Jorge García

tidyverse on the streets, base r in the sheets

Have you ever wondered how many archaic populations contributed DNA to modern humans? We know about Neanderthals and Denisovans, but the fossil and genetic evidence suggests a much more complex history!

www.biorxiv.org/content/10.6...

We hoped this would take 5 years, but in fact it took 14! Thanks to all co-authors, but particularly Mark Jobling who held it all together, and more. A proper magnum opus. Hope it is useful for those in the field or adjacent. Phew.

New preprint! with @a-solernunez.bsky.social

Rethinking a textbook example of human adaptation "AMY1 copy number evolution in light of demographic history"

Once population structure is accounted for, the classic starch–agriculture narrative becomes much less clear

www.biorxiv.org/content/10.6...

🧬 Avui ha tingut lloc l'acte inaugural del "25è aniversari de la publicació del Genoma Humà", amb la xerrada de l'investigador Tim Hubbard i la taula rodona amb els investigadors Pep Abril, Roderic Guigó i Gemma Marfany, sobre la contribució catalana a la recerca del genoma #25APGH

In #GENETICS, Jacob Marsh, Sachin Kaushik, and @johriparul.bsky.social examine why and when rescaling of forward simulations in population genetics is not accurate, identifying pitfalls in simulation methods. buff.ly/wpzDRV9

Davis Summer Population Genomics Program Want to learn population genetics? Please fill out this form to indicate your potential interest in a 2-week intensive online summer population genetics course taught by Jeffrey Ross-Ibarra and Graham...

Fun news! @gcbias.bsky.social and I are teaching a 2-week online population genetics workshop this summer to raise money for the Center for Population Biology at UC Davis. We're trying to gauge interest -- please fill this out if you might be interested! And please share broadly!

Why did consciousness evolve at all? A superb special issue of @royalsocietypublishing.org brings together experts across disciplines to explore the functions of consciousness and why it emerged in some species but not others. @tecumsehfitch.bsky.social royalsocietypublishing.org/rstb/issue/3...

Excited and proud 😊 to share the final chapter of @hjorvik.bsky.social 's PhD thesis:

Seven Millennia of Human Exploitation drove genomic Changes in Iberian Sheep

Comments welcome! 🧬🧪🏺🐑

www.biorxiv.org/content/10.6...

🧵(1/8)

Assessing Ancient DNA Sampling Strategies for Natural Selection Inference in Humans Using Allele Frequency Time Series Data Abstract. The increased availability of genomic data from ancient humans allows estimating the strength of natural selection at a given locus using time se

Interested in using aDNA time-series datasets to estimate selection?

Our study "Assessing Ancient DNA Sampling Strategies for Natural Selection Inference in Humans Using Allele Frequency Time Series Data" is now out in GBE! doi.org/10.1093/gbe/... @genomebiolevol.bsky.social @cegamorim.bsky.social

We hope this little guide and review of the recent literature on SVs will be useful for the community in #ecology #evolution #genomics #PopGen.

Great lead by Kat!!

📣 The @scilifelab.se #ddls postdoc (2yrs) offers a great community + training + all social benefits!

Happy to discuss your own project ideas! I also have some ideas on ARGs, pangenomes or biobank-scale datasets 🧬🐏🧪🖥️

Deadline is Mar 31 but some admin things need to be handled well in advance!

Biomedical and life science articles by female researchers spend longer under review Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...

Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky

journals.plos.org/plosbiology/...

Linkage disequilibrium scaling improves robustness and power to detect genomic regions under selection. https://www.biorxiv.org/content/10.64898/2026.01.19.700334v1

A hex sticker with a text that reads Hello Data Science with green, yellow and pink scatterplot points in the background. There is a web address www.hellodata.science

📖 Big news! We just released the first five chapters of our new book, Hello Data Science. It is a fully open-access resource written for beginners. Please help us spread the word! A few points about the book are below 👇

🔗 www.hellodata.science

#rstats #datascience #tidyverse

DDLS Research School Postdoc call 2026 Call for Academic and Industrial Postdoctoral Fellowships in Data-Driven Life Science 2026 Generic Description of the DDLS Postdoc Program The SciLifeLab and Wallenberg National Program for Data-Drive...

