Martin Sauvageau

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...

RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP

Home | Mtl RNA Salon

Don’t forget today - MTL RNA salon. 4PM at IRCM

www.mtlrna.org

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

codon usage About the Conference Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...

Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.

sites.google.com/view/codonus...

😂 I honestly don’t know how you managed to salvage this one!

tRNA-overlapping long non-coding RNA loci repress codon-biased genes Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions interact between chromosomes and depend on each other’s transcription. tROL perturbations silence codon-biased genes i...

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

Congrats Jen

While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior.

These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy

🧵 by the amazing @christeldepienne.bsky.social 👇

1/3

🎉 Congratulations to Dr. Jean-François Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research—particularly on cell migration and metastasis—as well as his commitment to collaboration and innovation in health. A well-deserved recognition! 👏

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health.
🔗 bit.ly/3HGWhX3

Proud to see this work on a new #machinelearning model, ECSFinder, now online academic.oup.com/nar/article/...

This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick.

Full thread 👇🏼

Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis - Nature Biotechnology Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Repeat-element RNAs integrate a neuronal growth circuit SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Canada Excellence Research Chair (CERC) in RNA Neurotherapeutics Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at…

🚨 @healthsciences.mcgill.ca‬ is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics

Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.

✍ Apply by July 4:

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...

Congrats Igor and team. Very nice work. Chaserr is such a beautiful example of how lncRNAs can be important in disease and could potentially be targeted for therapeutic purposes.

Hello out there! Are you looking for a friendly community to share your RNA research and hear about some cool RNA biology? Register for @trendrna.bsky.social on July 10-11 now! Oral abstract deadline is May 30th! Co sponsored by @rnacanada.bsky.social!

The IRCM #RNATherapeutics Core Facility is also part the AReNA's Network for the Development & Production of RNA Therapeutics of Quebec (DePTAQ) together with @mcgill-research.bsky.social @d2rmcgill.bsky.social and @usherbrooke.bsky.social

You will play a central role in the core facility services and in the development of different modalities of #RNA therapeutics (#ASO, #siRNA, #mRNA-LNP). This position offers a unique opportunity to contribute to cutting-edge research and be part of the vibrant Montreal RNA community.

Research Assistant - RNA Therapeutics Core Facility

We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal.

More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...

A 🧵 to walk those interested through this paper...

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...

www.science.org/doi/10.1126/...

A promising genetic treatment tailor-made for a baby born with a rare disorder For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.

For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.

Poster for RNA Canada ARN Education Series Perspectives on RNA: RNA Chemistry and its applications Wednesday, May 21st, 3-4:30 pm EST / 12-1:30 pm PST

Next week! RNA Canada sponsored series:
Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...

Exogenous RNA surveillance by proton-sensing TRIM25 Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

Beautiful paper

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...

Very interesting study and neat mechanism. Congrats Josh and team.

🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN

Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !

📅5 mai 2025 🕐12h45

💡 En savoir plus : mcgill.ca/dna-to-rna/f...

#ACFAS8

🚨 Appel à proposition 🚨

D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN !

$350 000 pour 2 ans
Date limite : 15 mai 2025

🔗https://buff.ly/Ub5D45x

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461 Canada Excellence Research Chairs (CERC)

If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details.
www.nature.com/naturecareer...