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Tim Crawford

@timcrawfordnz

Biochemist and life scientist, digging at the intersection of transcription, epigenetics and stress response in photosynthetic organisms. Musician and travelling Kiwi by night.

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10.01.2025
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Latest posts by Tim Crawford @timcrawfordnz

100%. I think I've offended a few biotech friends by saying something to that effect, but it's true.

25.02.2026 08:27 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Not yet, no. I've had to go back to finish some stuff that was already started with ChIP - and oh boy does it feel like a drag now! C&x is vastly superior. We are a plant lab, and ChIPping plant Mediator was at or beyond the limits of ChIP tech. The thing is simply whether or not it works.

20.02.2026 13:52 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

There's a lot of optimisation to be done and it needs to be expanded out of the typical 'human' and 'histone' research area. For example there is no C&x validated GFP antibody! Also no commercially available greenCUT&x enzymes. The tech is in its infancy still but there is massive potential.

20.02.2026 08:03 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

#PlantScienceJobs #PhD

11.02.2026 17:34 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

My hometown ❀️ feel free to message me if you need any inside tips for the best way to spend your (free) time there!

05.02.2026 07:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

CogSci*, even

29.01.2026 08:59 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I don't know the CogDci field but that guy seems like he deserves to be someone's academic hero. But at some point you've got to mature your view of them from hero to respected colleague - around that time you'll be at their level anyway. Osmote their lessons!

29.01.2026 08:33 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Video thumbnail

I am excited to offer a postdoctoral research position in my lab in Oxford studying the distribution of small RNAs during plant sexual reproduction. shorturl.at/7Goxt
Reposts appreciated!
Obligatory cat video to brighten your day. :-)

26.01.2026 16:31 πŸ‘ 157 πŸ” 88 πŸ’¬ 4 πŸ“Œ 5

Is that why they have that structure with a number of junior group leaders / a-profs working under a full Prof?

12.01.2026 07:54 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

That's a beautiful kākāpō. One of only 237 left on the planet.

08.01.2026 12:03 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

They will be. This won't last forever.

07.01.2026 10:59 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congratulations!

09.12.2025 13:37 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Perhaps. Certainly Germany is already relatively good at supporting ECRs, but it could be better, and I can't vouch for other European countries. Flagship ideas might have better PR optics but I think increasing early stage funding would improve the foundation for the science community overall.

03.12.2025 18:02 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Another example of rich-get-richer. We didn't need big money to support (or attract to the EU) the big boys who already have it. We needed more low-level seed or supporting funds for ECRs/ scientists who are struggling to keep their employees paid.

03.12.2025 15:20 πŸ‘ 22 πŸ” 1 πŸ’¬ 1 πŸ“Œ 1

The last one nailed it. But really not much has changed in ten years. Just exacerbated existing problems

29.11.2025 08:59 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Conserved heat shock factors HvHSFA2 and HvHSFA3 control barley heat stress memory through diverged mechanisms - Nature Communications Here the authors show that two conserved transcription factors are required for heat stress memory in barley by mediating proper induction of heat-response genes after recurring heat stress. Overexpre...

More new research from the BΓ€urle lab: we extend our understanding of heat-stress memory into monocots! Spoiler alert: it's a bit different to Arabidopsis!

www.nature.com/articles/s41...

23.11.2025 13:18 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Promoter and domain swap analysis delineates heat stress memory-specific determinants of heat shock factor HSFA2 The function of the transcription factor HSFA2 in heat-stress induced transcriptional memory maps to functional domains within the protein.

Latest research from the BΓ€urle lab on the function of our favourite memory TF - HSFA2!

16.11.2025 08:57 πŸ‘ 11 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0

Absolutely it's real. My dad used to catch guys like these all the time. It's a big one for sure!

10.11.2025 14:35 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhan...

this looks very interesting with numerous implications for nuclear biology and gene expression.

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...

09.11.2025 17:07 πŸ‘ 27 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0

Terrifying if you're not expecting it though!

29.10.2025 15:18 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Shouldn't there be a clear conflict-of-interest statement on this article?

17.10.2025 05:32 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Would very much like to! My boss is one of the keynotes, I'm trying to convince her.

16.10.2025 16:36 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Are you going to this @tamara-hverdeja.bsky.social ?

16.10.2025 16:25 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Great interview Tamara. I also miss those calm, quiet, snowy nights in the deep of winter in UmeΓ₯!

11.10.2025 19:39 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Ironically enough, your response here has a cadence reminiscent of ChatGPT...

18.09.2025 08:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congratulations! Both papers look super interesting. We will have to take some of the latter paper into account when dealing with our heat 'stress' assays

25.08.2025 07:22 πŸ‘ 2 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

And yes we have sugar in our plates πŸ˜† apparently memory doesn't operate without it, although we haven't looked at this.

25.08.2025 17:12 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I believe our lab did some experiments on (memory) gene expression in dissected seedlings (before my time). Memory was supposedly organ-autonomous, with photosynthetic tissues displaying the largest response. But that was just targeted analysis/qPCR, afaik we haven't done it transcriptome-wide

25.08.2025 17:10 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Congratulations! Both papers look super interesting. We will have to take some of the latter paper into account when dealing with our heat 'stress' assays

25.08.2025 07:22 πŸ‘ 2 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

Hi Kelsey! I'm interested, but I have some questions, I'll send you a message.

29.07.2025 08:44 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0