Wouter Droogers

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons - Nature Communications It is unclear how new lysosomal proteins are properly delivered in polarized neurons. Here, the authors developed a method combining the synchronization of protein release from the endoplasmic reticul...

www.nature.com/articles/s41...

POTATOMap is officially out today! (Even tho it says 2024Dec30… yeah long story😂)

Thank you to all the authors and everyone involved! I hope we have provided something useful and maybe leave a little (just a little) impact in your research.

Great to see our work published! I'm glad I was able to contribute during my time in Montréal.

Excitatory synapses onto Basket cells show anti-Hebbian plasticity following supralinear calcium signalling.

Principles of visual cortex excitatory microcircuit organization Synapse-specific connectivity and dynamics determine microcircuit function but are challenging to explore with classic paired recordings due to their low throughput. We therefore implemented optomapping, a ∼100-fold faster two-photon optogenetic method. In mouse primary visual cortex (V1), we optomapped 30,454 candidate inputs to reveal 1,790 excitatory inputs to pyramidal, basket, and Martinotti cells. Across these cell types, log-normal distribution of synaptic efficacies emerged as a principle.

I am delighted to highlight our recent publication in The Innovation — @theinnovation.bsky.social — titled “Principles of visual cortex excitatory microcircuit organization”, where we showcase optomapping, ie 2p optogenetic circuit mapping! www.cell.com/the-innovati...

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

E11 Bio Roadmap | E11 Bio

"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmap

Thank you for this great list! Would love to be added as well😀

Could you add me? Great list of people!

Great list! Would love to be added!

Would love to be added to this great group!

I'd be honoured if you could add me!

ORANGE (CAKE)! CRISPR in neurons😃

Awesome! Would be great if you could add me!

Hey there! Just moved away from the former bird app. And I'm excited to announce that I recently started a postdoc at Radboud University with Anne-Sophie Hafner! We will use proteomics and spatial transcriptomics to investigate episodic memory during development