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Alice Pyne

@alicepyne

UKRIFLF & professor of biophysics at the University of Sheffield. High-resolution #AFM and #biophysics studies of #DNA structure and function www.pyne-lab.uk πŸ”¬πŸ§¬ she/her

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09.10.2023
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Latest posts by Alice Pyne @alicepyne

2nd Flyer includes names & titles of the SMBio26 Sheffield selected speakers

2nd Flyer includes names & titles of the SMBio26 Sheffield selected speakers

Organized with the @sheffielduni.bsky.social team: Matt Newton, @alicepyne.bsky.social & Ruby Peters.

πŸ‘ Speakers include Gijs Wuite, @jwelburn.bsky.social, @slfort.bsky.social, @akellett.bsky.social, @michellepeckham.bsky.social & Aakash Basu.

Program & registration --> bit.ly/3NtxZlM

14.01.2026 15:55 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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πŸ“On #WorldMetrologyDay, we celebrate 150 years of measurement science! At #SPM40, precision at the nanoscale is our mission, advancing biomedical research through AI-powered microscopy. #MetrologyMatters #MSCA #ResearchEU

20.05.2025 14:13 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Abstract deadlines coming up soon!
Talk - 14th March
Poster - 28th March

Sign up on our Eventbrite: www.eventbrite.co.uk/e/glasgow-im... and come along and see our wonderful keynote speaker @alicepyne.bsky.social !

For more info, head to the GIN website : glasgowimagingnetwork.wordpress.com

06.03.2025 11:40 πŸ‘ 5 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
Micrograph of keratin networks (green) and DNA (blue) within cells
Image by Rachel Lawson

Micrograph of keratin networks (green) and DNA (blue) within cells Image by Rachel Lawson

🚨 PhD position available for Oct 25

πŸ”¬Using advanced microscopy to understand how keratin networks control tissue mechanics

An interdisciplinary #cellbiology #biophysics collaboration with Ruby Peters & @alicepyne.bsky.social

πŸ‘‡ Apply by March 14

www.findaphd.com/phds/project...

24.02.2025 15:28 πŸ‘ 13 πŸ” 11 πŸ’¬ 1 πŸ“Œ 1
The Peak District from Stansted edge at sunset with a whippet looking out

The Peak District from Stansted edge at sunset with a whippet looking out

It’s been a busy start to the year with marking, paper and grant reviews and travel to SMB2025 in the US, I think we were delayed for as long as we were actually at the conference…

Its good to be home in the Peak District with my best girl Tasso πŸŒ… πŸ• ❀️

17.01.2025 19:03 πŸ‘ 19 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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EDUCATION CORNER: Molecule of the Month: CelebratingΒ  25 Years of Storytelling and Announcing New Beginnings After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month series.Β  Janet Iwasa will be continuing the series for PDB-101.

After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service.
@jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases
Details: cdn.rcsb.org/rcsb-pd...

06.01.2025 17:12 πŸ‘ 137 πŸ” 43 πŸ’¬ 2 πŸ“Œ 9
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Delighted to share our @NAR_Open paper on a click chemistry-derived DNA damaging agent πŸ§¬βœ‚οΈπŸ‘ Congrats to @westerlundlab.bsky.social @alicepyne.bsky.social @researchireland.bsky.social @dcuresearch.bsky.social @sspc.bsky.social @dublincityuni.bsky.social doi.org/10.1093/nar/...

07.01.2025 12:59 πŸ‘ 11 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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Two more weeks to apply to our opening for a senior postdoc in biophysics; work on exciting projects in DNA replication and/or chromatin organization from an interest in instrumentation! Deadline Jan 15 and application link: my.corehr.com/pls/uoxrecru...

02.01.2025 17:46 πŸ‘ 14 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1

I know - there’s a huge tree uprooted just after the stepping stones too - hope you’re having a lovely winter in the Southern Hemisphere!

30.12.2024 11:20 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
A path with failed broken trees by the side

A path with failed broken trees by the side

Today a Tasso jog through Endcliffe park - lots of storm damage with trees uprooted πŸ•

30.12.2024 10:50 πŸ‘ 5 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
A man and a dog in a frost field with the sun just above a hill

A man and a dog in a frost field with the sun just above a hill

Frosty twixmas adventures with Tasso πŸ€πŸ’š

29.12.2024 16:59 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A cloud inversion in the valley of the Peak District

A cloud inversion in the valley of the Peak District

A cloud inversion behind some fields in the Peak District

A cloud inversion behind some fields in the Peak District

A few days of beautiful cloud inversions in the peak. Today a little exploration by bike 🚲- trying to stay above the cloud

28.12.2024 19:04 πŸ‘ 16 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Whippet Tasso in a green field under a bright blue sky

Whippet Tasso in a green field under a bright blue sky

Boxing Day walks with Tasso, enjoying the #PeakDistrict and thinking how much my mum would have loved to have been with us πŸ’š

27.12.2024 07:55 πŸ‘ 21 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
View of the Peak District with the sun breaking through the clouds

View of the Peak District with the sun breaking through the clouds

First Christmas without maman, thinking of her lots and spending time enjoying the Peak District. She loved it up here πŸ’š

25.12.2024 18:35 πŸ‘ 21 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Sunrise in the woods through the trees

Sunrise in the woods through the trees

Celebrating the start of longer days with a beautiful sunrise on a morning trot with Tasso πŸ•

23.12.2024 12:07 πŸ‘ 9 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Only two days left to apply for this amazing opportunity to join SiΓ’n’s lab at Kings. Interested in data analysis, microscopy and working with an awesome PI? One not to miss πŸ”¬ πŸ’»

16.12.2024 17:00 πŸ‘ 9 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield on FindAPhD.com PhD Project - Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield, listed on FindAPhD.com

We have a #PhD available! I'm really excited about this project, looking at whether and how differences in the #IDRs of paralogous epigenetic enzymes CBP and p300 cause them to behave differently. www.findaphd.com/phds/project...

