 🔁 1 💬 0 📌 0