Daphne Superville

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding @nature.com @danafarber.bsky.social @harvardmed.bsky.social @judithagudo.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...

@biorxivpreprint.bsky.social PTPN1/2 inhibits alveolar macrophage-mediated control of lung metastasis
www.biorxiv.org/content/10.6...

A disease model resource reveals core principles of tissue-specific cancer evolution - Nature The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

new out in Nature www.nature.com/articles/s41...

Automated discernment of prognostic spatial features of #TNBC specific to cell interactions at the tumor border or metastatic site @natcancer.nature.com @noahgreenwald.bsky.social @joleneranek.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...

Insights: Frosio and Ostuni @unisr.bsky.social discuss new study by Gorin et al. (rupress.org/jem/article/...) which reveals an unexpected mechanism by which IFN-γ sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface. rupress.org/jem/article/...

Modeling the evolutionary dynamics of clonal hematopoiesis @natgenet.nature.com @moffittnews.bsky.social
www.nature.com/articles/s41...

Systemic hypoxia suppresses solid tumor growth Local hypoxia is a hallmark of solid tumors and a negative prognostic factor in the progression and treatment of cancer. Here, we showed that systemic hypoxia, in contrast to localized tumor hypoxia, decreases tumor growth in vivo across multiple cancer...

🚨 NEW 🚨 "Systemic hypoxia suppresses solid tumor growth"

@ayushmidha.bsky.social
@genophoria.bsky.social
@ishahjain.bsky.social
@arcinstitute.bsky.social
@ucsfhealth.bsky.social

https://bit.ly/4arkFX8

Cool to see data backing up an anecdote I have been told - that short (1 hour) formaldehyde fixation can be better than longer (6 hours+) fixation for staining some antigens:

Intracellular bacteria in cancer cells promote immunosuppression in the metastatic niche Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01279-1Intracellular bacteria in cancer cells promote the recruitment of neutrophils and their polarization towards an immunosuppressive phenotype via a cGAS-STING-dependent pathway.

Intracellular bacteria in cancer cells promote immunosuppression in the metastatic niche

Matrix-bound nanovesicles elicit epigenetic changes in myeloid cells, modulating their response to future inflammatory events
www.science.org/doi/10.1126/...

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis @cp-cellchembiol.bsky.social @danafarber.bsky.social
www.cell.com/cell-chemica...

IFN-γ-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals @insight.jci.org @tcddublin.bsky.social
insight.jci.org/articles/vie...

CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response CLIM-TIME provides a high-throughput perturbation-mapping platform that links tumor suppressor gene loss to spatially defined metastatic niches and immune responses, identifying LOXL2 as a key modulator of suppressive metastatic environments. Inhibition of LOXL2 restores T cell infiltration into tumors and improves the efficacy of therapy.

Now online! CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response

Chrysanthi Moschandrea and I have developed a new conceptual framework for understanding the role of metabolism in cancer, which we term metabolic permissiveness. We are eager to hear your thoughts on this topic.

genesdev.cshlp.org/content/earl...

Targeting Myc activates a tissue-specific tumour resolution programme https://www.biorxiv.org/content/10.64898/2026.02.06.704498v1

Two doses of Recombinant zoster vaccine reduces dementia risk 51% lower risk of dementia (in females > males) even accounting for healthy vacinee bias versus Tdap @natcomms.nature.com
www.nature.com/articles/s41...

S1PR1 signaling biases neutrophils toward long-lived low-inflammatory functional states https://www.biorxiv.org/content/10.64898/2026.02.05.703783v1

Some of the latest work from our lab from outstanding scientist Sensen Lin @ctbatucsf.bsky.social @ucsfcancer.bsky.social

We find MYC- driven #livercancer are dependent on methionine metabolism. This includes a dependence on the ribosomal rRNA methyltransferase NOP2 that is a MYC target. 🧪

Babesia microti (purple) parasites preparing to invade a red blood cell (red) coated in fibrin (yellow). CREDIT: Amy Apgar

Red blood cells typically don’t move independently, but 1% of those infected by the protozoan parasite Babesia microti show clear directional movement, possibly allowing the parasite to move through the blood and infect new red blood cells. In PNAS: https://ow.ly/L96h50Y9uTK

Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment In the triple-negative breast cancer ecosystem, sensory neurons activate cancer-associated fibroblasts to secrete collagen, thus stimulating a dense extracellular matrix that drives immune exclusion.

Now online! Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment

In a preclinical breast cancer metastasis model, the same bacteria strain, when present intracellularly versus extracellularly, exerts opposing effects on tumor immunity by inducing divergent neutrophil states @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Inferring cancer type-specific patterns of metastatic spread using Metient - Nature Methods Metient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories.

In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data.

www.nature.com/articles/s41...

Metastasis gets a little help from immune cell mitochondria @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer https://www.biorxiv.org/content/10.64898/2026.01.31.701004v1

Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis. https://www.biorxiv.org/content/10.64898/2026.01.28.702329v1

Population-scale sequencing resolves determinants of persistent EBV DNA - Nature Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.

Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social

www.nature.com/articles/s41...

RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...

Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.

Transcriptomic Plasticity is a Hallmark of Metastatic Pancreatic Cancer - PubMed Metastasis is the leading cause of cancer deaths. To develop strategies for intercepting metastatic progression, a better understanding of how tumor cells adapt to vastly different organ contexts is needed. To investigate this question, a single-cell transcriptomic atlas of primary tumor and diverse …

Transcriptomic Plasticity is a Hallmark of Metastatic Pancreatic Cancer, by Christine Iacobuzio-Donahue, @danapeer.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/41379552/
introduces a new single-cell method named PICASSO: Phylogenetic Inference of CNA in Single-cell RNA [...]
github.com/dpeerlab/pic...

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth Tumor-associated macrophages (TAMs), which commonly express FOLR2 or TREM2, are enriched in solid tumors and keep the tumor microenvironment (TME) imm…

I am thrilled to announce that our latest paper is out now in @cp-cancercell.bsky.social! 1/n www.sciencedirect.com/science/arti...