SciLifeLab has opened a call for #postdoc fellows in Data-Driven Life Science. We would be happy to host such fellows!

Get in touch if you are interested in applying with a project on the evolution of humans and domestic animals using ancient and/or modern DNA 🧪🏺

www.scilifelab.se/data-driven/...

Characterising the detectable and invisible fractions of genomic loci under balancing selection https://www.biorxiv.org/content/10.64898/2026.01.13.698512v1

Postdoc position call @univie.ac.at - happy to host projects related to introgression, great ape genomics, and more!
careers.univie.ac.at/en/postdoc/e...

Global patterns of natural selection inferred using ancient DNA https://www.biorxiv.org/content/10.64898/2026.01.07.697984v1

Learning evolutionary parameters from genealogies using allelic trees To better understand how genetic differences arise in populations of cells, Aragon et al. created a new method, which estimates how fast cells divide, die,

Our paper is out! Learning evolutionary parameters from genealogies using allelic trees url: academic.oup.com/genetics/art...
With Aleksandra Walczak and @thierrymora.bsky.social
Congrats to first author Antoine Aragon, well done Antoine!

Our new paper is out in PNAS!
We analyzed 125 high-coverage whole genomes from five Sudanese ethnolinguistic groups, to understand the evolutionary and demographic history of the region.
www.pnas.org/doi/10.1073/...
🧵👇

The group I work in at Michigan (along with other two UK unis) will jointly host total four postdocs. All three will have different but related research focuses and we will work on developing ARG driven/inspired quantitative genetics at Michigan.
Formal job posting to follow (1/2).

📢 We're hiring a postdoc (33 months) in human evolutionary genomics / paleogenomics / statistical genetics, Paris 🇫🇷
Project on selection on disease-associated variants, integrating ancient genomes, GWAS, and Ancestral Rec. Graphs.
Start May 2026 (flexible).
Apply here: emploi.cnrs.fr/Offres/CDD/U...

demografr: A toolkit for simulation-based inference in population genetics https://www.biorxiv.org/content/10.64898/2025.12.18.694482v1

Congratulations! 🙌

Thanks for letting me be part of such an interesting topic!

Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats - Nature Communications The intestinal microbiome is shaped by genetics and environment. Here, the authors show in rats that host genetic effects, including indirect social effects, influence microbiome composition, identify...

Our lab’s first paper on host-microbiome interactions is out today!

www.nature.com/articles/s41...

New prehistoric occupations identified in the eastern Iberian Plateau | Antiquity | Cambridge Core New prehistoric occupations identified in the eastern Iberian Plateau

Hallazgos en distintas localizaciones del interior de la Meseta central ibérica refuerzan la hipótesis de una a ocupación humana del Pleistoceno final más frecuente de lo que se suponía:
New prehistoric occupations identified in the eastern Iberian Plateau

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ...

Our latest preprint revisits the classic model of mutation-selection balance.

Do human recessive genes fit Haldane's 100-year old model?

This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io

www.biorxiv.org/content/10.6...

Five important financial moves for PhD students Students and a financial planner give their advice on budgeting, saving and investing during doctoral studies.

I think they missed something. April's Fools day has passed and Spanish Innocent day is on two weeks.

www.nature.com/articles/d41...

Why do tree-based models still outperform deep learning on tabular data? While deep learning has enabled tremendous progress on text and image datasets, its superiority on tabular data is not clear. We contribute extensive benchmarks of standard and novel deep learning...

10/ Bonus reading:
Why do tree-based models still outperform deep learning on tabular data?
arxiv.org/abs/2207.08815