05.12.2024 07:24 πŸ‘ 21 πŸ” 26 πŸ’¬ 1 πŸ“Œ 1
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πŸ“£ Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

16.12.2024 11:50 πŸ‘ 110 πŸ” 117 πŸ’¬ 4 πŸ“Œ 7
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The role of keratin networks in maintaining epithelial tissue integrity at University of Sheffield on FindAPhD.com PhD Project - The role of keratin networks in maintaining epithelial tissue integrity at University of Sheffield, listed on FindAPhD.com

Looking for a #biophysics PhD? There's still time to apply for our Yorkshire Biosciences project on how keratin networks affect the mechanical properties of cells & tissues. Interdisciplinary collab with Ruby Peters & @alicepyne.bsky.social.

Deadline 6th Jan

www.findaphd.com/phds/project...

16.12.2024 13:51 πŸ‘ 3 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1

On my way to London for the @royalmicrosoc.bsky.social Data Analysis in Microscopy section meeting. Excited to catch up in person with everyone and chat all things πŸ”¬ πŸ’»

16.12.2024 12:32 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Gosh it’s beautiful isn’t it! See you there!

15.12.2024 06:03 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A butterfly shaped croissant

A butterfly shaped croissant

A weekend of catching up with old pals from UCL in Hamburg. Tackling the grey drizzle with epic pastries πŸ₯

08.12.2024 15:27 πŸ‘ 12 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We were so happy to have @raveentank.bsky.social join us for our first Insigneo Imaging Life workshop in Sheffield this week. It was an amazing day of microscopyπŸ”¬ and science πŸ§ͺ - thank you Raveen for braving the Manchester-Sheffield train line!

05.12.2024 13:07 πŸ‘ 6 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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MRC DiMeN Doctoral Training Partnership: Understanding the membrane recruitment of oncogenic KRAS in pancreatic cancer at University of Sheffield on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding the membrane recruitment of oncogenic KRAS in pancreatic cancer at University of Sheffield, listed on FindAPhD.com

1/ Cancer cell biology MRC DiMeN project in collaboration with @maiblab.bsky.social & Liz Smythe to use recombinant biosensors to image active KRAS in #pancreaticcancer

Apply by 13th Dec

www.findaphd.com/phds/project...

26.11.2024 15:01 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Multiscale topological analysis of kinetoplast DNA via high-resolution AFM Kinetoplast DNA is a complex nanoscale network, naturally assembled from thousands of interconnected DNA circles within the mitochondrion of certain parasites. Despite the relevance of this molecule t...

In this paper #AFM is used to image the chain-mail structure of kinetoplast #DNA from parasites and automated analysis unravels the complex molecular topology. πŸ§ͺ πŸ”¬ 🧬
@alicepyne.bsky.social doi.org/10.1039/D4CP...

22.11.2024 16:19 πŸ‘ 9 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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Special Issue: Data Analysis in Imaging: Journal of Microscopy: Vol 296, No 3 The <em>Journal of Microscopy</em> is the oldest journal dedicated to the science of microscopy, publishing the latest advances in microscopy techniques and novel areas of application.

The @royalmicrosoc.bsky.social #DataAnalysisInImaging special issue of Journal of Microscopy is out now! onlinelibrary.wiley.com/toc/13652818...

#ImageAnalysis #BioImageAnalysis #RMSDAIM

21.11.2024 15:57 πŸ‘ 36 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0

Come join us in Harrogate for a really exciting programme at the interface of the physical and life sciences! Abstract submission is now open, Harrogate is beautiful and the meeting will be really reasonably priced thanks to all our amazing sponsors πŸ₯³

20.11.2024 19:54 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

I haven't seen a nucleic acids starter pack yet, so I started one! Please reach out if I missed you! go.bsky.app/NxKgUY5

18.11.2024 15:53 πŸ‘ 40 πŸ” 13 πŸ’¬ 15 πŸ“Œ 0
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"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements.
www.biorxiv.org/content/10.1...

19.11.2024 23:40 πŸ‘ 200 πŸ” 59 πŸ’¬ 3 πŸ“Œ 2
SuperPlotsOfData - Plots Data and its ReplicatesAbout

We have tutorials on how to generate SuperPlots in Prism, R, Python, and Excel in the paper, but you can also easily make SuperPlots using @joachimgoedhart.bsky.social's SuperPlotsOfData: huygens.science.uva.nl/SuperPlotsOf...

18.11.2024 19:02 πŸ‘ 41 πŸ” 9 πŸ’¬ 7 πŸ“Œ 0