Riley Hannan

I like biotium's CoverGrip, a limonene-solvated sealant. It is reasonably inexpensive. Otherwise second the silicone sealant or dental cement recs.

Tweet screengrab from Ben Rosen:" REPUBLICANS: We're having the military thrown protesters in unmarked vans DEMOCRATS: mark the vans (with hand clap emoji between words)

That is surprising to me! Need to get the chemists and the finite element / agent based modelers in the same room :)

This is *so cool*, thank you for sharing! That probe is incredible 🤩. Have there been efforts to model local diffusion which consider the complex millieu of the cell? Or has it always been some generalized/averaged diffusion model which assumes homogeneity.

Try Counterpart (2017) - very prescient imagination of a post-plague west. And JK Simmons is incredible.

These read like the script for the next Dracula Flow

Bonus points if you can fake some bloodstains around the core :)

A user didn't clean up after themselves + left behind broken cover slips. You'll never regain full function of those fingers.

LLMs will never be able to perform the modal reasoning required to evaluate science. Only regurgitate some nice sounding soup. As a tool in a human's toolbox, maybe okay. But we know AI would ultimately replace human review in service of profit. Better to not open that door at all.

Wow, why would you post this at me rn

When you think about it, plants are the kulaks of the natural world. Their "photosynthesis" is nothing more than bourgeois parasitism on the honest proletarian labour of the noble Stakhanovite sun

I'd say that qualifies you as being top 0.1% for data management! Any implementation of standards can't additionally burden. Happily there are extant cryptographic signing methods which would work to prove provenance/integrity of files. Adoption is a whole other ballgame + requires difficult buy-in.

Requiring raw data to be digitally signed and submitted with a manuscript, at minimum to pass an automated audit, would help prevent some fraud. Of course you can't ultimately stop people from lying... But raising the barrier of entry for fakery is still beneficial, no?

Whole mount tick imaging! Ooo are you going to try to stain for anything? I bet phalloidin would be beautiful if the tick clears well!

How'd you mount this lil guy?

"Shonky" is entering my vocabulary

Does anyone follow those strict rules? Probably not. Simple scalar multiple test correcting also may be too conservative once your screens get into larger numbers. You need to decide how much you care about Type1 errors and then pick an appropriate correction scheme

In the strictest sense, if your experiment/hypothesis screened 5 drugs and you do anything other than test all (correct for 5x tests), you're breaking the rules. You can see your results and run ANOTHER, NEW experiment on the one or two drugs which were exciting, and have more power bc fewer tests.

Does your question involve testing the dependence of outcome on two factors? Then two-factor ANOVA/nonparametric equivalent. If you have tested two(or more) conditions independently, and are looking for significance in *any* test, you can use your regular statistics, corrected for multiple testing.

It's very weird to feel pride in Jim having read this letter after spending the entirety of his term as President being continuously disappointed. Maybe this is Jim unshackled from his self-imposed decorum.

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
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Good drugs?

I enjoy this because it has given me a dozen new (to me) authors whose opinions I can throw directly into the garbage.

AI’s Invasive Species The slop is winning.

Hi. I wrote an essay about AI slop: How it feels like an invasive species for the internet. How its boosters describe building a future that’s devoid of craft. How frictionlessness can be nihilistic & how this stuff seems to leach part of our shared humanity out of the world. I hope you'll read it.

Sundog/22* halo?

"Terrible things are happening outside. At any time of night and day, poor helpless people are being dragged out of their homes" ... "Children come home from school to find that their parents have disappeared. Women return from shopping to find their houses sealed, their families gone."

Will freely admit to having learned/thought/taught phenol red was the culprit. Mea culpa.

Honestly it's a pretty easy and very engrossing read!

It's a wild read. Big jailtime for people if charges stick

out.reddit.com/t3_1o3dzi9?u...