Louise Reilly, PhD

New study from Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/...

#IonChannels

Check out our most recent publication on functional assessment of Kir2.1 clinical variants 🧪
doi.org/10.1016/j.jb...

Celebrating 10 years of great science and friendship between labs Eckhardt and Glukhov 🧪

This is a great graphic: all of the studies with a dot in the corner were conducted by the Geiers -- one of whom, David Geier, practiced medicine without a license

Thanks. Also FYI this was Berg's post I had meant to share. $270mm difference is still equivalent to ~400 new R01's, so not trivial.

But in general surprised me that the difference was relatively small (only 6.5% less funding for new and competitive renewals than in 2024).

bsky.app/profile/jere...

Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes - Scientific Reports Scientific Reports - Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes

Our most recent publication detailing the impact of arrhythmogenic KCNJ2 mutations on channel structure 🧪

@nature.com

www.nature.com/articles/s41...

🚨ATTENTION CDC AND ALLIES!🚨
We have power together. To see our strength and build community, we ask that you wear something 💚green💚 to work this WEDNESDAY to show solidarity and readiness to defend public health.
Please spread the word!
#courageiscontagious #wearthecolor #spreadthecolor

This month is Heart Month! Professor Will Fuller explains what his research is about.

Will Fuller’s research group works on cellular and molecular mechanisms that control normal physiology in the heart, and how these things stop working properly to cause disease. (1/4)

Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels pubmed.ncbi.nlm.nih.gov/40074079/ #cryoEM

A single neuron (white) shown with 5,600 of the axons (blue) that connect to it. The synapses that make these connections are shown in green. The cell body (central core) of the neuron is about 14 micrometers across.

In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/3FvpAKy #BrainAwarenessWeek

This is a fantastic meeting for people interested in lipid post translational modifications!

So glad this meeting is still going strong!!

a man in a red suit and tie is holding a piece of paper that says breaking news on it ALT: a man in a red suit and tie is holding a piece of paper that says breaking news on it

Some good-ish news from NIH

“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”

As far as I know, the timing for this is not clear, but I will be checking the Federal Register.

"‘Science can and should as a community organise itself to maximise its ability to act collectively, ethically and – when necessary – politically.’ The scientific community needs to speak up – not just for the sake of science, but of human decency, dignity and morality." - @philipcball.bsky.social.🧪

Image of science impacts in one month of Trump 2.0. Timeline screenshoot from Nature.com article linked in post.

A breakdown of what's happened so far to #Science in the US. Truly horrifying 🧪

www.nature.com/articles/d41...

BPS2025 Black in Biophysics Symposium | Biophysical Society The Biophysical Society has been a change agent for members of groups historically underrepresented in the physical and life sciences, women, and international scientists. We serve all members and…

Black in Biophysics symposium today at the 69th Annual Meeting highlights Black scientists and honor Black History Month in the United States and elsewhere #bps2025

a man wearing a top hat and a purple jacket is asking for more . ALT: a man wearing a top hat and a purple jacket is asking for more .

ATTENTION

If you are on a study section that was scheduled to meet, please post or DM me with information regarding:

1. The name of the study section

2. The scheduled date

3. Whether the meeting actually occurred

THANK YOU

It’s been buried in all the news today, but every scientist in the US should pay attention to this:

Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪

From the labrats community on Reddit Explore this post and more from the labrats community

From reddit: a letter from a postdoc who survived the Bolsonaro years. This is helpful framing for how to science in this administration. 🧪

www.reddit.com/r/labrats/s/...

Image depicts a tv screen showing a slide presentation with an acknowledgment slide.

Thanks to @ucd-physiology.bsky.social @elegrand.bsky.social @morottilab.bsky.social for allowing us to attend the UC Davis Cardiovascular Symposium! Our lab was able to watch our incredible PI, Lee Eckhardt, give you all an insight into the work we do up in Wisconsin! 🧪

Additionally, Dems had the opportunity to stall and they didn't. Once again they ceded to GOP

RFK Jr was confirmed.
There is a lesson here for the future.

The only chance that science had to stop RFK was a public relations strategy—to mobilize enough of the public that people not paying attention to politics would learn that he is a disaster. We failed at that. Let’s fix it and do better. 🧪

BREAKING: NIH admits funding freeze is illegal, will resume issuing grants An internal memo issued February 12 was obtained by Popular Information.

BREAKING

On Monday, Popular Information broke the news that the NIH had frozen virtually all grant funding in violation of 2 federal court orders

On Wednesday, NIH leadership distributed a memo, acknowledging that its funding freeze was illegal and directing staff to resume issuing grants.

Breakdown of the costs of research by direct/indirect costs.

Here's a good infographic from AAUP on what indirect costs fund. It's a lot of important things!

98% of NIH grants that should have gone out this month, didn't. Despite court orders 'unfreezing' the funds, they are frozen. Biomedical research will grind to a halt. Clinical trials will end. All for no reason: the total impact on the US budget is miniscule

a man in a suit and tie says go for it in white letters ALT: a man in a suit and tie says go for it in white letters

The no cost extension button is back and at least some are being granted. If this applies to you, go for it.

PLEASE SHARE

The Grant Cycle
**My new book comes out next week, pre-order now: bit.ly/OOYM

Comics Help Jurors Understand Forensic Testimony, New Study Finds Comics could be the answer to clarifying forensic testimony for jurors—here's why.

Forensics: Comic books. Somewhat funny tactic to teach juries about science. Those of us who testify as experts talk too fast and use fancy tech words and archaic language. 🧪

www.forbes.com/sites/larsda...

Trump maintains funding freeze at NIH, defying court order The Trump administration is still prohibiting National Institutes of Health (NIH) staff from issuing virtually all grant funding, an NIH official tells Popular Information.

Not sure how many realize that NIH funding is still frozen. This article details an almost complete dropoff (97%) in NIH funding between Feb3-10 this year and last. Our institution's numbers are consistent with those cited here. If yours are as well, please share!
popular.info/p/trump-main...

This is outstanding! Watch it and share...