Vanja Tepavcevic

Maybe it would be possible to combine your system with the use of specific sensors/indicators in oligodendrocytes (metabolites, glutamate etc) to potentially capture how and when it starts reacting to axonal damage, even before myelin changes become obvious?

But in models where many axons are damaged simultaneously, the threshold is reached, and then myelination by the oligo will be affected.

Congrats, great work! If axo-oligo signalling regulates the maintenance of myelin and oligos maintain up to 50-80 internodes, then it is likely that a loss of a single axon ( or 2) might not reach a "threshold" to let the oligo know myelin maintenance needs to be modified.

And much more... career development advice, mentoring workshops, social events in the framework of the Bay of #Plentzia.

#AIGS26 | Day 3 (Sept 18) 🧠

Session 4: "Innovative Experimental Approaches to Studying Glial Cells.".

Speakers:
🔬 Fabio @fabiocava.bsky.social #brainoids
🔬 Minou @minoudj.bsky.social #zebrafish
🔬 Federico N. @soriafn.bsky.social #twophoton
🔬 José P. @jplopez-atalaya.bsky.social #transcriptomics

#AIGS26 | Day 2 (Sept 17) 🧠

Session 3: "The Integrative Functions of Glial Cells in Neural Circuit Physiology"

Speakers:
🔬 Rosa @paolicellilab.bsky.social
🔬 Marta @navarrete-llinas.bsky.social
🔬 Cecilia Angulo @inserm.fr
🔬 Juliana M. Rosa @hnparaplejicos.bsky.social

#AIGS26 | Day 1 (Sept 16) 🧠

Session 2: "New Insights on Glial Cells in Neurodegeneration: A Focus on Metabolism".

Speakers:
🔬 Alberto Pascual @ibis-investigacion.bsky.social #microglia #metabolism
🔬 Maite Solas @unav.edu #astrocytes #alzheimers
🔬 Vanja @tepavcevicvanja.bsky.social #myelin #MS

Achucarro Glia School 2026 - Achucarro Basque Center for Neuroscience NOTICE FOR THIS EDITION The Organisation will select participants among the candidates who correctly complete the (pre)Application Form (check the right column). Candidates commit to paying the tuitio...

#AIGS26 | Day 1 (Sept 16) 🧠

Session 1: "Understanding Glial Cells: Cellular Breakthroughs".

Speakers:
🔬 Amanda Sierra @sierralab.bsky.social #microglia #phagocytosis
🔬 Juan Pedro Bolaños @bolanosjuanp.bsky.social #metabolism #mitochondria
🔬 Arne Battefeld #oligodendrocytes #signaling

Achucarro International Glia School is back! #AIGS26

Registration period is already open, and the final programme accessible.

Looking forward to this edition in #Plentzia

www.achucarro.org/gl...

#astrocytes #microglia #oligodendrocytes #glialcells

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B-cell repertoire and p...

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity

onlinelibrary.wiley.com/doi/10.1002/...

What role do oligodendrocytes play in Alzheimer's? 🔬

We're pleased to support a major new project led by @sj-marzi.bsky.social, @dervissalih1.bsky.social, @nottalexi.bsky.social & @rikeshrajani.bsky.social, to investigate how these cells influence neurodegeneration👉 www.ukdri.ac.uk/news-and-eve...

🧠 New funding opportunity for all scientists working on brain organoids 🧠

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Thrilled that our paper is now published. It’s been a real privilege to work on this project together with co-first author @ara-donia.bsky.social, under the supervision of @lyons-lab.bsky.social, and with such an outstanding team in Edinburgh and internationally!
www.science.org/doi/10.1126/...

Progression independent of relapse and MRI activity and treatment strategies in multiple sclerosis Rollot et al. analysed disability progression in a registry cohort of patients with multiple sclerosis who were treated first with high- versus moderate-ef

If we want to understand the biology of non-inflammatory disability progression in MS and find therapies that actually work, we need to consider both relapse and MRI activity. This is the approach we need: academic.oup.com/brain/articl...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of @lyons-lab.bsky.social, the work of co-first author @juliavdkorput.bsky.social and wonderful collaborators in Amsterdam and Oregon.
www.science.org/doi/10.1126/...

🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...

Reminder that, as of the latest reports, Liam Ramos is still in prison in Texas - now for 5 days.

His parents are legal asylum seekers with no criminal record.

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
www.nature.com/articles/s41...

A Question of Origins: Non-neuronal Sources of Amyloid-β - Neuroscience Bulletin Amyloid-β (Aβ) plaques and neurofibrillary tau tangles are hallmarks of Alzheimer’s disease (AD). While the intracellular localization of tau tangles within neurons nominates them as the primary produ...

Where does Aβ come from in Alzheimer’s disease? 🔍

In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.

link.springer.com/article/10.1...

📢Calling all @cam.ac.uk neuroscience students: Applications are still open to join our wonderful CamBRAIN team!🧠

This is a fantastic opportunity to get involved in the committee of one of the largest student neuro societies in the UK!
More details in the comments👇
Apply by 26/01: lnkd.in/eMZ3P286

Huntington’s disease: treatments are finally on the horizon after research breakthroughs Sadly, there is no cure for Huntington’s disease. But a couple new research papers suggests this may be about to change.

Huntington’s disease: treatments are finally on the horizon after research breakthroughs theconversation.com/huntingtons-...

#Huntingtons #dementia #science #neuroscience #neurology

EBV is required for the development of multiple sclerosis, but it’s not known how a common virus leads to disease. 3 exciting new papers in @cellcellpress.bsky.social provide major insights into how this may occur:

Extremely interesting research and thread!

🚨 REGISTRATION NOW OPEN – CAJAL CONFERENCE 2026

“Novel Insights Into Brain Energy Metabolism in Health and Disease”

📍 April 15–17, 2026 | Cádiz, Spain

🔔 SENC Fellowships available
🔔 20 slots for Oral Communications

👉🏻 Register here:

amconferences.eventsair.com/senc-cajal-c...

👇🏻 SPEAKERS

The Cajal Conference 2026 on energy metabolism in health and disease in the wonderful city of Cadiz promises to be exceptional and exciting due to the impressive list of speakers. Registration with limited places is now open.

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com
www.nature.com/articles/s41...

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant glio...

Glial progenitor cells, including OPCs, with IDH mutations (rather than neural stem cells) may be the cellular starting point for the development of IDH-mutant glioma. Science www.science.org/doi/10.1126/...

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

How is myelin remodelled without compromising myelin integrity???
www.biorxiv.org/content/10.6...

Somatic evolution following cancer treatment in normal tissue - Nature High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factor...

Comprehensive study looking at the genomic effects of chemotherapy on normal tissues.

Somatic evolution following cancer treatment in normal tissue | Nature

www.nature.com/articles/s41...