Rupesh Jayachandran

Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁

Preprint out now 🦟🦟🦟

www.biorxiv.org/content/10.6...

Pre-assembly of biomolecular condensate seeds drives RSV replication Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!

rdcu.be/e1bBW

Our paper is finally out!
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology

Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...

Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info.

Deadline 8 Feb. Apply here:
umustipendie.varbi.com/en/what:job/...
#virus #virology #teamtomo #cryoEM

Systematic profiling of growth interactions in human gut microbiome species Microbial interactions shape the composition and stability of the human gut microbiome. Yet, the molecular mechanisms underlying these relationships remain poorly understood. Here, we systematically p...

New preprint from the lab is out! 🥳

We systematically profiled all pairwise growth interactions between 36 representative human gut microbiome strains, and delved deeper into the molecular mechanisms behind specific growth interactions.

www.biorxiv.org/content/10.6...

👇

Thanks Evans! 😊

Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access www.biorxiv.org/content/10.1101/2025.11.02.686081v1 #cryoEM

Thanks Lars! 😊

Very happy to share our work on the Langya henipavirus nucleoprotein with everyone! 🥳

Check out the preprint to find more about how a serendipitous finding led us to this amazing story!

Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/

Läs hela intervjun med Max Renner: Mottagare av Pandemifondens pris 2023 | Virus- och pandemifonden Läs hela intervjun med Max Renner: Mottagare av Pandemifondens pris 2023 Sedan Max mottog Pandemifondens pris 2023 har mycket hunnit hända. Priset har inte bara möjliggjort viktiga framsteg i hans fo...

Very grateful for the support from Pandemifonden and it was a pleasure to share a bit of what our team has been up to 😊

(In Swedish)

www.linkedin.com/feed/update/...

From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report…

My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social

Please check it out 😊

www.sciencedirect.com/science/arti...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

Repost appreciated:

Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.

Deadline 4 May. More info: www.carlsonlab.se/join/

PhD position in Chemistry, with a specialization in biochemistry The Department of Chemistry is opening a PhD position in Chemistry with a specialization in biochemistry. The thesis project will focus on drug resistance mechanisms in microbiome species, and is part

We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...

Postdoctoral position to study Gram-positive Type 4 Secretion Systems - Umeå, Sweden job with Umeå University | 12837918 A two-year Postdoctoral position for studies of Gram-positive Type 4 Secretion Systems that facilitate the spread of antibiotic resistance

We are looking for a postdoc!

Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!

Please share!

www.nature.com/naturecareer...

Been thinking about creating a collection of good protein structure figures, as inspiration for my own work.

#1 www.nature.com/articles/s41...

2024 S2C2 Single-Particle Cryo-EM Image Processing Workshop - YouTube This playlist contains six recordings covering single particle cryo-EM data processing in CryoSPARC from the 2024 Single-Particle Cryo-EM Image Processing Wo...

1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.

www.youtube.com/playlist?lis...

Given the growth of this forum in the last couple of weeks, I'm reposting our open PhD position. Come do a PhD on virus replication using our world-class, in-house cryo-EM facility. Dynamic and friendly infection biology community. Deadline in <2 weeks!