BrenneisenLab

Thrilled to share our newest publication in Materials & Design doi.org/10.1016/j.ma...: combinational treatment of the antimalarial drug chloroquine and nanoceria has a selective cytotoxicity on triple negative breast cancer (TNBC) cells in a 2D and 3D cell culture system. To all authors: well done

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Immune evasion through mitochondrial transfer in the tumour microenvironmenthttps://

www.nature.com/articles/s41586-024-08439-0

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk betw... Abstract. Cannabidiol (CBD), a major nonpsychoactive constituent of cannabis, is considered an antineoplastic agent on the basis of its in vitro and in vivo activity against tumor cells. However, the ...

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
aacrjournals.org/mct/article/...

Wish all followers and members of bluesky 🦋 a Happy New Year and all the best in 2025 🍀🖖

Are cancer survivors less likely to develop Alzheimer’s? Research shows that patients with a history of cancer are less likely to develop dementia and those with Alzheimer’s are less likely to develop cancer

People with a history of #cancer are less likely to develop #dementia and those with #Alzheimer are less likely to develop cancer. Understanding this relationship, say scientists, could lead to new treatments.
Really enjoyed writing my first piece for The Observer
www.theguardian.com/science/2024...

From TheObserver: Are cancer survivors less likely to develop Alzheimer’s?
That’s interesting 🤔

What is common to almost all tumor types 🤔? A significant increase in the amount of reactive oxygen species (ROS) compared to normal (healthy) cells 👍. Let‘s target that for anticancer therapy? Is that possible? Will see …. .

The chalcone cardamonin (CD) has a similar selective effect on tumor cells in context of cell viability as the cerium oxide nanoparticles 😀 - a promising tool for cancer therapy 🤔?
doi.org/10.3390/anti...
doi.org/10.1016/j.ti...
doi.org/10.1371/jour...

Cerium oxide nanoparticles (CNP, nanoceria) selectively kill tumor cells without affecting normal (healthy) cells
doi.org/10.1371/jour...
doi.org/10.1371/jour...
doi.org/10.3390/anti...
doi.org/10.1016/j.re...
doi.org/10.1158/1535...
doi.org/10.1089/ars....
doi.org/10.1016/j.bi...

Nanoparticles (cerium oxide) and natural compounds such as cardamonin, gossypol or artesunate (often in combination with chemotherapeutics) selectively modulate mitochondrial function and the amount of reactive oxygen species in tumor cells. Have a look on our publications in PubMed bit.ly/3ZWNZR5