In 75-79 year olds in UK, the RSV Pre-F vaccine remains highly effective in the real world. 82.3% vaccine effectiveness against hospitalization due to RSV-associated acute respiratory infection and 86.7% effectiveness against severe disease requiring oxygen
www.thelancet.com/journals/lan...
Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...
The wwPDB just hit a major milestone: 𝟏𝟎,𝟎𝟎𝟎 𝐄𝐌𝐃𝐁 𝐞𝐧𝐭𝐫𝐢𝐞𝐬 𝐫𝐞𝐥𝐞𝐚𝐬𝐞𝐝 𝐢𝐧 𝐚 𝐬𝐢𝐧𝐠𝐥𝐞 𝐲𝐞𝐚𝐫. To put this in context, the entire EMDB reached 10,000 entries total in 2019 — now the archive 𝐡𝐚𝐬 𝐬𝐮𝐫𝐩𝐚𝐬𝐬𝐞𝐝 𝟓𝟎,𝟎𝟎𝟎. Huge credit to the community driving 3DEM forward!
www.wwpdb.org/news/news?ye...
#3DEM #EMDB
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen pubmed.ncbi.nlm.nih.gov/41484092/ #cryoEM
De novo design of protein nanoparticles with integrated functional motifs www.biorxiv.org/content/10.64898/2025.12.19.695620v1 #cryoEM
An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoEM
How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬
Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉
www.biorxiv.org/content/10.6...
CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!
This is an interesting case of a patient from Chad infected with a novel arenavirus species/variant/strain, presenting with meningoencephalitis.
IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed).
www.nejm.org/doi/10.1056/...
Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody!
Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social
@hhmi.org
www.nature.com/articles/s41...
🧪 🦠 Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B www.nature.com/articles/s41...
Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action pubmed.ncbi.nlm.nih.gov/41184282/ #cryoEM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Structural Mechanism of Prestin-Membrane Mechanotransduction https://www.biorxiv.org/content/10.1101/2025.10.31.685930v1
HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor pubmed.ncbi.nlm.nih.gov/41168429/ #cryoEM
Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another https://www.biorxiv.org/content/10.1101/2025.10.26.684670v1
Development of a cross-protective common cold coronavirus vaccine journals.asm.org/doi/10.1128/...
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
journals.plos.org/plospathogen...
Applying computational design, researchers in #ScienceTranslationalMedicine present an integrated vaccine platform that combines the strengths of mRNA and nanoparticle technologies, and show it elicits strong immune responses in a SARS-CoV-2 model system. https://scim.ag/3W9M09p
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity!
www.biorxiv.org/content/10.1101/2025.09.03.673949v1
Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...
New preprint! If some merbecoviruses use DPP4 and others use ACE2, what do those hedgehog merbecoviruses use?! As it turns out, neither! In our latest study, we uncover the "missing" receptor for the MERS-related viruses in hedgehogs. [These findings were first shared at ASV this year] (1/6)
Characterization of the glycoproteins of fish and amphibian influenza B–like viruses www.science.org/doi/10.1126/...
Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope pubmed.ncbi.nlm.nih.gov/40830099/ #cryoEM
Our aim was to create a kit to produce in-house 1.2 holey carbon cryoEM grids, in three simple steps, at less than half of the prize, and without due times. I think we are there. Academic teams that want to know more, receive training or order a kit, please contact grids@puxano.com.
The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody www.cell.com/structure/fu...
Molecular organization of the New World arenavirus spike glycoprotein complex | @natmicrobiol.nature.com
www.nature.com/articles/s41...
Discovery: mRNA vaccine candidate blocks malaria from reproducing inside mosquitoes, cuts transmission by up to 99.7%. Built on cryo-EM insights into parasite’s fertilisation machinery. A key step towards elimination. In @science.org
🔗 www.wehi.edu.au/news/reveale...
