How do DNA sequence and histone composition modulate nucleosome plasticity? We investigated this by comparing the behaviour of 40 chemically different nucleosomes. Check our preprint below.
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure.
Learn more in a new #SciencePerspective: https://scim.ag/3Yfn1T3
Want to learn about how we use computational approaches at different scales to study biomolecular condensates?
Check out our latest review, out in Advances in Physics X
@juliamaristany.bsky.social @alinaemelianova.bsky.social
@rcollepardo.bsky.social
www.tandfonline.com/doi/epdf/10....
Huge congratulations, Daniel!!
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
These ones yes, as they are single component and the fibers are regular. But they can be heterogeneous too, one of many possible examples here: www.biorxiv.org/content/10.1...
Thank you♥️♥️♥️
In collaboration also with @huabin-zhou.bsky.social, Jorge R Espinosa and David Farré-Gil
with contributions from super talented @yifangccc.bsky.social @juliamaristany.bsky.social @janhuemar.bsky.social and @nachper.bsky.social from our group
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
Many thanks to @jojdavies.bsky.social for inviting us to take part in this exciting study, combining MCC ultra with simulations to explore how the biophysical properties of chromatin govern its structure in living cells.
Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social
Check out our new work, led by talented @janhuemar.bsky.social, where we uncover that pioneer factor Oct4 remodels chromatin for DNA access not by opening it but by exploiting nucleosome breathing and forming clusters 🔥🔥🔥
We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥
If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding
Simulations by superstar @juliamaristany.bsky.social
It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️
So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...
In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin
Looks amazing!! Congratulations 🔥🔥🔥
We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/
To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social
María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social
Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social
Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social
Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social
Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social
Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social
First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social
Starting now #BPS2025 @mgo-bps.bsky.social
Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium.
TODAY at 1:30 pm
