Huge thanks to @fredericauvray.bsky.social, Mathieu Epardaud, @ericoswald.bsky.social and @priscillabranchu.bsky.social for your valuable contributions and collaboration on this work! 👏

#OMVs #OuterMembraneVesicles #Vaccines #Microbiology #JEV

We discuss OMVs’ intrinsic immunostimulatory properties and genetic engineering strategies to enhance their yield and antigen presentation. We also address key challenges in large-scale production and stability, and explore their applications against bacterial pathogens, viruses, and even cancer.

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram-negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory ...

🚨I'm happy to share our latest review on outer membrane vesicles (OMVs) as a promising platform for vaccine development in the Journal of Extracellular Vesicles. 💉

🔗 Read it here: isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

Thank you so much Priscilla and @fredericauvray.bsky.social for your invaluable guidance and I’m so glad to share this achievement with you! 🌟

I also want to sincerely thank the amazing team who contributed to this project: @priscillabranchu.bsky.social, @fredericauvray.bsky.social, Cecile Goursat, @audrey-goman.bsky.social, Patricia Martin, @jpnoug.bsky.social and Eric Oswald 🌟

Development of intimin-enriched outer membrane vesicles (OMVs) as a vaccine to control intestinal carriage of Enterohemorrhagic Escherichia coli Enterohemorrhagic Escherichia coli (EHEC) are foodborne pathogens causing severe human infections including hemorrhagic colitis and hemolytic uremic s…

I'm thrilled to share our work on the development of a new type of vaccine based on Outer Membrane Vesicles enriched with intimin to control intestinal carriage of Enterohemorrhagic Escherichia coli 🦠💉
www.sciencedirect.com/science/arti...