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Struan Grant

@struangrant

Professor of Genetics and Pediatrics, UPenn/CHOP🧬. https://orcid.org/0000-0003-2025-5302. Views my own. πŸ΄σ §σ ’σ ³σ £σ ΄σ ΏπŸ‡ΊπŸ‡Έ

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13.12.2023
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Latest posts by Struan Grant @struangrant

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Research Postdoctoral Fellow - Grant & Sengupta Labs in Philadelphia, Pennsylvania, United States of America | Fellows, Students & Interns at Children’s Hospital of Philadelphia Apply for Research Postdoctoral Fellow - Grant & Sengupta Labs job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Fellows, Students & Interns at Chil...

My lab is seeking to co-hire another postdoctoral fellow with the @shaonsengupta.bsky.social team. See details below!

careers.chop.edu/us/en/job/10...

25.02.2026 17:39 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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14.02.2026 17:47 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Re-posting given recent adds
go.bsky.app/9asWtuD

15.12.2024 15:01 πŸ‘ 72 πŸ” 16 πŸ’¬ 1 πŸ“Œ 2
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A true honor speaking at the 'Festschrift' for my PhD supervisor from many years back. Best wishes to Stuart Ralston!

29.01.2026 18:31 πŸ‘ 4 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes - Nature Genetics Nature Genetics - Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

20 years ago today we first reported the TCF7L2 association with type 2 diabetes @natgenet.nature.com. Much to still figure out for this locus....

www.nature.com/articles/ng1...

15.01.2026 12:34 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

@atothezphd.bsky.social
@alessandrachesi.bsky.social

13.01.2026 13:04 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Delighted to contribute to this work led by Kyla Mace and @kayserlab.bsky.social: "Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2". @penngenetics.bsky.social @chopresearch.bsky.social

www.nature.com/articles/s41...

13.01.2026 12:56 πŸ‘ 4 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk npj Dementia - Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk

Delighted to contribute. "Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk".
@alessandrachesi.bsky.social @lisanwang.bsky.social

rdcu.be/eXOb5

06.01.2026 12:52 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Annual Report: CHOP Scientists' 2025 Highlights with Struan Grant, PhD
Annual Report: CHOP Scientists' 2025 Highlights with Struan Grant, PhD YouTube video by CHOP Research Institute

www.youtube.com/watch?v=XGvE...

02.01.2026 19:43 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Annual Report: CHOP Scientists' 2025 Highlights with Struan Grant, PhD
Annual Report: CHOP Scientists' 2025 Highlights with Struan Grant, PhD YouTube video by CHOP Research Institute

www.youtube.com/watch?v=XGvE...

02.01.2026 19:43 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Congratulations to @khanhtrang.bsky.social. Delighted to contribute to this V2G across ~60 cell types & 15 autoimmune GWAS reports. @chopresearch.bsky.social @penngenetics.bsky.social

08.12.2025 15:52 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Thank you for sharing! It's members like you that demonstrate the quality of the programs that ASBMR offers.

We hope people will take advantage of the opportunity to work with the best and brightest in bone and mineral research! 🦴

25.11.2025 16:36 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Children’s Hospital of Philadelphia Researchers Identify Genetic Factors Influencing Bone Density in Pediatric Patients Understanding the causal gene was related to the dynamic between osteoblasts, which form new bone tissue, and osteoclasts, which break down old bone tissue. When children are growing, osteoblasts are far more active to help achieve proper bone growth.

An outline of our recent bone 🦴 papers - with @j-a-mitchell.bsky.social and Babette Zemel. @chopresearch.bsky.social @penngenetics.bsky.social

www.chop.edu/preview-link...

20.11.2025 12:11 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
ASBMR Student Cohort Program A new cohort program designed for undergraduate, graduate, and medical professional students involved in the bone, mineral, and musculoskeletal field. This cohort program provides accepted applicants

As an ASBMR Ambassador, I invite you to check out the ASBMR @asbmr.bsky.social 2026 Student Cohort Program www.asbmr.org/student-cohort. The application deadline has been extended to November 28, 2025.

