Just published my review of neuroscience in 2025, on The Spike.
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
Very useful work for the community that study neuromodulation!
Really proud and excited to share the final version of our paper, co-led by the Bluesky-less Munib Hasnain!!
We asked whether cognitive and motor neural dynamics can be isolated from one another, or whether theyโre driven by common neural mechanisms 1/n
www.nature.com/articles/s41...
Hi, what did you use for extracellular matrix and why does it seem to be localized to L2/3?
The #habenula in our brain tells us about the negative consequences of our actions, helping us avoid risky behaviors and problems with #addiction. My colleagues found neural pathways to the habenula that promoted consistency in the behavior of mice making risky or safe choices.
rdcu.be/d7g8d
Great start of the new year!
A new manuscript just published showing yet again how design principles and strategies from biological perceptive systems enable robust processing on analog #neuromorphic electronic systems, despite their variability!
rdcu.be/d5o0d
Cutting it a bit fine, but hereโs my review of the year in neuroscience for 2024
The eighth of these, would you believe? Weโve got dark neurons, tiny monkeys, the most complete brain wiring diagram ever constructed, and much moreโฆ
Published on The Spike
Enjoy!
medium.com/the-spike/20...
GSK3ฮฒ phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments
www.pnas.org/doi/10.1073/...
Fantastic journey through the history of hippocampal extra cellular recording techniques and the search for cell assemblies by Bruce McNaughton.
onlinelibrary.wiley.com/doi/10.1002/...
๐ง๐ต๐ฒ ๐ฐ๐น๐ฎ๐๐๐๐ฟ๐๐บ ๐ฎ๐ป๐ฑ ๐๐๐ป๐ฐ๐ต๐ฟ๐ผ๐ป๐ถ๐๐ฒ๐ฑ ๐ฏ๐ฟ๐ฎ๐ถ๐ป ๐๐๐ฎ๐๐ฒ๐
This is looking like a must read!
doi.org/10.1016/j.ti...
#neuroscience
Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beatingโฆ ๐งต
Together with some friends we built an optical Brain Machine Interface to see if cortical activity (PPC) can control behaviour in real time, without animals having to learn to use it. Here's what happened:
www.biorxiv.org/content/10.1...
๐ต blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social
1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions
doi.org/10.1038/s415...
The main output of the hippocampus is subcortical.
Today, for the last class on the neurophys of navigation & mem, we will discuss this fantastic paper by @davidtingley.bsky.social (Buzsaki Lab) showing a link btw hippocampal sharp wave-ripples & glucose release.
www.nature.com/articles/s41...
1/n
Thrilled that our paper on the role of the rat prelimbic cortex (PLC) in decision making is finally out! Three main findings are described in this thread
Co-authors: Jensen Palmer, Samantha White, and Kevin Chavez Lopez
doi.org/10.1523/JNEU...
Heard this argument before and about so many brain regions. Agree with insula, but also claustrum, locus coeruleus, basal ganglia (direct/indirect pathways) and cortico-thalamic connectivity are amazing.
