Shhhh. That's not the right narrative!

This paper makes a ton of technical advances to enable second-timescale full-body calcium imaging of ~transparent Zebrafish. By doing so, they make multiple discoveries spanning cellular, organ and multi-organ scales.

As a consequence, most studies focus on pairwise organ interactions in isolation, leaving out the dynamic, system-wide processes and context.

3/N

However, technological limitations have shackled research to partial observability: existing tools either capture isolated subsystems or the whole organism but only at coarse scales, sacrificing cellular or temporal resolution.

2/N

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors[1][1],[2][2]. Physiology seeks to elucidate the intricate networ...

www.biorxiv.org/content/10.1... is the most exciting new advancement in #neuroscience I've seen in a while!

A brief 🧵: The shared dream of neuroscience and physiology has been to understand how behavior and homeostasis emerge from continuous loops of exchange between brain and body.

1/N

What happens when "If at first you don't succeed, try again?" meets modern ML/AI insights about scaling up?

You jailbreak every model on the market😱😱😱

Fire work led by @jplhughes.bsky.social
Sara Price @aengusl.bsky.social Mrinank Sharma
Ethan Perez

arxiv.org/abs/2412.03556

Answer: defending even a *single* threat is still not yet achievable by today's jailbreak defense toolkit 😱

We also identify and highlight two key open challenges we hope future defense work can focus on

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🚨🛡️Jailbreak Defense in a Narrow Domain 🛡️🚨

This paper disentangles whether jailbreak defenses struggle due to needing to defend against so many diverse threats OR the innate hardness of defending against a single threat

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I'm disappointed I needed to say this on an #ICLR2025 submission:

"While the authors are well within their rights to challenge prior work, suppressing contradictory evidence is antithetical to the scientific process and muddies the research community's understanding"