Registration is open for @dmmjournal.bsky.social 2026 meeting 'Innovative Preclinical Models for Pediatric Cancer Research' organised by James Amatruda amatrudalab.bsky.social, Pratiti (Mimi) Bandopadhayay, bandolab.bsky.social, Ana Banito & Elaine Mardis. Find out more bit.ly/46r84Ca #DMM2026cancer
They figured out meander tail mouse has an Mysm1 mutation!
I have been curious about this mouse since I got into the cerebellum field, as this mouse is the only model identified so far that has defects preferentially in the anterior cerebellum. very cool follow up!! www.biorxiv.org/content/10.6...
Hey Chromatin Friends!
Long time no chromatin question...
For many of you, CUT&x (RUN/Tag) works really well but some of you have had their frustrations with CUT and "gone back" to ChIP-Seq. Can you share your experiences in the comments!?
Would love to hear from you!
Sharing is appreciated : )
in case you are interested, please get in touch! Application requirements include at least one first author paper published and a PhD within four months of the submission deadline (March 31st). other Information and our project details are in the link above!
Ramsey Najm and I have a joint postdoc position advertised through the @hlsalliance.bsky.social Interinstitutional Postdoc call! Our project proposes to generate better posterior cerebellar organoids to improve fidelity of pediatric medulloblastoma models.
www.health-life-sciences.de/opportunitie...
The figure shows the key features of human cerebellar patterning and gene expression. Panel A: The midbrain –hindbrain boundary is set at ∼4-5 post-conception weeks. The isthmic organizer secretes the morphogens to set the boundary. Panel B: around 10 weeks post conception, two progenitor pools are specified, including the ventricular zone, which generates all inhibitory neurons and glial cells, and the rhombic lip, which generates all excitatory neurons. The external granule layer is a second germinal zone producing the abundant excitatory granule neurons of the cerebellum. Panel C: at later stages in development, the cerebellum becomes highly foliated and adopts its characteristic three-layer structure. Panel D: major cell types of the mature cerebellum include Purkinje cells, granule cells, unipolar brush cells, GABAergic interneurons and cerebellar nuclei.
Esther Becker, Simone Mayer and @lenakutscher.bsky.social teamed up to summarise current approaches for generating #cerebellar #organoids and advocate for the establishment of rigorous quality control standards to ensure reproducible, high-quality research.
Read doi.org/10.1242/dmm....
Thanks Heike :)
We hope our data can be useful to you, and to increase its usability, we've generated an exploratory web app as a resource and starting point to examine our data on the @kaessmannlab.bsky.social website apps.kaessmannlab.org/HindbrainExp...
We also show how our atlas can be used to dissect the role of HOX transcriptions factors in hindbrain patterning. We also examine pediatric gliomas, where we identify subtle yet coordinated shifts in gene expression context that define oncogenic transformation.
Our results reveal how context-specific transcription factor activity emerges from the interplay between inductive transcriptional signals and permissive chromatin states, together driving the cellular heterogeneity observed across hindbrain development.
Our extensively annotated atlas enables systematic reconstruction of neuronal and glial lineages, offering a high-resolution view of the gene expression programs and underlying cis-regulatory elements that drive their development.
We integrate 594,817 single-nuclei transcriptomes and 422,568 chromatin-accessibility profiles across the full developmental continuum from early embryonic stages to adulthood.
Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by: 1. Meticulously annotating cell clusters 2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements 3. Using deep learning to identify regulatory syntax 4. Resolving context-specific TF activity
Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...
thanks Cedric!!
Some friends and I wrote a review with @biologists.bsky.social !! Together with Esther Becker and Simone Mayer, we explore the state of the cerebellum organoid field and offer practical guidance on getting this model system started in your own lab. journals.biologists.com/dmm/article/...
From my work on gerrymandering, I know that New Jersey politicians play dirty. Now my campaign faces its first test.
To beat their petty games, I need at least 1,000 signatures from Democrats and unaffiliated voters in the 12th District. It's cold work. To help, sign up at SamForNJ.org - or DM me!
News from central Jersey: I'm running to represent New Jersey's 12th Congressional District.
By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come!
samwang.substack.com/p/entering-t...
I've started my own lab 🎉
PhD/postdoc positions available - reach out if curious about cerebellum evo-devo and autism spectrum disorders.
We’re based at Uni Tartu, Institute of Genomics (home to Estonian Biobank), and funded by @simonsfoundation.org @embo.org, and the Estonian Research Council.
Today I made a small but momentous start to work in 2026 by changing a single number.
I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”.
Stay tuned for more file updates on 1st January 2027.
I love this live version of the new @themountaingoats.bsky.social song.
🎶"There's always a clock ticking somewhere."🎶
youtu.be/pv53gRqjvxY?...
in the pit
This entire weekend
The @dkfz.bsky.social PhD Program is open, and the Mall Lab is recruiting PhD students.
1: in vivo and organoid models to study and treat autism associated disorders.
2: cancer cell plasticity in brain tumors using single cell genomics and perturbation screens.
Apply now: www.dkfz.de/en/career/in...
This will be a very exciting meeting!
Looking forward to see you there
Please spread the word
Olya Yarychkivska
Linker cell at the tail of a C. elegans male
Olya Yarychkivska of @rockefeller.edu will kick off the #SDBPostdocSeminar with her talk "Myelin regulatory factor 1, identified by single cell transcriptomics, primes a migrating cell for non-apoptotic cell death" Image: Linker cell at the tail of a C. elegans male
Yayyy so glad it’s finally official!!! ⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️
Emmy Noether grant for DKFZ researcher Jens Puschhof.👏 With this grant, he aims to decipher the role certain intestinal bacteria play in the earliest stages of colon cancer development and how this process can be halted.
t1p.de/aoeve
@jenspuschhof.bsky.social
Paracetamol remains an important option to treat pain or fever in pregnant women.
Following rigorous assessment of the available scientific data, we find no evidence that taking paracetamol during pregnancy causes autism in children.
Read more 👉 www.ema.europa.eu/en/news/use-...
I am more than thrilled to announce that I will be starting my own lab at the Neuroscience Department at MUSC in November 2025! We will be studying the origin of pediatric brain cancers through the lens of brain development!
My lab is hiring see here: cschmidtlab.xn--com-gr63bea
Like our sister journals, you can also submit an additional language abstract at @dev-journal.bsky.social and we cater for non-Western characters for author names. Did you know Development also facilitates retrospective author name changes?