19.11.2025 16:09 πŸ‘ 2 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
ASBMR Student Cohort Program A new cohort program designed for undergraduate, graduate, and medical professional students involved in the bone, mineral, and musculoskeletal field. This cohort program provides accepted applicants

As an ASBMR Ambassador, I invite you to check out the ASBMR @asbmr.bsky.social 2026 Student Cohort Program www.asbmr.org/student-cohort. The application deadline has been extended to November 28, 2025.

19.11.2025 16:09 πŸ‘ 2 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Post Doctoral Research Fellow – Circadian Biology and Genomics - Philadelphia, Pennsylvania (US) job with Children's Hospital of Philadelphia | 12846607 A postdoctoral fellow is needed to join a strong team involved in spanning both dry and wet lab approaches.

@shaonsengupta.bsky.social and I are still hiring! Please DM us if interested

www.nature.com/naturecareer...

04.11.2025 15:50 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Penn Genetics @penngenetics.bsky.social and CHOP Genetics @chopresearch.bsky.social are at #ASHG25 Booth #1319 - come on by!

17.10.2025 13:25 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I'll again be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 1.30-2.30pm today - come on by!

17.10.2025 12:37 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Come see Matt Pahl (@pahlmc.bsky.social) present at the #ASHG25 Session on Predicted Effector Genes.

Here are the details for the session:
Learn about the current predicted effector gene landscape
11:45AM-1:15PM ET
Room 259A

17.10.2025 12:33 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I'll again be at the #ASHG25 Penn Genetics
@penngenetics.bsky.social Booth #1319 3.30-4.30pm today - come on by!

16.10.2025 12:24 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Come see Winter Bruner, PhD today: "A comprehensive MPRA of both trans-ancestral genome-wide and suggestively-associated childhood obesity loci implicates a role for CBLN4 in microglia". Room 205ABC Thurs 11.00-11.15 Key contribution from Molly Ridler

16.10.2025 12:23 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I'll be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 3.30-4.30pm today - come on by!

15.10.2025 12:19 πŸ‘ 6 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Check out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319

Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion

Tuesday, October 15 - Thursday, October 17

14.10.2025 15:09 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 3

Great collaboration with the Joan O'Brien team - come see Vrathasha Vrathasha today: "3D genomic approaches mapping accessible chromatin and architecture implicate causal risk variants in primary open-angle glaucoma pathogenesis". Key contribution from @pahlmc.bsky.social. 10.45-11.00am Room 206AB

15.10.2025 12:10 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Come say hi at the #ASHG25 poster session today! I’ll be discussing my work on identifying pathogenic non coding variants in undiagnosed children. Poster 4083W. See you there! #ASHG2025 #Genetics #CHOP

15.10.2025 10:49 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Can’t believe #ASHG25 is finally here! Excited to share what I’ve been working on as lead analyst for the Global Lipids Genetics Consortium πŸ§¬πŸ‘©β€πŸ’»

Join me at the Plenary Session on Friday, Oct 17 (5–6:30 PM) β€” I’ll be presenting some unpublished results from our genome-wide interaction study πŸ‘€

14.10.2025 19:15 πŸ‘ 23 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Our team is excited to meet folks at #ASHG25 #kidneyomics

14.10.2025 18:07 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

I'll be at #ASHG25 this week! Check out my poster Wed 2:30-4:30, at 5071W.

"Bridging the GWAS-eQTL colocalization gap with insights from caQTL analyses" with @struangrant.bsky.social and Laura Almasy

14.10.2025 19:13 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

@khanhtrang.bsky.social @maxdudek.bsky.social @atothezphd.bsky.social @agacita.bsky.social @pahlmc.bsky.social

14.10.2025 19:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Our #ASHG25 poster activities each day:

1097W Khanh Trang: Bone*
5071W Max Dudek: caQTLs
8042W Amber Zimmerman: Sleep
4083W Anthony Gacita: Pathogenic noncoding variants
9252T Mary Ann Weidekamp: Neuro & metab LDSC
5047T Ekta Singh: Ciliopathies
9206F Matthew Pahl: Glaucoma V2G*

*Reviewers’ Choice

14.10.2025 19:17 πŸ‘ 4 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0