Similar tumors can often respond very differently to immunotherapy. Why? A simple mathematical model reveals the possibility of two alternative evolutionary strategies, dictated by mutational loads www.sciencedirect.com/science/arti...
Latest paper of the @tanjaslotte.bsky.social lab now out as a preprint in bioRxiv ✨️😁 👇
The final part of the story: "The arduous path to obligate asexuality in Daphnia" is out in #ProcB 🥳 royalsocietypublishing.org/rspb/article.... 1. Instead of comparing long-established asexuals to sexuals, we generated new asexual lineages to observe the transition in action.
Many organisms, including humans, reshape their environments in ways that influence the conditions faced by future generations. We ask whether this can favour biological variation with @irisprigent.bsky.social in our new paper. Thanks to @dee-unil.bsky.social @snsf.ch
www.pnas.org/doi/full/10....
We are offering a fully funded two-year postdoctoral position focused on sex chromosome evolution and speciation in the *Jaera albifrons* species complex. Please find the advertisement attached. We welcome applications from interested candidates. Join us :-)
I thought about what to write today, but I am so tired of us all ignoring the twelve years that Ukraine is defending Europe. I remain in awe of the resilience of the people of Ukraine, and will keep supporting them. This artwork is by Ukrainian artist Bogdana Chilikina: ‘TUT LYUDY’ (‘PEOPLE HERE’).
Four years ago, Russia launched its full scale invasion of Ukraine along the entire shared border and from Belarus. Millions have been affected, with cities and villages destroyed and families torn apart. Eternal memory to all the heroes who gave their lives for the country’s freedom. #Ukraine
Anna Colin Lebedev, spécialiste de la Russie, décrit la fragilité du pouvoir de Poutine : «Un arbre qui pourrit de l’intérieur tout en donnant une apparence extrêmement solide. Il suffira un jour d’une pichenette pour qu’il s’effondre, comme cela s’est passé pour l’URSS.» ➡️ bit.ly/4tLsmjP
The evolution of condition-dependent self-fertilisation https://www.biorxiv.org/content/10.64898/2026.02.15.705963v1
🌺 New preprint out with John Pannell and @charlesmullon.bsky.social ! 🌺
We show that selection broadly favours a form of plasticity for the selfing rate where individuals adjust their mating behaviour to their condition — their overall vitality owing to their genetic background and environment. ⤵️
⚡️ IOC banned Vladyslav Heraskevych, a Ukrainian skeletonist, from using a custom helmet featuring images of Ukrainian athletes killed by Russia at the 2026 Olympics.
📷: DW
In #GENETICS, @hildeschneemann.bsky.social and John Welch introduce a simple fitness landscape model to predict hybrid fitness with arbitrary ploidy and an arbitrary number of hybridizing lineages using data from #maize and rye. buff.ly/E24fZsM
@jochenwolflab.bsky.social
Where do potentially harmful mutations accumulate? We have an answer in birds. Congratulations Fidel for wonderful paper!
doi.org/10.1093/gene...
Preprint finally out! I show that eco-evo feedback can drive a tipping point where genetic drift overwhelms adaptation. This can result in a contraction of a species' range border or range fragmentation. Fragmentation is abrupt and arises readily under rapid temporal change. doi.org/10.1101/2025...
🎙️🔊📻 New Heredity podcast!
From PopGroup 59 in Lille.
Plenary speaker Florencia Camus talks about:
1. The conference
2. Conflict and coadaptation between the mitochondrial and nuclear genomes
Listen here: shows.acast.com/heredity-pod...
Pleasure giving a recap of a wonderful PopGroup conference, and the opportunity to talk about my research.
🔥
New paper out in PNAS!!! 🎉
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
www.pnas.org/doi/10.1073/...
Out in @science.org this week: SIPS binds to a conserved region of SRK to control interspecies incompatibility in Brassicaceae. This contrasts with SRK's variable region, which is involved in self-incompatibility interactions.
www.science.org/doi/10.1126/...
#plantscience
L'Ukraine fait face à une vague combinée de froid glacial et de bombardements russes. L'inaction de la "coalition des volontaires" devient chaque jour plus insupportable. L'Europe rate une fois encore son rendez-vous avec l'Histoire. #SkyShieldNow @fpetit.bsky.social @nicolastenzer.bsky.social
The last few days have provided Europeans with an important lesson on how to handle Trump. Don't beg, don't bluster, but do use the leverage you have to impose costs of him for his reckless behavior. European Greenland actions should inform their Ukraine policy. open.substack.com/pub/phillips...
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
Balancing selection alert!! 🧬🧪
New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.
#Popgen #MolecularEvolution #EvoBio #Science
🧬 What does the starting material from which genes could emerge #denovo look like?
🌱 We used #RiboSeq to investigate the landscape of translated de novo ORFs in 3 #Arabidopsis species, and how they might be linked to gene birth!
📝 Check out our preprint here:
doi.org/10.1101/2025...
Cow Tools!
We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them
It is now, only now, that we have discovered THEY CAN USE TOOLS
Here I describe our study
(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social
Characterising the detectable and invisible fractions of genomic loci under balancing selection https://www.biorxiv.org/content/10.64898/2026.01.13.698512v1
We (with Fanny Pouyet and Brian Charlesworth) provide a theoretical perspective on rescaling forward simulations in population genetics, along with some guidelines:
arxiv.org/abs/2601.05367
Back in Toulouse, but very happy with my first PopGroup @popgroup2026.bsky.social. Every time I come to Lille, I remember how pleasant the city is (here it was even better with the snow) and how much I enjoy good times with my friendly collaborators there.
Always inspiring to start the year at @popgroup2026.bsky.social !
If you were there and want to learn more about pangenomes, there’s still time to register for our meeting in Edinburgh in June, co-organised with @charlottewright.bsky.social & @joanameier.bsky.social royalsociety.org/science-even...
It was an honour to talk at PopGroup!
Thanks to the organisers for making it a very memorable event 🥳
