Dan Diekema's Avatar

Dan Diekema

@dandiekema

Infectious diseases physician, epidemiologist, and clinical microbiologist. University of Iowa to Maine Medical Center-MaineHealth. Views are my own

2,173
Followers
1,555
Following
34
Posts
09.11.2024
Joined
Posts Following

Latest posts by Dan Diekema @dandiekema

There have already been two games this WBC where a team hit 4+ home runs

The only WBC with more such games was 2009 (4)

07.03.2026 17:46 πŸ‘ 32 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Post image

IDSA President Ronald Nahass, MD, MHCM, FIDSA, President-Elect Wendy Armstrong, MD, FIDSA and Misha Huang, MD met with @degette.house.gov.

Thank you, Rep. DeGette, for meeting with us to discuss the ID workforce and support for public health, ID research and outbreak preparedness!

06.03.2026 20:59 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Post image

Nearly 80% of U.S. counties lack an ID physician. Thank you to the office of Sen. Susan Collins for meeting with us to discuss the value of ID care.

06.03.2026 15:17 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Preview
FDA’s controversial vaccine chief will exit agency next month | CNN The US Food and Drug Administration’s head of vaccines and biologic medicines will leave the agency at the end of April, a spokesperson confirmed to CNN on Friday.

Vinay Prasad has been an a noxious influence on public health and drug regulation. Good riddance. UCSF should not take him back. He should wander in the wilderness forever. www.cnn.com/2026/03/06/h...

06.03.2026 23:39 πŸ‘ 929 πŸ” 230 πŸ’¬ 33 πŸ“Œ 19
Post image

Thank you to the office of @peters.senate.gov for hearing why strong public health funding, more ID physicians, and research support matter for patients and communities. πŸ’—

06.03.2026 15:20 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Post image

Thank you to the office of @pingree.house.gov for meeting with our members @kinnathakarar.bsky.social and Lisa Chirch, MD, FIDSA, and IDSA associate director of advocacy Rabita Aziz, to discuss how we can keep patients and communities safe! πŸ’—

06.03.2026 15:07 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Post image Post image

My most unconventional view is that I think people who wrote stuff like this hold a sliver of blame for the loss of public trust.

02.03.2026 16:19 πŸ‘ 11 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Post image

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

01.03.2026 15:32 πŸ‘ 1540 πŸ” 438 πŸ’¬ 40 πŸ“Œ 22

Trump says he’s sending a β€œgreat hospital boat” to Greenland to help β€œthe many people who are sick”, but the catch is that the only supplies it is carrying are ivermectin, beef tallow, and pull up bars.

22.02.2026 15:33 πŸ‘ 227 πŸ” 23 πŸ’¬ 32 πŸ“Œ 3

Breaking: The U.S. dispatches health insurance claim denial ship to Greenland.

22.02.2026 13:18 πŸ‘ 700 πŸ” 149 πŸ’¬ 18 πŸ“Œ 9
Post image Post image Post image Post image

New from @cidjournal.bsky.social and Mayo Clinic, a modern cohort of Legionella PNA:

344 adults with Legionella (85% L pneumophila)

1/3rd ICU, 1/8 died at 30 days

Urine Ag only + test in 42.4%, but among those with +PCR/Cx, UAg+ in only 25.6%

#IDSky #Legionella

academic.oup.com/cid/advance-...

22.02.2026 16:34 πŸ‘ 19 πŸ” 6 πŸ’¬ 1 πŸ“Œ 3
Post image

On-demand access is available now from the 52nd Annual Remington Winter Course in ID.

5 days of course lectures are now streaming including the Case Challenges and Panel Discussions.

20 CPD Credits are available.

www.wintercourse.org to register.

#IDSky

21.02.2026 15:29 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Getting shown up in the arena of elite impunity by *the British monarchy* is an incredible β€œAmerica at 250!” achievement

19.02.2026 12:20 πŸ‘ 13439 πŸ” 3448 πŸ’¬ 128 πŸ“Œ 126
Preview
Opinion | The MAHA Coalition Is Falling Apart

Prasad β€œis less an exceptional character than a representative figure in R.F.K.’s MAHA alliance β€” an outsider critic, swept into power on a wave of pandemic backlash, and poorly suited to the work of helping to actually run the public-health establishment rather than merely finding fault with it”

19.02.2026 03:01 πŸ‘ 26 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0
Preview
One Pivotal Trial, the New Default Option for FDA Approval β€” Ending the Two-Trial Dogma | NEJM This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

Why are we still platforming these assholes in the Journal, exactly? www.nejm.org/doi/full/10....

18.02.2026 23:47 πŸ‘ 19 πŸ” 6 πŸ’¬ 2 πŸ“Œ 0
Preview
NIH Director Jay Bhattacharya will take over leadership of CDC temporarily The transition is the latest in a monthslong series of leadership shake-ups across federal health agencies.

NIH Director Jay Bhattacharya is now also the temporary head of the CDC, a role in which he is expected to continue to do nothing but appear on right-wing podcasts and further cement the complete lack of respect of his colleagues.

18.02.2026 19:19 πŸ‘ 298 πŸ” 113 πŸ’¬ 23 πŸ“Œ 11
Post image

4-5 years ago there were MDs like Lucy McBride crowing about the urgency of normal, getting kids back to school. There were PR hacks like David Zweig supporting them. Now kids are being sent to immigration detention, getting measles & these folks are nowhere to be found. It was never about the kids.

