Bérénice A. Benayoun, PhD

Excited to share our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by Dr. #MinhooKim, published online today at @nataging.nature.com, where we describe surprising findings on the gut/ovary axis. 🧪🖥️🧬. A 🧵1/11 www.nature.com/articles/s43...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social
doi.org/10.1038/s435...

✨Registration is OPEN for the 2026 FASEB on Epigenetics in Aging and Disease in Malahide, Ireland!✨
Featuring @denadubal.bsky.social and Yang Shi from @ludwigcancer.bsky.social as Keynotes. Speaker slots available!

With: @bbparis1984.bsky.social Ashby Morrison, Ernesto Guccione

Fecal transplants from older mice found to significantly improve ovarian function and fertility in younger mice A new study details how fecal transplants from older female mice significantly improve ovarian function and fertility in young mice.

Fecal transplants from older mice have been shown to enhance ovarian function and fertility in younger mice, highlighting a direct connection between the gut microbiome and reproductive health. doi.org/hbq9fx

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Surprising and notable if it holds up in humans: Extending ovary function and fertility via gut microbiome (fecal) transplant from young mice to old. estropausal mice

"a direct link between the gut microbiota and ovarian health"

www.nature.com/articles/s43...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

Really cool stuff from @bbparis1984.bsky.social lab

doi.org/10.1038/s435...

“Fish” can be both singular (one individual) and plural (multiple individuals of the same species.) “Fishes” is multiple species.

🐠 Fish

🐠🐠🐠 Fish

🐠🐡🐟 Fishes

Now you know. And knowing is half the battle.

Another group following up on the work from my PhD, linking LINE-1 transposon expression to aging phenotypes!

Yes! We literally cannot shut up about our work.

Support the Human Ageing Genomic Resources Help Joao Pedro Magalhaes raise money to support University of Birmingham

🚨 The Human Ageing Genomic Resources Are at Risk

For over 20 years, our Human Ageing Genomic Resources (HAGR) have supported ageing and longevity research.

We are raising funds to secure their continuity while we pursue long-term funding.

www.justgiving.com/page/human-a...

Thank you Laura! ❤️

Thank you! 😊

Fecal Transplants Between Older and Younger Female Mice Leads to Unexpected Discovery YouTube video by USC

Video coverage from @uscleonarddavis.bsky.social
www.youtube.com/watch?v=Sv86...

This work supports the idea that ovarian function is plastic and opens research avenues into therapies to prolong ovarian lifespan. We are grateful to our collaborators, the teams of #SarahBooth at Tufts and #PeterMullen at #USC, as well as to #GCRLE for funding. @uscleonarddavis.bsky.social 11/11

Together, our work shows that the aged female gut microbiota can promote ovarian health in young recipients (including decreased inflammation and increased fertility), which we hypothesize is due to compensatory signaling in the bidirectional ovarian-gut microbiome communication. 10/11

Finally, #mediation analysis identified potential microbial species mediating the effect of heterochronic #FMT on #ovarian health. 9/11

Analyses of the transplanted microbiome and serum metabolites in #FMT recipients 💩 revealed that (i) the microbiome was lastingly remodeled, and (ii) that several interesting pathways had been remodeled in post-estropausal #FMT recipients, including VitK and NAD metabolism. 8/11

Consistent with transcriptomics 🧬 results, we observed overall improved ovarian health (based on follicle counts & serum AMH/FSH/INHA levels), as well as shorter time to pregnancy for post-estropausal #FMT recipient mice 🐁, suggesting that aged #FMT functionally rejuvenated recipient ovaries. 7/11

Consistent with decreased inflammation, comparison to known #aging and #senescence gene signatures by GSEA showed a significant decrease in expression of such signatures, suggesting partial molecular #rejuvenation of the ovarian tissue in response to the post-estropausal #FMT. 🚨 6/11

Surprisingly, mice that received estropausal #FMT showed trends for decreased inflammation of the ovarian tissue at the transcriptional level, as well as the protein level for pro-inflammatory IL6 staining in ovarian tissue. 5/11

Thus, we decided to perform #FMT from aged and old female mice into young female ♀️mouse recipients 🐁. Interestingly, we observed dramatic remodeling of the ovarian transcriptome in response to #FMT. 4/11

Importantly, the #female ♀️ mouse 🐁 gut microbiome showed large-scale remodeling with aging, including a surprising increase in microbial diversity (in contrast to the male aging gut microbiome). 3/11

Art by Dr. Rapheal Williams representing the gut microbiome/ovarian axis with aging.

When we were starting this study, there was already data supporting lifelong gut/ovary communication, and, based on previous #FMT work showing deleterious effects of #heterochronic #FMT on the 🧠, Minhoo reasoned that aged, post-estropausal #FMT 💩 should damage youthful ovarian function. 2/11

Excited to share our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by Dr. #MinhooKim, published online today at @nataging.nature.com, where we describe surprising findings on the gut/ovary axis. 🧪🖥️🧬. A 🧵1/11 www.nature.com/articles/s43...

🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

March is #Endometriosis Awareness Month, and this Editorial by Alex Tosun (@atosun.bsky.social) discusses why greater awareness, education, funding and research for this systemic condition is imperative to redefining pain, equity, and investment in women’s health 🧪🌻 #Medsky
plos.io/4slvscE

Very excited to organize the 2026 FASEB Conference: Chromatin and Epigenetics in Aging and Disease with Ashby Morrison, @bbparis1984.bsky.social , and Ernesto Guccione! Join us in Ireland this fall! Speaker slots are available and trainees are invited to a pre-meeting career development event.

Thanks to the efforts of lab member Mingfei Chen, we are celebrating one year of development of behavioral assays in the #killifish 🐠 🐟 today! 🎊🎊🎊 🔬🥼🧪👩‍🔬👨‍🔬

@biorxivpreprint.bsky.social Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans
www.biorxiv.org/content/10.6... @bloodgenes.bsky.social @jswlab.bsky.social @bostonchildrens.bsky.social @hhmi-science.bsky.social @broadinstitute.org

Registration is open for the 2026 @faseborg.bsky.social "Chromatin and Epigenetics in Aging and Disease" conference, which will take place in Malahide, Ireland, organized by @aewebb.bsky.social and Ashby Morrison. Join us this Fall: events.faseb.org/event/41ac15...