Really interesting approach to mood regulation!
news.harvard.edu/gazette/stor...
02.10.2025 11:28
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Really interesting approach to mood regulation!
news.harvard.edu/gazette/stor...
Got a NOA for a new R01 from #NIAAA this week. Looks like new awards are finally moving! Also year two is already listed as pending?
Updating my analysis now that August data should be relatively complete.
Not great news...
The rate of investment of the appropriation is not increasing and it seems unlikely that the entire appropriation will be committed this year.
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#NIAAA funded 5 new R01s last week, bringing the FY25 total to 13. 10 of 50 grants funded last week were new (not renewals). Perhaps marks a shift towards funding of new awards in the final stretch?
Yes, unfortunately it affects so many families and is so multifaceted. I wish the best for your nieces and the rest of the family!
This NIH-funded study helps us understand more about the brain mechanisms of familial risk for alcohol use disorder, which can help us develop new methods to improve health outcomes for people who are at risk for addiction. 5/5
Family history was related to greater activation in the nucleus accumbens, suggesting a heightened sensitivity to rewards, but not with brain differences in future thinking or cognitive control. Greater nucleus accumbens activation was also related to steeper escalations in alcohol drinking. 4/5
We examined brain systems for future thinking, cognitive control, and reward processing during an fMRI delay discounting task and tested these as mediators of the relationship between family history and alcohol drinking trajectories. 3/5
Family history is associated with more impulsive decision-making and greater alcohol use. We hypothesized that these relationships are driven by particular brain differences in regions that contribute to decision-making for delayed vs. immediate rewards. 2/5
Family history of alcohol use problems increases reward-related brain activity, leading to increased drinking trajectories in young adults. New preprint: www.medrxiv.org/content/10.1... #addiction #fMRI #NIAAA 1/5
The numbers for #NIAAA are especially bleak. No new (Type 1) NIAAA awards posted on Reporter last week. With 4 weeks to go, there is an immense amount of ground to make up to ensure that novel alcohol research is supported and investigators can support their work, their staff and trainees.
They seem to be prioritizing type 5 grants right now, around 10 per day in August.... Not sure how many of those they need to get through PO told me to expect a "funding decision" for my pending grant before 9/30 😬
Actually 33 (one new)!
Only last week one for NIAAA...?
I'm thrilled to announce that I just got my first R01 from NIAAA! 1R01AA031007. I'm hiring here in Baton Rouge, LA, so message me if you are interested in working on this alcohol grant, or on other projects in lab involving opioid use!
So are we all resubmitting next cycle, or what?
NIH progress on new R01s in FY 2025 drugmonkey.wordpress.com/2025/08/18/n...
This is figure 3, which shows key neural mechanisms linked to early adversity.
Adverse experiences in early life affect brain development. A Review in Nature Reviews Neuroscience discusses evidence for how these adversity-induced changes to human brain architecture alter developmental trajectories that may underpin adult psychopathology. go.nature.com/45xZOii 🔒
College students pursuing careers in science or medicine can learn skills for grad school through the Summer Neuroscience Internship Program at the University of Florida, now celebrating its 10th year. SNIP provides mentorship, hands-on lab work and more.
Learn more: bit.ly/4kdYPJC
fMRI Peeps - I remember reading a paper, years ago, focused on identifying regions for brain-association analyses based on peak inter-individual variance (rather than peak activation), but a 20-min search failed to recover it. Suggestions? Thx!
access link: authors.elsevier.com/a/1l8AV3AZg%...
👏👏👏
fMRIPrep Lifespan: Extending A Robust Pipeline for Functional MRI Preprocessing to Developmental Neuroimaging | bioRxiv www.biorxiv.org/content/10.1...
Psychiatric disorders share genetic roots, but the mechanisms are unclear. With exon-level brain data, we linked common & rare variants to 110 core genes in pathways such as cortisol & dopamine cascades, mainly in excitatory neurons, offering new therapeutic targets 🧠✨ www.nature.com/articles/s41...
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New study in JAACAP with wonderful collaborators, Shanting Chen and Catalina Lopez-Quintero: Racial discrimination alters subcortical brain connections in minority youth, speeding up maturation. Changes tied to mental health issues, especially in girls #ABCDStudy authors.elsevier.com/sd/article/S...
⚕️ NEW RESEARCH! 🧠 👀
Haque et al. report a case of chronic alcohol use disorder #AUD that had reduced cravings & stopped drinking following a traumatic brain injury that damaged frontal lobe connectivity.
https://bit.ly/44k6WzN
#addictionsci #BrainInjury
(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...
Funded by National Institute of Mental Health (NIMH)
Confirmed (by many sources) news about 50 NIH Study Sections being allowed to announce meetings in the Federal Register.
As usual, MANY more questions than answers...
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Screenshot of article title, authors, and abstract.
New Hurd Lab paper in Molecular Psychiatry explores how cannabidiol can help reduce anxiety linked to specific triggers.
Learn more about our findings 🧵 and read the full paper here: www.nature.com/articles/s41... (1/7) #Neuroskyence #WomenInSTEM #CBD
Would be great to ask about Advisory Council meetings too. How many people (like me) have a grant that was scored favorably but still see 'pending council review' on ERA Commons? As I understand it no ACs have met since 1/20/25 ie no new grants have been approved in any institute. Is that true?