18.02.2026 11:25 πŸ‘ 418 πŸ” 122 πŸ’¬ 8 πŸ“Œ 6
Preview
More than a message: Death by a 1,000 β€œChats” Abstract. Secure electronic messaging within the electronic health record (EHR), such as Epic Chat, has transformed communication in hospitals by enabling

Check out our article and guidance on Epic chat messages in CID. Anyone doing frontline clinical work understands the substantial downsides of constant, on-demand, text communication in the EHR. So great to write this with ID fellows. doi.org/10.1093/cid/...

14.02.2026 15:46 πŸ‘ 28 πŸ” 11 πŸ’¬ 1 πŸ“Œ 1
Tweet: That slide is even worse than the NEJM KM curves with the truncated y-axis graph inserted on the proper graph. 

Now show me the curves without massively truncating the y-axis

Thank goodness Vinay is at FDA

Tweet: That slide is even worse than the NEJM KM curves with the truncated y-axis graph inserted on the proper graph. Now show me the curves without massively truncating the y-axis Thank goodness Vinay is at FDA

This is such terrible advice that I should use it to update my example of when stretching your y-axis is misleading, and truncating your y-axis is fine.

Hint: Only a fraction of people in a trial will get infected regardless.

14.02.2026 22:04 πŸ‘ 186 πŸ” 31 πŸ’¬ 17 πŸ“Œ 12
Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets.
Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin Ξ±3Ξ²1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1Ξ± (HIF1Ξ±) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-Ξ²D-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyte–macrophage colony-stimulating factor (GM-CSF) and IFN-Ξ³ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue …

Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets. Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin Ξ±3Ξ²1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1Ξ± (HIF1Ξ±) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-Ξ²D-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyte–macrophage colony-stimulating factor (GM-CSF) and IFN-Ξ³ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue …

Risk factors for Mucormycosis

Risk factors for Mucormycosis

Risk factors for mucormycosis continued

Risk factors for mucormycosis continued

Mucormycosis

Review in @nejm.org by Dimitrios Kontoyiannis and Tom Walsh

www.nejm.org/doi/10.1056/...

#IDSky #TxID #MedMycoSky @msgerc.bsky.social

13.02.2026 18:40 πŸ‘ 26 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
Two adults and two kids in ski helmets and goggles on a snowy mountain

Two adults and two kids in ski helmets and goggles on a snowy mountain

Just back from another excellent @wintercourseid.bsky.social

Highly recommend this meeting, especially for ID fellows and junior faculty. World class faculty, high yield topics, and lots of time to enjoy the πŸ”οΈ #IDSky

13.02.2026 13:07 πŸ‘ 11 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
Post image

52nd Remington Winter Course has been incredible so far! Great networking and camaraderie alongside the ID updates.

Tuesday's sessions and cases are now available on-demand. Wednesday's program will post throughout the day today.

Visit www.wintercourse.org to view.

#IDSky #Medsky

11.02.2026 15:39 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
Post image

Mexico reports more human New World screwworm infections

Mexico has now reported 141 human cases of the parasitic infection, which is spread by flies.

www.cidrap.umn.edu/n...

11.02.2026 22:22 πŸ‘ 26 πŸ” 20 πŸ’¬ 3 πŸ“Œ 2
Post image

Step 1: Insert bacteria ("Wolbachia") into mosquitoes.

Step 2: Release mosquitoes.

Step 3: Watch Dengue rates plummet.

Phenomenal results from Singapore.

Link: tinyurl.com/59c9t67u, by Lim et al.

11.02.2026 23:21 πŸ‘ 77 πŸ” 23 πŸ’¬ 2 πŸ“Œ 2
Post image

Another wonderful #RWCID, great speakers, amazing cases, wonderful camaraderie and even great skiing despite a terrible snow year @wintercourseid.bsky.social

11.02.2026 23:39 πŸ‘ 5 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
Post image

We love mountain meetings but internet connections can be slow. Sunday PM/Monday AM sessions now available to stream for those watching from home

Monday PM w/our amazing ID Case Panel will be posted ASAP.

Thanks for your patience while we caught up!

www.wintercourse.com for access
#IDSky #Medsky

10.02.2026 01:36 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Post image

Don't miss last nights WCID Case Panel now available for streaming!

Great cases from Andy Hale with panelists:

Helen Boucher
Wendy Armstrong
Kim Hanson
Jeanne Marrazzo

www.wintercourse.org

#IDSky #MEDSky

10.02.2026 15:20 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Post image

We are underway!

Welcome to the 2026 Winter Course in Infectious Disease. Our 52nd Annual Conference, can you believe it!

Log in to www.wintercourse.org for access to Dr Marrazzo and our other stellar presentation.

#Idsky

08.02.2026 21:11 πŸ‘ 7 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
Post image

52nd Winter Course in Infectious Disease kicking off soon!

Today's agenda for those watching at home

#IDSky #MedSky

08.02.2026 18:08 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Post image

πŸ”₯Away we go!

52nd Annual Conference ready to get under way with Infectious Diseases Society of America (IDSA) CEO Jeanne Marrazzo, MD, MPH, FIDSA kicking us off!

If you would like to join On-demand please register here:
www.wintercourse.org for access.

#IDSky #Medsky

08.02.2026 18:30 πŸ‘ 8 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0